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John Murray

@jisaacmurray.bsky.social
511 followers 261 following 12 posts

Associate Professor of Genetics, University of Pennsylvania. Genomics of development, gene regulation, C. elegans.

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Reposted by John Murray
Maureen Barr @barrlab.bsky.social · 14/05/2026
The International C. elegans meeting #worm27 is going to Kobe, Japan in 2027! genetics-gsa.org/celegans/ Organizers: Erik Andersen @erikandersen.bsky.social, Johns Hopkins University Kavita Babu @kavita-babu.bsky.social, IISc Bangalore Suhong Xu, Zhejiang University @genetics-gsa.bsky.social
Genetics Society of America. 26th International Worm Meeting
July 18-22, 2027
Kobe, Japan
Kobe Convention Center
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Colin Conine @colinconine.bsky.social · 05/05/2026
Now published in @natcomms.nature.com
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Mostafa Zamanian @zamanian.bsky.social · 27/03/2026
“CELeidoscope: quad-fluorescent strain for tissue-specific spectral single-cell analyses”. Engineered a C. elegans strain that enables spectral sorting of multiple major cell types within a single strain population. Led by Clair Henthorn and Natalia Betancourt. www.biorxiv.org/content/10.6...
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John Murray @jisaacmurray.bsky.social · 10/03/2026
So much friction!
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John Murray @jisaacmurray.bsky.social · 06/03/2026
Coolest class demo ever. What were the results?
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John Murray @jisaacmurray.bsky.social · 05/03/2026
lol I learned this as “double and add 30” (since of course everyone wants to convert from C to F not other way around!)
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Genetics Society of America @genetics-gsa.bsky.social · 03/03/2026
David Botstein, a titan within the scientific community, died last week. GSA mourns his passing and celebrates his legacy. Read more about his significance to our community in this thread ⬇️🧵
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John Murray @jisaacmurray.bsky.social · 02/03/2026
“But that’s not the weird part!”
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Harmit Singh Malik @harmitmalik.bsky.social · 19/02/2026
Extra “kudos” to those who caved pre-emptively to this now defunct directive
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Meera Sundaram @meera-sundaram.bsky.social · 23/01/2026
share.inquirer.com/qkghqI
share.inquirer.com
The Trump administration tore down 400 years of Black history in Philadelphia. So what happens now?
Philadelphians are grappling with the aftermath of Thursday’s abrupt removal of all exhibits at the President’s House ahead of 250th anniversary celebrations.
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David Katz @katzlab.bsky.social · 07/10/2025
Very excited to share our very exciting story on how misinherited chromatin affects individual cells to cause a behavior defect in C. elegans (a thread👇) www.pnas.org/doi/10.1073/...
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Golnaz Vahedi @vahedilab.bsky.social · 23/09/2025
The Vahedi Lab is seeking a highly motivated Research Specialist A/B to join our dynamic research group studying the mechanisms of immune regulation. Apply here: wd1.myworkdaysite.com/recruiting/u...
wd1.myworkdaysite.com
Research Specialist A/B
University Overview The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school co...
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Meital Oren @meital.bsky.social · 08/08/2025
highlight of two recent fantastic comparative inter-species single-cell atlases, by @live-large.bsky.social from @jisaacmurray.bsky.social, and Itai Toker from Oliver Hobert's lab www.sciencedirect.com/science/arti...
sciencedirect.com
Evolution of nervous systems: Molecular divergence in a conserved body plan
Comparative inter-species single-cell atlases of Caenorhabditis whole embryos and larval nervous systems reveal deep conservation of cell type identit…
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John Murray @jisaacmurray.bsky.social · 02/07/2025
Yay thank you for all of your amazing work and for sharing this fabulous news!
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John Murray @jisaacmurray.bsky.social · 30/06/2025
I think everyone is certain what the number is. Not sure the number they are certain about is the same though…
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Javier Apfeld @javierapfeld.bsky.social · 30/06/2025
Go worms! #worm25
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John Murray @jisaacmurray.bsky.social · 30/06/2025
Worm25 has been absolutely fantastic so far-congrats to everyone for your amazing work! One striking change in the talks this year is it seems like the consensus number of neurons in the adult hermaphrodite has returned to 302 after a few years at 300. Is CAN back?
