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JAMA Psychiatry @jamapsychiatry.com · 01/10/2026

Developmental changes in GRIN2A expression may help explain the timing of psychosis in #Schizophrenia and support stage-specific and genetically informed treatment approaches. ja.ma/4yvYbz6

Graph plots NR2A expression vs. age. Midbrain dopamine regions (orange) peak in childhood & decline. Neocortex/hippocampus (blue) remain high. A dashed line shows "Experimental reduction of Grin2A in DA cells" from adolescence, leading to lower expression and "Emergence of psychosis."

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JAMA Psychiatry @jamapsychiatry.com · 30/09/2026

A context-sensitive road map for #MentalHealth system scale-up indicates that governance, supervision, referral pathways, monitoring, and local adaptation are necessary for sustainable implementation. ja.ma/4hqhhyY

Flowchart: 4-step program scale-up. Starts with Local Context. Steps: 1) Assess needs & readiness (Governance, Workforce, Safeguards), 2) Codesign/adapt, 3) Integrate/expand (via clinics, community, faith groups), 4) Institutionalize/sustain. Ends with 6 Accountability Indicators.

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JAMA Psychiatry @jamapsychiatry.com · 30/09/2026

US #MentalHealth and #SubstanceUseDisorder expenditures totaled $174 billion in 2021-2023, or 7.0% of all medical spending, with ambulatory services accounting for the largest share. ja.ma/4hmVBFt

A JAMA Psychiatry article page titled 'Mental Health and Substance Use Disorder Expenditures in the US' by Carlos Blanco, Chandler McClellan, Samuel H. Zuvekas, et al. Published online September 30, 2026. DOI: 10.1001/jamapsychiatry.2026.3120.

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JAMA Psychiatry @jamapsychiatry.com · 25/09/2026

Maternal #PlacentalGrowthFactor trajectories diverged in the third trimester in pregnancies where children were later diagnosed with #ADHD, while endothelin-1 did not differ. ja.ma/4yPn6wW

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JAMA Psychiatry @jamapsychiatry.com · 25/09/2026

💬 Viewpoint: In #Psychiatry, care for #Deaf and hard-of-hearing patients requires clinical competency because hearing loss, signed language, and social bluffing can complicate the Mental Status Examination and affect diagnosis. ja.ma/47cOyJh

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JAMA Psychiatry @jamapsychiatry.com · 25/09/2026

💬 Viewpoint: A special collection in #Psychiatry highlights early-career investigators studying clinical equity, structural #MRI and machine learning, ultraprocessed foods and depression, and placental growth factor trajectories. ja.ma/4rrJolZ

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JAMA Psychiatry @jamapsychiatry.com · 25/09/2026

Structural #MRI with machine learning estimated individual delay discounting in college-aged participants, with white matter volumes showing stronger performance than gray matter volumes. ja.ma/3TMXbXY

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JAMA Psychiatry @jamapsychiatry.com · 25/09/2026

In patients with #Depression and high #UltraprocessedFoods intake, a low-ultraprocessed-food diet was feasible and acceptable, and depressive and anxiety symptoms were lower during the intervention period vs a regular diet. ja.ma/4xIUhBI

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JAMA Psychiatry @jamapsychiatry.com · 17/09/2026

Many studies using #Neurodivergent or #Neurodiverse terminology identified participants through self-report or self-identification, and some did not specify any diagnosis. Precise diagnostic descriptors may improve clinical research and practice. ja.ma/471eTKf

Table 2 displays clinical diagnoses where neurodiverse/neurodivergent terminology was applied. Autism (68.66%) and ADHD (64.18%) were most common. Dyslexia followed at 32.84%. Many other conditions are listed, with 21.64% of studies not defining it clinically.

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JAMA Psychiatry @jamapsychiatry.com · 16/09/2026

📝 Viewpoint: High-dose #psychedelic #clinicaltrials remain poorly masked, which limits isolation of pharmacological effects from expectancy effects. More aggressive active comparators and reduced disclosure may strengthen causal inference. ja.ma/4gX0swJ

Line graph plots pharmacological comparators for psilocybin trials by experiential intensity (x-axis) and breadth of psychedelic experience (y-axis). Psilocybin 25mg and a multidrug combination score highest. Other drugs like THC, DXM, Zolpidem, Amphetamine salts, and Salvinorin A show varying positions from low to high intensity/breadth.

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JAMA Psychiatry @jamapsychiatry.com · 16/09/2026

Among women with #BulimiaNervosa, structural #MRI identified lower nucleus accumbens volume and lower temporal cortical surface area vs healthy control individuals, supporting altered reward and social cognition circuits. ja.ma/477nBql

Two 3D brain plots show cortical surface areas. Yellow-green highlighted regions indicate lower mean surface area in participants with more frequent binge eating, corresponding to negative r values on the color scale from -1.0 to 1.0.

