iiinova — where your digital self keeps evolving

Jet M.J. Vonk, PhD PhD @jetmjvonk.bsky.social · 29/09/2026

Our new paper in @braincomms.bsky.social shows that AI-based analysis of speech errors in brief reading task distinguish nonfluent vs logopenic PPA. Automated errors align with expert ratings, showing potential as practical scalable tool to aid differential diagnosis academic.oup.com/braincomms/a...

010

Jet M.J. Vonk, PhD PhD @jetmjvonk.bsky.social · 25/08/2026

Our new paper in Memory & Language, led by Dr. Phillip Hamrick, shows that better episodic memory links to greater lexical diversity in spontaneous speech across English/Spanish + adulthood, suggesting memory shapes how we use our vocabulary throughout life www.jbe-platform.com/content/jour...

000

Reposted by Jet M.J. Vonk, PhD PhD

UCSF Edward and Pearl Fein Memory and Aging Center @ucsfmac.bsky.social · 04/08/2026

Could a brief speech sample support primary progressive aphasia (PPA) diagnosis? Researchers at the UCSF Fein Memory and Aging Center found that automated analysis of a 1-2 minute picture description accurately distinguished PPA variants and aligned with known brain and pathology patterns.

Three side-by-side images of the left side of the brain show areas where speech patterns are associated with different forms of primary progressive aphasia (PPA). Colored regions (blue to red, with warmer colors indicating stronger associations) highlight different brain areas for each subtype. Nonfluent PPA is associated mainly with the left frontal regions involved in speech production. Logopenic PPA is associated with the left posterior temporal and parietal regions involved in language processing. Semantic PPA is associated with the anterior temporal lobes, especially on the left, which support word and concept knowledge. These images illustrate that each PPA subtype is linked to a distinct pattern of brain changes.

021

Reposted by Jet M.J. Vonk, PhD PhD

JAMA Neurology @jamaneurology.com · 03/08/2026

In #PrimaryProgressiveAphasia, automated #SpeechAnalysis of a brief picture description task distinguished nonfluent, logopenic, and semantic variants and produced interpretable speech profiles. ja.ma/4w4A2xg

Figure 1: Multinomial Speech Profiles for Primary Progressive Aphasia Variants. A 3D scatterplot shows nfvPPA (orange), lvPPA (dark teal), and svPPA (light teal) data points forming distinct clusters. Three confusion matrices display classification accuracy for clinical diagnoses and underlying neuropathologies.

011

Jet M.J. Vonk, PhD PhD @jetmjvonk.bsky.social · 03/08/2026

Our new paper in @jamaneurology.com shows that automated analysis of just 1–2 minutes of speech can accurately distinguish primary progressive aphasia variants and reflects their underlying anatomy & pathology, with potential as a practical, interpretable tool to aid diagnosis and disease monitoring

031

Jet M.J. Vonk, PhD PhD @jetmjvonk.bsky.social · 13/05/2026

Our new paper in Alzheimer’s & Dementia, led by Dr. Grebe, shows that higher education/occupation (cognitive reserve proxies) first support better semantic function in svPPA despite more brain atrophy, but then faster decline as reserve depletes: alz-journals.onlinelibrary.wiley.com/doi/epdf/10....

020

Jet M.J. Vonk, PhD PhD @jetmjvonk.bsky.social · 01/05/2026

Our new paper in Cerebral Circulation – Cognition and Behaviour, led by Sanne Kuipers & Malin Overmars, applies Natural Language Processing to >1k memory clinic letters to study sex differences in documented cognitive features. Read here: www.sciencedirect.com/science/arti...

020

Jet M.J. Vonk, PhD PhD @jetmjvonk.bsky.social · 12/02/2026

On behalf of the @istaart.bsky.social Design and Data Analytics PIA: New paper in Experimental Gerontology extends principal stratification to estimate the Survivor Average Causal Effect to model heterogeneity in treatment response in gerontologic trials. doi.org/10.1016/j.ex...

doi.org

Redirecting

100

Reposted by Jet M.J. Vonk, PhD PhD

UCSF Edward and Pearl Fein Memory and Aging Center @ucsfmac.bsky.social · 12/02/2026

