iiinova — where your digital self keeps evolving

Reposted by Jeffrey Barrett

Nicky Whiffin @nickywhiffin.bsky.social · 30/09/2026

Excited to share our new preprint "A cross-tissue splicing signature as a quantitative biomarker for ReNU syndrome" tinyurl.com/RENUsig Led by super⭐ duo @ruebenadawes.bsky.social @alexblakes.bsky.social We show that just 6 alternative 5'splice site events perfectly predict ReNU syndrome 🧬 🧵 1/4

A panel of 4 plots.
Top left: a bar plot of LASSO coefficients for the six 5' splice site events chosen by the model.
Top right: Box plots showing the LASSO predicted probability of case status for controls compared to ReNU cases across whole-blood and lymphocyte cohorts, for training and test samples. P(case) for ReNU samples are significantly greater than controls.
Bottom left: schematics of the six alternative 5' splice site events.
Bottom right: Box plots showing significant changes in expression for two of the implicated genes, STX16 and RPS15A.

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Jeffrey Barrett @jeffbarrett.eu · 01/10/2026

The short answer is I live in Finland. More concretely: to speak Finnish with my kids when they feel like it (they are bilingual), to deal with the school system and certain admin, and to make closer friends. I'm stuck because I'm afraid of messing up. (I guess I have diagnosed myself 😆)

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Jeffrey Barrett @jeffbarrett.eu · 01/10/2026

I would love to hear about your experience in any level of detail you choose to share! I have been stuck at "not good enough" Finnish for a few years now... :(

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Jeffrey Barrett @jeffbarrett.eu · 29/09/2026

Read a bit of @emilyrcwilson.bsky.social’s Odyssey to my 8-year old tonight (book 10, Aeolus and Circe are more exciting than the suitors). And, WOW, is this meant to be read aloud. The verse just cooks in a way you can’t replicate inside your head.

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Jeffrey Barrett @jeffbarrett.eu · 29/09/2026

I like to keep Claude on its toes by mixing wildly different topics in the same chat. For example, this reply came in a chat titled, "Montreal steakhouses": "The mixing parameter α is worth tuning jointly with λ, though results are often fairly flat across α in a moderate range like 0.3 to 0.7."

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Reposted by Jeffrey Barrett

Caroline Bartman @cbartman.bsky.social · 26/09/2026

Are there key discoveries made with spatial RNA seq? Or what are your favorite spatial rna seq papers? Pls reski!

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Ryan Moulton @moultano.bsky.social · 26/09/2026

More hugging face details derived from public urls. swarmtraces.org

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Jeffrey Barrett @jeffbarrett.eu · 25/09/2026

God that's fucking grim. Imagine laboring over a grant submission and then finding out no human ever even read it. I have some sympathy for funding agencies trying to cope with a wave of AI generated submissions, but this does not seem like a good sign.

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Jeffrey Barrett @jeffbarrett.eu · 24/09/2026

I wonder if worker agents complain about their supervisor agents behind their backs. Do they have agent development discussions about their career prospects?

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Reposted by Jeffrey Barrett

Get To Know Nature @gettoknownature.bsky.social · 23/09/2026

A juvenile Cooper’s Hawk outside the dining room window for the #BirdOfTheDay. #raptors #birds 🌿

Close up photo of a brown and white streaked bird of prey looking intense.

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Jeffrey Barrett @jeffbarrett.eu · 22/09/2026

P.S. lest you think I’m just excitable, the ! is in the name.

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Jeffrey Barrett @jeffbarrett.eu · 22/09/2026

Pirates! on my friend’s Mac. We had a NES before that, and I liked playing it, but it always felt more like my (older) brother’s thing. Strategy plus the thrill of leaping across the gunwale for hand to hand combat. Also the beginning of a lifelong enjoyment of Sid Meier’s oeuvre

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Reposted by Jeffrey Barrett

ELLIS Institute Finland @ellisinstitute.fi · 22/09/2026

Detecting diseases earlier with the help of AI: introducing @jeffbarrett.eu, one of our new principal investigators and professor at @helsinki.fi + @fimm-uh.bsky.social. “Helsinki brings together AI expertise and world-class biobank and health registry data." www.ellisinstitute.fi/meet-our-new...

