Jeff Mugridge @jeffmugridge.bsky.social · 09/07/2026As the lab graduates more PhDs, I'm really feeling just how painful it is to constantly be losing your most senior people! 😭 (that's the goal of course! But it's still tough to always be sending off your best folks who've built up deep expertise on projects and techniques!) 020
Jeff Mugridge @jeffmugridge.bsky.social · 29/06/2026💥 Final version of our Elp3 paper is now live @natcomms.nature.com! We show how the radical SAM enzyme Elp3 uses a molecular tunnel to transport acetate molecules and modify tRNA! We think our proposed mechanism answers long-standing questions about how this important enzyme works! rdcu.be/fq2bwrdcu.beElp3 uses a conserved molecular tunnel to transport acetate between distant active sites and catalyze tRNA wobble base modificationNature Communications - tRNA modifications are essential for accurate translation, but how Elp3 catalyses them across distant active sites was unclear. Here, the authors show that Elp3 uses a... 171
Reposted by Jeff MugridgeStand Up for Science! @standupforscience.net · 16/09/2025DUCK AROUND, FIND OUT! With our duck delivery in tow, we waddled up to the Hill to let our representatives know that it's time to send the Quack-In-Chief packing. #ImpeachRFK 725759
Reposted by Jeff MugridgeScott Delaney @scott-delaney.bsky.social · 16/06/2025THIS IS IT! THIS IS HUGE!! PLAINTIFF'S WIN!! Judge Young rules that the NIH grant terminations at issue in these cases are illegal and therefore vacated. BOOM! 121574366
Reposted by Jeff MugridgeGregg Gonsalves @gregggonsalves.bsky.social · 14/06/2025We are just getting started. “American Spring? How nonviolent protest in the US is accelerating…” wagingnonviolence.org/2025/06/amer...wagingnonviolence.orgAmerican Spring? How nonviolent protest in the US is acceleratingContrary to conventional wisdom, anti-Trump protests this year have dwarfed 2017 in size, and they have been extraordinarily peaceful. 423646
Jeff Mugridge @jeffmugridge.bsky.social · 14/06/2025LOTS of people and LOTS of energy for #NoKings in Newark DE! ❌👑❌ @indivisiblenewark.bsky.social 1112
Reposted by Jeff MugridgeJenna Norton @jenna-m-norton.bsky.social · 10/06/2025Please sign on and add your voice in calling for an NIH that prioritizes the safety of research participants and public health over political momentum. actionnetwork.org/forms/add-na...actionnetwork.orgADD YOUR NAME: Sign the Open Letter in Support of NIH StaffJoin the courageous and committed National Institutes of Health (NIH) public servants by adding your name now. 922786
Jeff Mugridge @jeffmugridge.bsky.social · 04/06/2025My favorite is the 'world tour' tee shirt 🤣🤣 Looking forward to this GRC! 141
Reposted by Jeff MugridgeRachel W. Martin @rwmartin.bsky.social · 10/05/2025Without basic science, there is nothing to translate. 05420
Jeff Mugridge @jeffmugridge.bsky.social · 08/05/2025💥Latest preprint from our lab is now live! We propose a crazy(!?) new mechanism for how the radical SAM enzyme Elp3 (a subunit of the Elongator complex) modifies tRNA! #RNAsky #enzymes 🧵... 2167
Reposted by Jeff MugridgeJordan Meier @doc-jlmeier.bsky.social · 10/04/2025Great news: NIH postbac program is recruiting again! If your grad school plans were affected by program cutbacks or admissions freezes this year I highly encourage you to apply, this could be a perfect opportunity. Please repost. www.training.nih.gov/research-tra...training.nih.gov 6207195
Jeff Mugridge @jeffmugridge.bsky.social · 09/04/2025Yes, thanks to @aaup.bsky.social and others! 1254
Reposted by Jeff MugridgeStand Up for Science! @standupforscience.net · 08/04/2025📣 GET IN, DORKS! We are going protesting...AGAIN! 📣 This time we are standing up for our core value of academic freedom and asking university leadership to STAND UP WITH US against Trump's attack on higher ed ✊ #StandUpWithUS Register/find an event: actionnetwork.org/event_campai... 6469195
Reposted by Jeff MugridgeMax Kozlov @maxkozlov.bsky.social · 04/04/2025🚨 BIG week for lawsuits against the NIH. Now 16 states have sued NIH and HHS for "engag[ing] in a concerted, and multi-pronged effort to disrupt NIH’s grants." "The result of these disruptions has been, in a word, devastating," they write. ag.ny.gov/press-releas...ag.ny.govAttorney General James Sues Trump Administration for Illegally Cutting Funding for Medical ResearchNEW YORK – New York Attorney General Letitia James and a coalition of 15 other attorneys general today filed a lawsuit against the Trump administration for its 514864
Reposted by Jeff MugridgeSmithLabUMBC @smithlabumbc.bsky.social · 28/03/2025Our 28-yr U-RISE/MARC NIH grant that has served over 500 students and made us one of the top institutions producing African American students who go on to receive MD/PhDs in the United States was just cancelled yesterday. What a unnecessary and tragic end to such an impactful program... 54027