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JAMA Psychiatry @jamapsychiatry.com · 09/09/2026

In a Danish cohort, parental similarity for #PsychiatricDisorders was substantial and was associated with higher prevalence and higher family-based heritability than expected under random mating. ja.ma/3TpVqjj

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JAMA Psychiatry @jamapsychiatry.com · 07/09/2026

💬 Viewpoint: In #Psychiatry, large language models should be used as clinical instruments, with clinician accountability and source-grounded verification before output influences care. ja.ma/4xeSxQq

A flowchart titled "Specify-Elicit-Interrogate-Ground (SEIG) Loop." It shows four steps: 1. Specify (Define task, audience, sources, format). 2. Elicit (Request facts, inferences, unknowns). 3. Interrogate (Ask for counter cases, biases). 4. Ground (Link claims to date, scale, collateral, or state 'not in record').

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JAMA Psychiatry @jamapsychiatry.com · 06/09/2026

💡 Special Communication: In psychiatry, #PolygenicScores, rare variant testing, and #Pharmacogenomics may have value when used selectively to inform diagnosis, prognosis, monitoring, and medication safety rather than population-wide screening. ja.ma/3UD8l1I

Diagram shows genomic testing informing prevention in psychiatry across mental illness stages. Before diagnostic consolidation, Primary prevention (Universal, Selective, Indicated) occurs. In the Zone of diagnostic uncertainty, PGS/rare variant testing inform diagnosis. After, Secondary/Tertiary prevention, pharmacogenomics guides treatment, & PGS/rare variant testing inform comorbidity.

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JAMA Psychiatry @jamapsychiatry.com · 06/09/2026

Among adults with serious mental illness, #GLP1 receptor agonists vs #SGLT2 inhibitors were associated with lower mortality and fewer major cardiovascular events, with greater absolute benefit in serious mental illness. ja.ma/4r3cmZy

Figure 2: Kaplan-Meier survival curves comparing all-cause mortality for GLP-1 RA and SGLT2 inhibitor initiators over 1460 days. Plot A (serious mental illness) shows GLP-1 RA with better survival (HR 0.76). Plot B (no serious mental illness) also shows GLP-1 RA with better initial survival (HR 0.85) but curves converge.

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JAMA Psychiatry @jamapsychiatry.com · 06/09/2026

💬 Viewpoint: Family-based care for #Psychosis may need to address the digital home, where #SocialMedia and #ArtificialIntelligence shape symptom interpretation, conflict, treatment beliefs, and relapse warning signs. ja.ma/4A0j7zd

Table: 'Digital Home Environments Where Symptoms, Conflict, Safety Concerns, & Recovery Efforts Are Interpreted & Negotiated'. It has columns for 'Digital domain', 'Ask', & 'Task', detailing actions for symptom reinforcement, online emotional climate, boundaries, & engagement with care.

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JAMA Psychiatry @jamapsychiatry.com · 19/08/2026

💬 Viewpoint: #Suicide risk models are advancing, but health systems often lack the infrastructure needed to select, implement, recalibrate, and sustain them in routine care. ja.ma/4zqL9Dz

Framework for scalable suicide risk prediction models. It covers three areas: generalization (federated validation), adoption (site profiling, decision criteria), and advancement (multimodal social determinants). Underpinned by infrastructure standards & stakeholder engagement.

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JAMA Psychiatry @jamapsychiatry.com · 19/08/2026

Among young adults at varying #ManiaRisk, greater left ventrolateral prefrontal cortex activation during reward expectancy was associated with lower delay discounting, consistent with greater sensitivity to reward value. ja.ma/45wROP5

Figure 2, 4 scatterplots. A: L-vlPFC activation and lifetime mania domain show a positive correlation. B: Pre-SMA activation and lifetime mania domain also show a positive correlation. C: L-vlPFC activation and medium-magnitude delay discounting show a negative correlation. D: Pre-SMA activation and medium-magnitude delay discounting show a positive correlation.

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JAMA Psychiatry @jamapsychiatry.com · 15/08/2026

💬 Editorial: Connectivity-based targeting for transcranial magnetic stimulation demonstrated greater antidepressant effects and precision than scalp-based approaches in adults with treatment-resistant #Depression. ja.ma/4hAsSNY

JAMA Psychiatry editorial: "A New Era of Precision Neuromodulation in Psychiatry" by Burak Uzay, Helen S. Mayberg, and Martijn Figee. Published online June 24, 2026. DOI: 10.1001/jamapsychiatry.2026.1026.

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JAMA Psychiatry @jamapsychiatry.com · 13/08/2026

💬 Viewpoint: Longitudinal precision functional mapping combines individualized brain network mapping with repeated imaging to distinguish trait-like illness markers from state-like symptom changes in #Psychiatry. ja.ma/4qartja

A-D compare brain imaging for symptom dynamics & target specificity. Top row (A, B): Sparse/dense neuroimaging uses group map brains & U-shaped symptom severity graphs (T1 vs T1-T9 data). Bottom row (C, D): Sparse/dense PFM uses PFM brain models with similar U-shaped graphs.

