An RNA-binding protein on leukemia cells provides an effective target in mouse models.

Abstract. Across cell types and organisms, thousands of RNAs display asymmetric subcellular distributions. Studying this process requires quantifying abund

The degree to which translational control is specified by mRNA sequence is poorly understood in mammalian cells. Here, we constructed and leveraged a compendium of 3,819 ribosomal profiling datasets, ...

Hervé, Scelfo et al. show that chromosome mis-segregation induces mTORC2- and ATR-mediated p53 activation through a mechanosensitive checkpoint at the nuclear envelope triggered by altered heterochrom...

Life history ecology provides a framework for understanding the complex interactions between organisms and their environments but is challenging to resolve for long-lived and migratory species. In fis...

MYC induces a previously uncharacterized type of oncogenic stress by increasing global RNA degradation and downstream ribonucleotide catabolism and ROS accumulation; this catabolic vulnerability can b...