Causal Inference with Imperfect Data: Trial Emulation and Transportability Methods to Inform Dementia Prevention and Treatment Elizabeth Rose Mayeda, PhD UCLA UCSF Fein Memory and Aging Center Grand Rounds Monday, March 2, 10–11 a.m. PT register 👉

bit.ly

Edward and Pearl Fein Memory and Aging Center Grand Rounds

Causal Inference with Imperfect Data: Trial Emulation and Transportability Methods to Inform Dementia Prevention and Treatment Elizabeth Rose Mayeda, PhD Associate Professor of Epidemiology UCLA…

022

Jet M.J. Vonk, PhD PhD @jetmjvonk.bsky.social · 05/02/2026

On behalf of @istaart.bsky.social #DaDA PIA: Join in San José at AAIC Neuroscience Next! 🧠 Feb 26, 2026 — Aging Research: Intro to Longitudinal Data Analysis Hands-on workshop with Dr. Ana W. Capuano on modeling change in cognition & function over time using real data. Registration now open!

011

Jet M.J. Vonk, PhD PhD @jetmjvonk.bsky.social · 20/01/2026

Our new paper in Alzheimer’s & Dementia shows that automated item-level fluency features improve classification of semantic vs logopenic PPA. They outperform total scores & align with brain atrophy patterns—supporting scalable disease monitoring. alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

040

Jet M.J. Vonk, PhD PhD @jetmjvonk.bsky.social · 15/01/2026

On behalf of @istaart.bsky.social #DaDA PIA: Postdoctoral Associate opening in Pragmatic Dyadic Design. Seeking candidates with a PhD in biostatistics/quantitative methods, strong programming skills, and interest in pragmatic trials and AD/ADRD care. Apply here: postdocs.yale.edu/posts/2025-1...

010

Jet M.J. Vonk, PhD PhD @jetmjvonk.bsky.social · 08/01/2026

On behalf of @istaart.bsky.social Design and Data Analytics #DaDA PIA: Are you interested in open science in #dementia research? Take the WYLDementia survey on data sharing in dementia research! Only 10 minutes, your insights can help shape more open & equitable science. forms.gle/GVuWAeHGmjaq...

forms.gle

Data Sharing Practices Survey

Thank you for taking the time to participate in this survey. The purpose of this survey, led by World Young Leaders of Dementia (WYLD Network) is to better understand data-sharing practices, percept...

010

Jet M.J. Vonk, PhD PhD @jetmjvonk.bsky.social · 08/01/2026

Excited to share the launch of our new @istaart.bsky.social Cognition PIA SIG: Speech and Language Measures in Alzheimer’s Disease and Related Disorders, co-chaired with Alexandra König. Join our 1st meeting Jan 22, 2026 12:35pm CT (open to ISTAART members) Register: forms.monday.com/forms/9fd36c...

021

Jet M.J. Vonk, PhD PhD @jetmjvonk.bsky.social · 07/01/2026

Don’t miss our free @istaart.bsky.social #DaDA PIA Year in Review webinar on Measurement Invariance & Harmonization across Cohorts, Jan 13 11:30am CT! Hear from speaker Dr. Sneha Mani & panelists Drs. Natalia Gomes Goncalves & Lars Lau Raket, moderated by yours truly. Register: alz.org/YearInReview

alz.org

Year in Review [Educational Series] - Category Home - ISTAART Community

PIA Year in Review - 88

000

Jet M.J. Vonk, PhD PhD @jetmjvonk.bsky.social · 16/12/2025

On behalf of @istaart.bsky.social Design and Data Analytics #DaDA PIA: New paper by Newsom et al. in Journal of Aging and Health explores how social support and strain predict multimorbidity trajectories. Support was linked to lower morbidity accumulation: journals.sagepub.com/doi/full/10....

000

Jet M.J. Vonk, PhD PhD @jetmjvonk.bsky.social · 12/12/2025

On behalf of the @istaart.bsky.social Design and Data Analytics #DaDA PIA: 📣 An exciting full-time opportunity as a Postdoctoral Associate in Gerontologic Biostatistics at the Yale School of Medicine. Apply here: postdocs.yale.edu/posts/2025-1...