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Reposted by Jeffrey Barrett

womensartbluesky.bsky.social @womensartbluesky.bsky.social · 19/09/2026

Lisa Noonis, contemporary US painter based in Maine #WomensArt

Painting of a stylised perched white bird with small yellow beak against a blue backgrojnd

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Institute for Molecular Medicine Finland (FIMM) @fimm-uh.bsky.social · 18/09/2026

Meet @jeffbarrett.eu, new Professor of Computational Predictive Medicine @helsinki.fi & @ellisinstitute.fi! Barrett's career spans genomics, public health and industry. His research focuses on using AI to analyse large-scale health data to discover new biomarkers. 🔗 www.helsinki.fi/en/news/publ...

helsinki.fi

Jeffrey Barrett develops ways to detect disease earlier and more precisely | University of Helsinki

Computational predictive medicine aims to develop ways to detect diseases as early as possible, so that patients can receive personalised treatment while their symptoms are still mild.

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Jeffrey Barrett @jeffbarrett.eu · 16/09/2026

I have no expectation about whether the cover letter sounds like English as a first language. I’m an immigrant and am acutely aware of how it feels to not speak the local language fluently! I just want to hear in simple sentences what is scientifically interesting!

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Jeffrey Barrett @jeffbarrett.eu · 16/09/2026

First opportunity to join my new lab! Deadline is in <1 week, but applying only needs a CV and cover letter. (See previous tweet for advice on how (not) to write the cover letter) www.ellisinstitute.fi/postdoc-and-...

ellisinstitute.fi

Postdoc and doctoral student positions at ELLIS Institute Finland | ELLIS Institute Finland

Apply to join the Institute research groups!

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Jeffrey Barrett @jeffbarrett.eu · 15/09/2026

Tempted to use AI to write your cover letter or email to a potential employer? RESIST! It is simultaneously obvious, insulting, and renders you totally undifferentiated from the other 80 people being considered t the same time. There has never been a better time to write concisely in your own voice!

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Reposted by Jeffrey Barrett

Gen Wojcik @genandgenes.bsky.social · 15/09/2026

Come join us in Montreal at ASHG this year! And stick around to the end to hear the Distinguished Speakers Symposium "Globalizing Human Genetics: From Discovery Through Implementation" with Eimear Kenny, Gonçalo Abecasis, Pradeep Natarajan, and yours truly!

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Jeffrey Barrett @jeffbarrett.eu · 13/09/2026

Reflecting on it 40 years later from another country, it’s a _weird_ ritual, especially for children.

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Jeffrey Barrett @jeffbarrett.eu · 12/09/2026

The PROFILE trial of top-down infliximab in Crohn's disease has reported dramatic results over 5 years of follow up. My thoughts here: barrettlab.eu/blog/profile/ www.sciencedirect.com/science/arti...

barrettlab.eu

Using the drugs we have more effectively | Barrett Lab @ University of Helsinki

The readout of the PROFILE trial after 5 years shows dramatic benefit from top-down treatment for Crohn's disease.

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Reposted by Jeffrey Barrett

Elle Cordova @ellecordova.bsky.social · 08/09/2026

I am the very model of a modern day typographer A font take on the tune “Modern Major General” by Gilbert & Sullivan #typography #fonts #graphicdesign

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Jeffrey Barrett @jeffbarrett.eu · 08/09/2026

This is awesome but that AI narration is unforgivable. I demand you re-record the narration in your own voice!

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Jeffrey Barrett @jeffbarrett.eu · 06/09/2026

Both stories are just perfect.

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Reposted by Jeffrey Barrett

Helen Barrett @helenbarrett.bsky.social · 06/09/2026

So engrossed in this I've missed by tube destination by three stops.

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Jeffrey Barrett @jeffbarrett.eu · 04/09/2026

WTF is wrong with Slack that by default they opt you into an email summary of unread messages of every workspace you join.

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Jeffrey Barrett @jeffbarrett.eu · 02/09/2026

Without saying your age, what is your favorite movie that came out when you were 20 years old?

static.klipy.com

Maximus: Are You Not Entertained?

Alt: Maximus: Are You Not Entertained?

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Jeffrey Barrett @jeffbarrett.eu · 02/09/2026

"we find minimal spousal assortment for personality in recent history" 🤣

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Jeffrey Barrett @jeffbarrett.eu · 02/09/2026

Congratulations, man. Terrific work!