Reposted by Jeff MugridgeJoshua Weitz @joshuasweitz.bsky.social · 28/03/2025Working with an interdisciplinary team, we have developed a website to communicate how the White House's proposed cuts to health research would cause losses of $16B and 68,500 jobs. Find out how your community may be impacted. Explore more at SCIMaP: scienceimpacts.org a 🧵 19664613511
Reposted by Jeff MugridgePhilip Gourevitch @pgourevitch.bsky.social · 19/03/2025powerful detailed account of ICE captivity "To put things into perspective: I had a Canadian passport, lawyers, resources, media attention, friends, family and even politicians advocating for me...Imagine what this system is like for every other person in there" www.theguardian.com/us-news/2025...theguardian.comI’m the Canadian who was detained by Ice for two weeks. It felt like I had been kidnappedI was stuck in a freezing cell without explanation despite eventually having lawyers and media attention. Yet, compared with others, I was lucky 20167212739
Jeff Mugridge @jeffmugridge.bsky.social · 15/03/2025Me, leaving the US for a conference in Europe. 090
Jeff Mugridge @jeffmugridge.bsky.social · 07/03/2025Great crowd and a great time at #StandUpForScience DC today at the Lincoln Memorial! @standupforscience.bsky.social Photos… 🧵 1677
Reposted by Jeff MugridgeCantlonLab @cantlonlab.bsky.social · 07/03/2025Write for @sciencehomecoming.bsky.social A major property of communication is that only repeated messages stick. Even if there’s already an op-ed on science funding in your town, adding more makes an impact. After we @standupforscience.bsky.social today, let’s write to bring it home. 🧪🏠 0176
Jeff Mugridge @jeffmugridge.bsky.social · 06/03/2025Ready to #StandUpForScience tomorrow in DC! Let’s go! @standupforscience.bsky.social 1142
Jeff Mugridge @jeffmugridge.bsky.social · 04/03/2025Anyone have tips for making active homemade Phusion polymerase? We have a plasmid (no his tag), and are doing purification by heat denaturation and then sizing, from which we get *a lot* of purified protein. But we can't see any polymerase activity from these purified preps! 111
Jeff Mugridge @jeffmugridge.bsky.social · 03/03/2025Let's go! Looking like a great Friday in DC! I'll be there! 000
Reposted by Jeff MugridgeScience Homecoming @sciencehomecoming.bsky.social · 27/02/2025Happy Homecoming to Biochemistry Professor and High School Science Olympian Jeff Mugridge from Central New York who wrote for The Post Standard about the rewards of science funding for NY health and economy 🍎 🧪🧬🔬🏠@jeffmugridge.bsky.social www.syracuse.com/opinion/2025...syracuse.comProtect science funding driving innovation, investment in Syracuse (Guest Opinion by Jeffrey Mugridge)Severe cuts to budgets and staff threaten to undermine the next generation of American scientists, writes professor who discovered his love of science as a Liverpool High student. 0116
Jeff Mugridge @jeffmugridge.bsky.social · 27/02/2025I wrote an opinion piece for my hometown newspaper in Central NY about attacks on NIH/NSF/research and why this harms not just US science but local jobs and economies. Thanks @sciencehomecoming.bsky.social for sparking these efforts! I encourage others to join in! www.syracuse.com/opinion/2025...syracuse.comProtect science funding driving innovation, investment in Syracuse (Guest Opinion by Jeffrey Mugridge)Severe cuts to budgets and staff threaten to undermine the next generation of American scientists, writes professor who discovered his love of science as a Liverpool High student. 075
Reposted by Jeff MugridgeSenator Lisa Blunt Rochester @bluntrochester.senate.gov · 21/02/2025These NIH funding cuts threaten research happening in Delaware on heart disease, cancer, diabetes, stroke recovery, & more. This is what this administration is focused on. Not lowering your household costs.delawarebusinesstimes.comDelaware’s innovation pipeline could be at risk with new NIH funding policyWith a proposed cap on indirect costs for NIH grants, Delaware's life science sector could be hit the next generation of start-ups and researchers. 511859582
Reposted by Jeff MugridgeScott Delaney @scott-delaney.bsky.social · 21/02/2025NIH indirects case update: Hearing ongoing now, and I'll try to live tweet some notable exchanges. Prior to more detailed arguments, Judge Kelley starts off with a few point questions to both sides: (I'm paraphrasing here) 14347196
Jeff Mugridge @jeffmugridge.bsky.social · 21/02/2025um what? ...every grant recipient affected by indirect cuts can just sue? Yes, no problem there.🤣 Totally insane 020