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John Murray @jisaacmurray.bsky.social · 20/06/2025
@live-large.bsky.social @junhyongkim.bsky.social @rupakhanal.bsky.social
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Maureen Barr @barrlab.bsky.social · 20/06/2025
🤯 @jisaacmurray.bsky.social!!!!
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junhyongkim.bsky.social @junhyongkim.bsky.social · 20/06/2025
Despite all that is going on, we are still all working on our science. Our 2nd collaboration with @jisaacmurray.bsky.social‬ and Bob Waterston (UW) is out: Lineage-resolved analysis of embryonic gene expression evolution in C. elegans and C. briggsae | Science www.science.org/doi/10.1126/...
science.org
Lineage-resolved analysis of embryonic gene expression evolution in C. elegans and C. briggsae
The constraints that govern the evolution of gene expression patterns across development remain unclear. Single-cell RNA sequencing can detail these constraints by systematically profiling homologous ...
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Meera Sundaram @meera-sundaram.bsky.social · 20/06/2025
Different species, same cell lineage, some gene expression patterns changed, others not so much…lots to dig into here! From @jisaacmurray.bsky.social lab
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John Murray @jisaacmurray.bsky.social · 20/06/2025
I won’t summary all the results here but interesting variation across cell types in the degree of conservation, examples of heterochronic evolution, and insight into the expression fate of duplicated genes.
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John Murray @jisaacmurray.bsky.social · 20/06/2025
These two species have nearly identical lineages despite having genome sequences nearly as different as human and chicken. This allowed us to explore by single cell RNA-seq how progenitor and terminal cell types vary in the same cell across this long evolutionary distance.
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John Murray @jisaacmurray.bsky.social · 20/06/2025
Happy to announce our paper comparing embryonic gene expression between C. elegans and C. briggsae, work led by Christopher Large with Rupa Khanal and in collaboration with Junhyong Kim and Bob Waterston. www.science.org/doi/10.1126/...
science.org
Lineage-resolved analysis of embryonic gene expression evolution in C. elegans and C. briggsae
The constraints that govern the evolution of gene expression patterns across development remain unclear. Single-cell RNA sequencing can detail these constraints by systematically profiling homologous ...
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Reposted by John Murray
Erich M. Schwarz @erichmschwarz.bsky.social · 06/12/2024
After 5 years, our team has a new telomere-to-telomere gap-free reference genome for C. elegans. We published our first results in 2019; I thought we'd have our loose ends wrapped up by spring 2020. That prediction was ... slightly off. But here's the genome now! www.biorxiv.org/content/10.1...
biorxiv.org
CGC1, a new reference genome for Caenorhabditis elegans
The original 100.3 Mb reference genome for Caenorhabditis elegans , generated from the wild-type laboratory strain N2, has been crucial for analysis of C. elegans since 1998 and has been considered co...
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Coleen Murphy @ctmurphy1.bsky.social · 05/12/2024
My first Bluesky paper post! I’m pleased to announce the publication of our single-nucleus atlas of adult neurons from wild-type and long-lived, better performing insulin receptor (daf-2) mutants, by Jon St. Ange and Yifei Weng et al.DOI: 10.1016/j.xgen.2024.100720
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Michael P Hart 🏳️‍🌈 (he/him) @michaelphart1.bsky.social · 11/11/2024
New paper ALERT!! Mara Cowen, PhD discovered and defined how conserved autism-associated genes modify a 'social' behavior in C. elegans!! So proud of her work in the lab! www.nature.com/articles/s41...
nature.com
Conserved autism-associated genes tune social feeding behavior in C. elegans - Nature Communications
C. elegans aggregate in large clumps during feeding. Here, the authors find conserved autism-associated genes mediate distinct molecular and circuit signaling components that tune C. elegans feed...
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Patrick Phillips @patrickphillips.bsky.social · 22/11/2024
A reminder for new folks. BlueSky does not have an algorithm to raise posts of interest. It is incumbent upon you to do so via reposting. Liking things only provides feedback to the poster but does not promote the post. The signal to noise ratio is taking a brief beating, so great to help curate.
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John Murray @jisaacmurray.bsky.social · 20/11/2024
👋
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