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Jeffrey Barrett @jeffbarrett.eu · 01/09/2026

This mix has absolutely carried me through a month of grant writing. Caught in Joy is generally awesome, but I have felt the need for the extra kick of this playlist compared some of his more chill examples. cc @michelnivard.bsky.social youtu.be/azH0gSbQ73g?...

youtu.be

Music to Feel Alive Again

YouTube video by Caught In Joy

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Jeffrey Barrett @jeffbarrett.eu · 31/08/2026

Wow that’s a helluva session line up!

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Jeffrey Barrett @jeffbarrett.eu · 31/08/2026

I have heard of Piker and Alix Earle, but have not to my knowledge seen any of their content. The other 23 are tabula rasa. 💪

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Jeffrey Barrett @jeffbarrett.eu · 30/08/2026

Wow, fanstastic work. And beautiful slides!!

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Reposted by Jeffrey Barrett

Bloom lab @jbloomlab.bsky.social · 30/08/2026

Here is a link to slides I will present today at Options XIII Conference for Control of Influenza meeting: slides.com/jbloom/optio... Slides describe using sequencing-based neutralization assays to characterize human neutralizing antibody landscape to seasonal influenza virus in near real time

slides.com

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Jeffrey Barrett @jeffbarrett.eu · 29/08/2026

Or is he chalking up every heart attack as a “food induced illness”?

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Jeffrey Barrett @jeffbarrett.eu · 29/08/2026

Also, WTF is he talking about? The USA has ~3M deaths / year. Did he change the denominator to the whole world halfway through the sentence?

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Jeffrey Barrett @jeffbarrett.eu · 28/08/2026

I'm glad you looked at it with your own peepers instead of through a lens! 🌔

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Jeffrey Barrett @jeffbarrett.eu · 28/08/2026

"In fact, it is now conceivable that our children's children will know the term cancer only as a constellation of stars." Bill Clinton's speechwriter (announcing completion of the human genome project) was pretty good. Anybody know who it was?

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Jeffrey Barrett @jeffbarrett.eu · 28/08/2026

I mean nobody's gonna argue the Napoleon of the stump is near great.

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Jeffrey Barrett @jeffbarrett.eu · 28/08/2026

I think my favorite part of this is Grover Cleveland as near-great.

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Reposted by Jeffrey Barrett

Randall Munroe @xkcd.com · 27/08/2026

Particle Physics Equipment xkcd.com/3286/

Comic: Particle Physics Equipment by how much it sounds like an offering at a high-end spa in a sci-fi/fantasy novel. Line graph increasing to the right. Geiger counter, Cherenkov detector, Photomultiplier tube, linear accelerator, scintillation counter. [small gap] Ion chamber [small gap] Cyclotron [extremely large gap] Bubble chamber, cloud chamber.

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Reposted by Jeffrey Barrett

Richard Sever @richardsever.bsky.social · 27/08/2026

$3.7 billion spent on APCs in 2025. That's ~1000X more than it costs to run bioRxiv/medRxiv. Worth thinking about as we consider how to fund infrastructure... arxiv.org/pdf/2608.16322

arxiv.org

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public health guy @publichealthguy1.bsky.social · 24/08/2026

i’m dying. i’m dead

zohran holding a the power broker book up in front of his face. caption reads “but robert moses is another video entirely)

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Jeffrey Barrett @jeffbarrett.eu · 24/08/2026

Spot on. Writing a paper does two things: 1. shares your work with the world; 2. helps you think more clearly about your work. Using AI to write wipes out (2). See also: using a forklift at the gym www.schneier.com/blog/archive...

schneier.com

Should You Use AI for a Task? Here’s a Simple Way to Decide - Schneier on Security

This essay originally appeared in The Guardian. I teach public policy at the Harvard Kennedy School and the Munk School at the University of Toronto. And it will come as no surprise to you that my stu...

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Jeffrey Barrett @jeffbarrett.eu · 21/08/2026

I am not an expert, but I don't think it's oncogenes that are targeted by vaccines, but rather those that present T-cell recognisable neoantigens. So even though drivers are recurrent between patients, the vaccine targets (which can be drivers or passengers) aren't. www.nature.com/articles/s41...

nature.com

Identification of neoantigens for individualized therapeutic cancer vaccines - Nature Reviews Drug Discovery

Mutations in cancer cells can generate tumour-specific neoepitopes, which are attractive targets for anticancer vaccines. This Review discusses the mechanisms of neoantigen T cell recognition and comp...

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Reposted by Jeffrey Barrett

Ben Fry @benfry.com · 19/08/2026

Throwback from 2001… Had to revive an old project for an upcoming show, and in the process, ran across this old poster from around the same time.

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