Taking a scientific approach to artificial-intelligence queries makes every output a result to be checked, says James Dewar. Here are ten tips for doing it right.

Centromeric DNA repeat insertions and CENP-A chromatin assembly are identified as genomic signatures that preserve telomere integrity in ALT cancer cells.

Here the authors show that collapse of single replication forks causes recombination, end fusions or degradation but does not restart DNA synthesis. In contrast, collapse of convergent forks completes...

DNA replication generates topological stress that must be relaxed and molecular entanglements that must be resolved. Unwinding of the parental duplex creates po

Apurinic/apyrimidinic (AP) sites, also known as abasic sites, are among the most frequent DNA lesions, arising spontaneously or as intermediates in base excision repair. Their structural impediment to...

PhD Project - Identifying bacterial DNA repair requirements enabling stable genetic inheritance during bidirectional replication fork collapse at Newcastle University, listed on FindAPhD.com

Markiewicz-Potoczny et al. report that the nonsense-mediated mRNA decay pathway protects telomeres in the absence of core Shelterin component TRF2 by regulating the stability and abundance of TRF1 at ...

@DamonRunyon.org Timmerman Traverse Fellow w Agnel Sfeir at MSK • PhD in Dewar lab @vanderbilt.edu • from Tbilisi, Georgia 🇬🇪 basic scientist fascinated by mtDNA+🏔️⛷️🎭🗽

Replication fork collapse at single-strand DNA breaks (SSBs) poses a serious threat to genome stability. Using Xenopus egg extracts, we show that a replication fork encountering an SSB on either the l...

Abasic sites are one of the most frequent forms of DNA damage that interfere with DNA replication. However, abasic sites exhibit complex effects because they can be processed into other types of DNA d...