postdocs.yale.edu

Postdoctoral Associate Position in Pragmatic Dyadic Design

000

Jet M.J. Vonk, PhD PhD @jetmjvonk.bsky.social · 25/11/2025

On behalf of @istaart.bsky.social Design and Data Analytics PIA: We’ve compiled a new Resource Page on the ISTAART website highlighting key websites and tools shared during our #DaDA PIA Day at #AAIC2025. Check it out (PIA members only): urldefense.com/v3/__https:/... (File Categories>Resources)

urldefense.com

Single Sign On

010

Jet M.J. Vonk, PhD PhD @jetmjvonk.bsky.social · 19/11/2025

On behalf of @istaart.bsky.social Design and Data Analytics PIA: New paper by Davis-Plourde et al. in Statistics in Medicine presenting 3 mixed model approaches for incorporating baseline outcomes in stepped wedge CRTs—valuable for trial design methodology. onlinelibrary.wiley.com/doi/10.1002/...

onlinelibrary.wiley.com

Designing Stepped Wedge Cluster Randomized Trials With a Baseline Measurement of the Outcome

Stepped wedge cluster randomized trials (SW-CRTs) are a type of uni-directional crossover designs and are increasingly common in prevention and implementation research. Although sample size formulas ...

000

Jet M.J. Vonk, PhD PhD @jetmjvonk.bsky.social · 17/11/2025

📣 Help shape our @istaart.bsky.social DaDA 2026 Year in Review webinar w/Dr. Sneha Mani on Measurement Invariance and Harmonization across Cohorts! What were standout papers, methods, or insights in 2025? What’s next in 2026? 📚 Suggest papers+trends: alz.surveymonkey.com/r/FSG8RXX ⏳ Deadline: Dec5

bit.ly

020

Jet M.J. Vonk, PhD PhD @jetmjvonk.bsky.social · 14/11/2025

On behalf of the @istaart.bsky.social Design and Data Analytics #DaDA PIA: New work by Dr. Lars Lau Raket et al. in Brain maps time course of #Alzheimer’s disease biomarkers—showing journey from #amyloid β positivity to severe #dementia spans up to 25 years. Open access: doi.org/10.1093/brai...

doi.org

Estimating the time course of biomarker changes in Alzheimer’s disease

Raket et al. study the time course of biomarker changes in Alzheimer's disease, from the earliest detectable changes—often appearing a decade prior to symp

010

Jet M.J. Vonk, PhD PhD @jetmjvonk.bsky.social · 27/10/2025

On behalf of the @istaart.bsky.social Design and Data Analytics PIA: Join for Webinar 3 in the ARISE 2025 series on Wed Oct 29, 12–1 PM CT! 🎓 Featuring early-career researchers at the intersection of aging, statistics, and data science Free and open to all – no registration required

000

Jet M.J. Vonk, PhD PhD @jetmjvonk.bsky.social · 02/10/2025

Proud to share that I’ve received the official Notice of Award for my R01 from NIH National Institute on Aging: a 5yr $4.6M project to develop and validate speech-based tools for early Alzheimer’s detection. Grateful for my collaborators and the support—and spread the word: I’m hiring a postdoc!

160

Jet M.J. Vonk, PhD PhD @jetmjvonk.bsky.social · 02/09/2025

Our new paper in Movement Disorders, led by Franco Ferrante, shows that digital fluency metrics from can predict and classify cognitive phenotypes in Parkinson’s disease, enabling scalable neuropsychological screenings. Read here: movementdisorders.onlinelibrary.wiley.com/doi/full/10....

020

Jet M.J. Vonk, PhD PhD @jetmjvonk.bsky.social · 02/09/2025

On behalf of the @istaart.bsky.social Design and Data Analytics PIA: We’re proud of our achievements and vibrant membership over the past year—and excited to keep building momentum in the year ahead!

131

Jet M.J. Vonk, PhD PhD @jetmjvonk.bsky.social · 26/08/2025

On behalf of the @istaart.bsky.social Team: Join this week for one of two ISTAART All-Member Town Halls! 🌍 Learn about PIAs, meet leadership, and explore ways to get involved. 📅 Aug 26, 5–6 PM CDT 📅 Aug 27, 9–10 AM CDT 🔗 istaart.alz.org/home #ISTAART #AAIC

istaart.alz.org

Home - ISTAART Community

031

Jet M.J. Vonk, PhD PhD @jetmjvonk.bsky.social · 19/08/2025

On behalf of the @istaart.bsky.social Design and Data Analytics PIA: 🚨 Aug 27 = ARISE 2025 launch! 🚨 Join for cutting-edge work by early-career scientists in aging + data science—no registration needed. 🧠 Genetics, changepoints, missingness in EHRs. 📍 Free & open to all! #ARISE #AgingResearch