Reposted by Jeff MugridgeStand Up for Science! @standupforscience.net · 20/02/2025#StandUpforScience2025 in the Boston Globe! 🌎 www.bostonglobe.com/2025/02/20/m...bostonglobe.comIn ‘Stand Up For Science,’ researchers aim to get loud and push back - The Boston GlobeInspired by the 2017 March for Science that drew millions, organizers are planning rallies in Washington D.C., Boston and other state capitals. 28432
Reposted by Jeff MugridgeThe Onion @theonion.com · 20/02/2025Happy Person Must Either Be Stupid Or Evil theonion.com/happy-p... 10177281114
Reposted by Jeff MugridgeDr. Becca @docbecca.bsky.social · 20/02/2025Glad to see this post getting some traction, because the Federal Register is the WHOLE ballgame, folks. To drive this point home, a recent EO declares that all posts to FR now must be approved by the White House. www.whitehouse.gov/presidential...whitehouse.govEnsuring Accountability for All AgenciesBy the authority vested in me as President by the Constitution and the laws of the United States of America, it is hereby ordered: 5117115
Reposted by Jeff MugridgeShonna McBride @shonmcbride.bsky.social · 18/02/2025Courage is contagious! #CDC #SAVEUSSCIENCE #ATL 054
Jeff Mugridge @jeffmugridge.bsky.social · 13/02/2025Really illuminating breakdown on direct and indirect cost calculations. Although the administration is trying to burn down the NIH, NSF, other govt-funded science, and US research universities, at least I'm learning a lot about federal science funding 😅😭media.tenor.coma man in a plaid shirt and tie is typing on a computer keyboard while a fire is behind him .Alt: Learning stuff during a fire: a man in a plaid shirt and tie is typing on a computer keyboard while flames burn around him. 030
Reposted by Jeff Mugridgejunhyongkim.bsky.social @junhyongkim.bsky.social · 09/02/202560% indirect = 60/160 = 37.5% overhead. 15% indirect = 15/115= 13% overhead. A restaurant: Direct: raw ingredients + cook Indirect: everything else A car co: Direct: parts + assembly workers Indirect: everything else A newspaper: Direct: paper, ink, reporters Indirect: everything else 0147
Reposted by Jeff MugridgeCatherine Rampell @crampell.bsky.social · 08/02/2025NIH cuts billions of dollars in biomedical funding, effective immediately. The move halts a large slice of money for most universities and research institutions virtually overnight, imperiling vital research in everything from cancer to heart disease. www.washingtonpost.com/health/2025/...washingtonpost.comNIH cuts billions of dollars in biomedical funding, effective immediatelyThe move halts a large slice of money for most universities and research institutions virtually overnight, imperiling vital research in everything from cancer to heart disease. 31348311865
Jeff Mugridge @jeffmugridge.bsky.social · 08/02/2025Yes - slashing indirect costs on research grants isn’t some wonky attack on Universities, it’s an attack on *all* Americans 000
Jeff Mugridge @jeffmugridge.bsky.social · 08/02/2025A critical point👇, that Universities typically *lose* money on doing research. The indirect costs that NIH pays to Unis for research grants are not some amazing source of revenue… they just make it (barely) sustainable to support the science research that drives huge amounts of US innovation 012
Jeff Mugridge @jeffmugridge.bsky.social · 08/02/2025Really hoping the courts will indeed stop the complete destruction of US research universities 🤞🤞🤞 041
Jeff Mugridge @jeffmugridge.bsky.social · 29/01/2025Oh, great 😒 ...and here I thought we might have a brief reprieve from existential dread today 110
Reposted by Jeff MugridgeYi Tang @yitangucla.bsky.social · 29/01/2025First post on Blue sky! Congratulations to graduate student Yorick Chiang and scientist Masa Ohashi on discovery of new copper dependent halogen from Nature @nature.com ! Many thanks to the wonderful collaborators! www.nature.com/articles/s41...nature.comCopper-dependent halogenase catalyses unactivated C−H bond functionalization - NatureA halogenase enzyme uses the copper in its active site to catalyse iterative chlorinations on multiple unactivated carbon−hydrogen bonds, enabling carbon−hydrogen functionalization that is not achieva... 22910
Reposted by Jeff MugridgeJeremy Berg @jeremymberg.bsky.social · 28/01/2025Academic Skyers: I am compiling a list of policies and statements from various universities about how they are handling the "pause" in terms of stopping expenditures (or not). Please respond to this post with your institution and materials. THANK YOU! 139713385
Reposted by Jeff MugridgeJeff Coller @jmcoller.bsky.social · 27/01/2025CleanCap M6 inhibits decapping of exogenously delivered IVT mRNA: Molecular Therapy Nucleic Acids www.cell.com/molecular-th...cell.comCleanCap M6 inhibits decapping of exogenously delivered IVT mRNAIn this manuscript, Mandell and colleagues present CleanCap M6, a next generation 5’ cap analog that outperforms existing industry standards in live mice. Mandell and colleagues found that this cap ex... 0135