Plasmids drive bacterial adaptation, but how their diversity arises has remained unclear. Here, they show that in Staphylococcus aureus, mobile genetic elements repeatedly fuse and delete plasmids, re...

In this study, authors investigate the evolution of bacterial resistance to antisense peptide nucleic acid (PNA) antibiotics. They observe that this typically occurs mainly by reducing drug uptake via...

The Selfish Gene continues to challenge readers half a century later

This is the official web page for the Microbial Pangenomes Lab at Twincore.

Hospital settings can act as reservoirs for pathogens, with many nosocomial bacteria surviving for extended periods of time and spreading via contaminated environments, healthcare workers, or medical ...

A snakelike pipeline combining ggCaller and Panaroo. - samhorsfield96/ggCallaroo

⚡♠️ Assemble bacterial isolate genomes from Illumina paired-end reads - tseemann/shovill

The 2024 WHO BPPL is a key tool for prioritising research and development investments and informing global public health policies to combat AMR. Gram-negative bacteria and rifampicin-resistant M tuber...

Bacteria use gene regulation to dynamically adapt to changes in their environment, including resistance to stress and the occupation of new niches. Gene expression is known to vary within a species pa...

Antimicrobial resistance (AMR) is one of the most pressing global health problems, with plasmids playing a central role in its evolution and dissemination. Over the past decades, many studies have inv...

npj Antimicrobials and Resistance - Emergence of transferable daptomycin resistance in Gram-positive bacteria

Author summary Antibiotic resistance is an important public health threat: resistant infections are currently associated with 5 million deaths per year globally. This burden may increase further in th...

Each bacterial species has not just a single genome, but a diverse ensemble of gene combinations. This means that the properties of bacteria are constantly changing – for example, how ill they can mak...

Identifying genetic variants associated with bacterial phenotypes, such as virulence, host preference and antimicrobial resistance, has great potential for a better understanding of the mechanisms inv...