130

Jet M.J. Vonk, PhD PhD @jetmjvonk.bsky.social · 30/07/2025

Our @istaart.bsky.social Design and Data Analytics #DaDA PIA committee and friends got together on Monday night at Toronto Island and had a blast! #AAIC25

090

Jet M.J. Vonk, PhD PhD @jetmjvonk.bsky.social · 28/07/2025

Tomorrow (Tue) morning at #AAIC25: join us for a fantastic session on Speech and Language Methods for Detecting and Tracking Cognitive Decline 🧠🗣️ 📍 Room 107, North Building (Level 100) 🕘 9:00–10:30 AM 📅 Tuesday, July 29 🚶‍♀️ 8 min from Exhibit Hall Don’t miss it!

060

Jet M.J. Vonk, PhD PhD @jetmjvonk.bsky.social · 26/07/2025

Happening now! #DaDA PIA session on design and analysis of non-pharmacological interventions in room Harbor C at #AAIC25 ; it's not too late to sneak in and take a seat!

081

Jet M.J. Vonk, PhD PhD @jetmjvonk.bsky.social · 26/07/2025

Good morning Toronto! Ready for #AAIC25? It's Professional Interest Area #PIA day today at the Westin Harbour Castle, visit the Design and Data Analytics #DaDA booth for networking (12.30-2.30pm) and our session on design and analysis in trials at Harbour C (3.45-4.45pm)! See you there?

030

Jet M.J. Vonk, PhD PhD @jetmjvonk.bsky.social · 16/07/2025

Our new paper in Epidemiology examines how timescale choice—study time vs. age—can influence estimates of exposure effects on memory change. Using data from 10 cohorts, we show how timescale decisions may shape findings and offer guidance for future cognitive aging research. doi.org/10.1097/EDE....

020

Reposted by Jet M.J. Vonk, PhD PhD

Davide Bruno @davidebrunophd.bsky.social · 16/06/2025

Happy to see the whole special section on the Journal of Neuropsychology (@bpsofficial.bsky.social) about the biomarker-based diagnosis of Alzheimer's disease (@alzassociation.bsky.social, @dementiaresearcher.bsky.social). Thanks to all authors! (Continued) 🧠 🧪 @jamiereillycog.bsky.social

284

Jet M.J. Vonk, PhD PhD @jetmjvonk.bsky.social · 10/06/2025

On behalf of the @istaart.bsky.social Design and Data Analytics PIA #DaDA: New paper by Sun et al. presents a semiparametric joint model to examine how #biomarkers evolve with age and time to disease onset, applied to preclinical #Alzheimer’s. Read in Biometrics: doi.org/10.1093/biom...

doi.org

Semiparametric joint modeling for biomarker trajectory before disease onset

ABSTRACT. Understanding how biomarkers change in relation to disease pathogenesis is a key area in biomedical research. We propose a semiparametric joint m

010

Jet M.J. Vonk, PhD PhD @jetmjvonk.bsky.social · 04/06/2025

On behalf of the @istaart.bsky.social Design and Data Analytics PIA #DaDA: Don’t miss Dr. Ana Capuano’s @anacapuano.bsky.social seminar “Modeling Change and Understanding Dementia Risk in Aging Research” at the University of Iowa on June 12 2025, 12–1 p.m. CT #Dementia #Aging

010

Jet M.J. Vonk, PhD PhD @jetmjvonk.bsky.social · 22/05/2025

On behalf of the @istaart.bsky.social Design and Data Analytics (#DaDa) Professional Interest Area (#PIA):

000

Jet M.J. Vonk, PhD PhD @jetmjvonk.bsky.social · 14/05/2025

On behalf of the @istaart.bsky.social Design and Data Analytics (#DaDa) Professional Interest Area (#PIA):

010

Jet M.J. Vonk, PhD PhD @jetmjvonk.bsky.social · 13/05/2025

On behalf of @istaart.bsky.social Design and Data Analytics PIA: ARISE is calling for innovative data science methods in aging research! Students & young scientists, submit your work for a chance to present in our inaugural webinar series. Top projects win medals! Apply: forms.gle/EUrtnrFyNiuoj2Mf7

forms.gle

ARISE: Aging Research – Innovations in Statistical Exploration

Welcome to ARISE — a program of the ASA Statistics and Data Science in Aging Interest Group! Are you a promising student developing innovative data science methods with applications in aging research?...

