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James Greenan-Barrett

@jgreenanbarrett.bsky.social
976 followers 402 following 38 posts

NIHR Academic Clinical Fellow in Infectious Diseases | Specialist Registrar in Infectious Diseases & General Internal Medicine | UCL Respiratory & LSHTM | Interested in TB biomarkers, disease states & natural history

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Reposted by James Greenan-Barrett
James Greenan-Barrett @jgreenanbarrett.bsky.social · 14/10/2025
Check out our new paper in @lancetmicrobe.bsky.social In this IPD-MA we show that single-gene transcripts are equivalent to multi-gene signatures to Dx subclinical TB They perform consistently across settings + show potential clinical utility to stratify therapy #IDsky #TBsky bit.ly/47jU7GN
bit.ly
Single-gene transcripts for subclinical tuberculosis: an individual participant data meta-analysis
Single-gene transcripts are equivalent to multi-gene signatures for detection of subclinical tuberculosis, with consistent performance across settings. Single-gene transcripts show potential clinical ...
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James Greenan-Barrett @jgreenanbarrett.bsky.social · 14/10/2025
Check out our new paper in @lancetmicrobe.bsky.social In this IPD-MA we show that single-gene transcripts are equivalent to multi-gene signatures to Dx subclinical TB They perform consistently across settings + show potential clinical utility to stratify therapy #IDsky #TBsky bit.ly/47jU7GN
bit.ly
Single-gene transcripts for subclinical tuberculosis: an individual participant data meta-analysis
Single-gene transcripts are equivalent to multi-gene signatures for detection of subclinical tuberculosis, with consistent performance across settings. Single-gene transcripts show potential clinical ...
125
Reposted by James Greenan-Barrett
Daniel Grint @danieljgrint.bsky.social · 13/06/2025
Optimising the use of currently available treatments through treatment stratification could reduce treatment duration by 2-months for the majority. TB treatment stratification strategies should be prospectively trialled in a phase III RCT. #TBSky
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Reposted by James Greenan-Barrett
Mahdad Noursadeghi @mnoursad.bsky.social · 27/03/2025
We’re hiring! Looking for a laboratory post-doc fellow to help us disentangle protective and pathogenic T cells in TB, so we can stratify disease-risk after infection, and develop more effective vaccines. Interdisciplinary science in the heart of London. What's not to like? More here: bit.ly/4iIEiwu
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Reposted by James Greenan-Barrett
Hannah Rickman @hannahrickman.bsky.social · 10/01/2025
New preprint (with all pre-print caveats!) tinyurl.com/589ffhu4 on Mtb infection risk by sex & age. Men are at higher risk of #tuberculosis v women- but unclear how much driven by higher infection vs progression to disease. We meta-analysed Mtb immunoreactivity surveys to find out more🧵 #tbsky
papers.ssrn.com
Sex Differences in the Risk of Mycobacterium Tuberculosis Infection: A Systematic Review and Meta-Analysis of Population-Based Immunoreactivity Surveys
Background: Tuberculosis (TB) killed 1·25 million people globally in 2023. Men have a 1·7-fold higher TB incidence than women, but it is not known to what exten
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James Greenan-Barrett @jgreenanbarrett.bsky.social · 05/01/2025
“…despite the recent introduction of BPaL/M, resistance to these new antituberculosis drugs has already developed in at least 27 countries across four continents. Furthermore, a quarter of these cases involved patient-to-patient transmission” Worrying stuff
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Reposted by James Greenan-Barrett
Tom Scriba @tomscriba.bsky.social · 13/12/2024
Interested in the immunopathology of human tuberculosis? Here is our latest review: www.science.org/doi/10.1126/...
science.org
Immunopathology in human tuberculosis
The balance between protective and pathological immune responses shapes progression of Mycobacterium tuberculosis infection.
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Reposted by James Greenan-Barrett
Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · 21/11/2024
🆕️⚡️⚡️Selected TB blood RNA signatures& CRP do not provide biomarkers of microbiological clearance to support TB treatment cessation at 8 weeks CRP achieved marginal albeit statistically significant discrimination/AUROC 0.69(95%CI 0.52–0.87) #idsky #medsky #tbsky publications.ersnet.org/content/erj/...
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Reposted by James Greenan-Barrett
Mahdad Noursadeghi @mnoursad.bsky.social · 30/11/2024
First wave ISGs (eg MX1) induced rapidly, correlate with VL & infectivity - potential biomarker to stratify patients who'll benefit from antivirals?
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James Greenan-Barrett @jgreenanbarrett.bsky.social · 01/12/2024
Check out our paper on RNA biomarkers in COVID-19 MX1 expression occurred early in infection before PCR detection…potential role to stratify treatment #IDSky
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James Greenan-Barrett @jgreenanbarrett.bsky.social · 19/11/2024
Historical evidence that mass CXR screening is feasible and effective Very cool study - lots to be learnt from the past… #TBSky
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James Greenan-Barrett @jgreenanbarrett.bsky.social · 18/11/2024
#UnionConf2024 has wrapped up, and what a conference! Some fascinating talks and great discussions. Seems to me that there are more questions than answers right now in #TBSky but its an exciting time.. Some personal highlights (in no particular order): 1/10
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