Oncogenesis - Dual downregulation of HRK and BAD promotes BCL-xL-mediated docetaxel resistance in prostate cancer

The Montero Lab at the University of Barcelona's Department of Biomedical Sciences is dedicated to exploring the biology of cancer metastasis.

The SFPM Seminar series is for those interested in the use of assaying technology to further biomarker discovery, drug R&D and personalized healthcare outcomes.

Un equip internacional codirigit per l'Institut de Bioenginyeria de Catalunya (IBEC) i l'Hospital West China de la Universitat de Sichuan (WCHSU) va poder revertir l'Alzheimer en ratolins després de n...

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Investigadors de l'Hospital del Mar vinculen per primer cop una proteïna a la metàstasi en el càncer de mama i obren la porta a tractaments preventius

The SFPM Seminar series is for those interested in the use of assaying technology to further biomarker discovery, drug R&D and personalized healthcare outcomes.

Acquired therapeutic resistance is a key contributor to cancer treatment failure, requiring new approaches to address its complex mechanisms. In this Roadmap, Soragni, Knudsen and colleagues discuss t...

Cell Death & Disease - Novel selective strategies targeting the BCL-2 family to enhance clinical efficacy in ALK-rearranged non-small cell lung cancer

The Montero Lab at the University of Barcelona's Department of Biomedical Sciences is dedicated to exploring the biology of cancer metastasis.

Caspases TIR signaling activates caspase-like immunity in bacteria – François Rousset, Ilya Osterman, Tali Scherf, Alla H. Falkovich, Azita Leavitt, Gil Amitai, Sapir Shir, Sergey Malitsky, M…

Key PointsBlast-specific ex vivo venetoclax sensitivity correlated strongly with treatment responses and predicted longer survival.VenEx trial showed that

Després de tractar un tumor amb quimioteràpia i radioteràpia, es poden originar unes cèl·lules que es coneixen com a senescents. Són cèl·lules que no es divideixen, estan involucrades en el procés d’envelliment i són resistents a la mort cel·lular, però encara són actives metabòlicament en el cos humà. Quan s’hi acumulen, poden posar en risc la recuperació dels pacients. Ara, una recerca liderada per la UB descriu per primer cop un mecanisme molecular que podria impulsar el disseny d’estratègies per eliminar les cèl·lules senescents en els pacients oncològics.

Cell Death & Differentiation - HRK downregulation and augmented BCL-xL binding to BAK confer apoptotic protection to therapy-induced senescent melanoma cells

The SFPM Seminar series is for those interested in the use of assaying technology to further biomarker discovery, drug R&D and personalized healthcare outcomes.

Researching Cell Death