001

Jet M.J. Vonk, PhD PhD @jetmjvonk.bsky.social · 29/04/2025

On behalf of the @istaart.bsky.social Design and Data Analytics PIA: New study estimates how chronic conditions contribute to mortality across racial/ethnic groups. #Dementia showed the strongest link to death across groups. Read more: www.sciencedirect.com/science/arti... #ISTAART

sciencedirect.com

Contribution of Chronic Conditions to Mortality: Differences by Race and Ethnicity

Racial and ethnic health disparities are persistent in the United States. The accumulation of chronic conditions and mortality are important contribut…

022

Reposted by Jet M.J. Vonk, PhD PhD

Davide Bruno @davidebrunophd.bsky.social · 23/04/2025

Happy to share this commentary that @jamiereillycog.bsky.social and I wrote for our special section on the biomarker-based dx of Alzheimer's disease! doi.org/10.1111/jnp.... Featuring @ignaciomastro.bsky.social @smgrasso.bsky.social @jetmjvonk.bsky.social @timdaly.bsky.social

262

Jet M.J. Vonk, PhD PhD @jetmjvonk.bsky.social · 17/04/2025

Our new paper in Neurology shows that automated speech analysis differentiates frontotemporal dementia subtypes using linguistic & acoustic features that align with known neuroanatomical patterns. This tool may aid early diagnosis & trial enrollment for TDP43 proteinopathies doi.org/10.1212/WNL....

0182

Jet M.J. Vonk, PhD PhD @jetmjvonk.bsky.social · 19/03/2025

On behalf of the @istaart.bsky.social Design and Data Analytics PIA #DaDA: New study by Lin et al. finds that at least 1 in 5 people with dementia & functional limitations receive no personal assistance, across several global regions. Read more in Nature Aging: doi.org/10.1038/s43587-025-00836-y

doi.org

Absence of care among community-dwelling older adults with dementia and functional limitations - Nature Aging

Using data from the United States, England, Europe, Israel and China, Lin, Qian et al. identify that at least one-fifth of persons with dementia and functional limitations received no care for daily a...

000

Jet M.J. Vonk, PhD PhD @jetmjvonk.bsky.social · 28/02/2025

On behalf of @istaart.bsky.social Design and Data Analytics PIA: Learn valuable skills on March 24 10am CT when you join us for our webinar on how to carry out a meta-analysis in #dementia research with Mike Malek-Ahmadi, Heather Allore and Jet Vonk 🧠📊 Register today: alz-org.zoom.us/webinar/regi...

021

Jet M.J. Vonk, PhD PhD @jetmjvonk.bsky.social · 27/02/2025

On behalf of @istaart.bsky.social Design and Data Analytics PIA: JUST OUT—Klee et al. examine multimorbidity contributors to dementia over time. A great international collaboration with researchers from Univ of Luxembourg, OHSU & Yale. Read more: alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

alz-journals.onlinelibrary.wiley.com

Examining multimorbidity contributors to dementia over time

INTRODUCTION Multimorbidity is associated with increased risk of dementia, but previous estimation of the joint contribution of constituent conditions to dementia incidence did not model additive co...

120

Reposted by Jet M.J. Vonk, PhD PhD

Maria Glymour @mariaglymour.bsky.social · 15/02/2025

We need to shout from the rooftops how and why NIH funded health research is important, and what is accomplished with this work: www.bu.edu/sph/news/art... We're not just doing this because we secretly love reformatting our biosketches & spending weekends writing grants. #EpiSky

bu.edu

How Federal Funding Propels the SPH Research Making a Difference in People’s Lives

With federal research funding cuts looming for academia and medical centers across the US, we take at look at how federally funded research at SPH has produced tangible results that benefit real lives...

13217

Jet M.J. Vonk, PhD PhD @jetmjvonk.bsky.social · 13/02/2025

On behalf of the @istaart.bsky.social Design and Data Analytics PIA: Applications are now open for the ΨMCA 2025 Conference on data harmonization & synthetic data in cognitive aging research. 📅 Aug 10–15 2025, Tahoe City, CA. Apply by Feb 28: psymca.org #CognitiveAging #DataScience

psymca.org

Advanced Psychometric Methods for Cognitive Aging Research (ΨMCA) – Psychometric and statistical methods for cognitive aging science

021