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JAMA Psychiatry @jamapsychiatry.com · 13/08/2026

Family genetic risk scores across 18 psychiatric disorders indicated six correlated factors: psychotic, externalizing, anxiety, neurodevelopmental, mood, and eating disorders. ja.ma/4wWaoMz

Figure. Path Diagram Showing Confirmatory Factor Analysis Results. It displays 6 latent factors (EXT, ND, AD, MDIS, PSY, ED) connected by arrows with correlation values, and influencing multiple observed variables with path coefficients and error variances.

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JAMA Psychiatry @jamapsychiatry.com · 12/08/2026

#SelectiveSerotoninReuptakeInhibitors are an essential component of perinatal mental health care, and treatment decisions in pregnancy should balance risks of untreated major depressive disorder with benefits and potential risks of treatment. ja.ma/4hoQ4hX

Two forest plots. Top: Risk of cardiac malformations with SSRIs. Unadjusted OR 1.25 (1.13-1.38), adjusted for depression & maternal characteristics OR 1.06 (0.93-1.22). Bottom: Risk of ASD with antidepressants. Unadjusted HR 1.81 (1.69-1.92), sibling analysis HR 0.86 (0.60-1.23).

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JAMA Psychiatry @jamapsychiatry.com · 12/08/2026

Machine learning models using periodic health assessment data identified US Army soldiers at elevated risk of subsequent #Suicide and nonfatal #SuicideAttempt, with distinct predictors between the two. ja.ma/4q9KRgp

Table 2: Estimates of Model Performance for Suicide and Nonfatal Suicide Attempt in Test Samples. It lists AUROC, ICI, and Brier scores for SuperLearner, LASSO, elastic net, neural net, random forest, and XGBoost models for both suicide and nonfatal attempt prediction.

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JAMA Psychiatry @jamapsychiatry.com · 12/08/2026

#GLP-1 receptor agonist use and misuse were common among people with #EatingDisorders, with many reporting adverse events, underscoring the need for pharmacovigilance as availability increases. ja.ma/3U8ePFp

Two bar charts on GLP-1 RA use in eating disorders. Chart A shows prevalence of use and misuse: lifetime use 32%, current use 22%, lifetime compounded 10%, lifetime misuse 10%. Chart B shows lifetime use by subtype: BED 55%, AAN 42%, AN 11%, Overall 32%.

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JAMA Psychiatry @jamapsychiatry.com · 11/08/2026

The FDA approved gepirone extended release for #Depression based on 2 positive trials despite 11 negative or inconclusive trials, highlighting the agency's use of regulatory flexibility and trial-level statistical significance. ja.ma/4fM3gMB

Table shows HAMD-17 change analysis for Gepirone ER vs. placebo across 12 trials. Pivotal studies show significant improvement with Gepirone ER (P=.01, .02). Meta-analysis of supportive/pivotal studies combined indicates a treatment difference of -1.22 (95% CI: -1.99 to -0.45, P=.002).

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JAMA Psychiatry @jamapsychiatry.com · 09/08/2026

Disease development trajectories in #MentalDisorders vary by diagnosis at first contact, sex, and age, with younger patients exhibiting more diagnostic shifts and psychiatric contacts, highlighting the need for targeted preventive care. ja.ma/4fNaQqs

A visualization showing mental disorder diagnosis shifts (ICD-10, 2000-2018). It features a dot plot mapping initial diagnoses to later ones, and a flow diagram tracking 7 specific diagnostic groups (like Depression, Schizophrenia, Anxiety) through first, second, and third shifts.

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JAMA Psychiatry @jamapsychiatry.com · 09/08/2026

Among #veterans with #PosttraumaticStressDisorder and distress related to killing in war, impact of killing psychotherapy improved psychosocial functioning and showed greater benefit than present-centered therapy present-centered therapy. ja.ma/3TIH65u

Line graph: SDS total score (0-30) vs. time points (Baseline to Follow-up). PCT (orange circles) and IOK (gray squares) both decrease from ~19-20 at Baseline to ~11-12.5 at TX 10/Post-TX, then slightly rise. IOK generally shows lower scores than PCT.

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JAMA Psychiatry @jamapsychiatry.com · 09/08/2026

💬 Editorial: Reduced temporal stability of #EEG microstates shows promise as a scalable biomarker for predicting clinical outcomes in individuals at high risk for psychosis. ja.ma/45fjk3n

JAMA Psychiatry editorial titled "Electroencephalography Microstates—A Biomarker for Psychosis?" by Marion Brickwedde, Dario Gordillo, and Peter P. J. Uhlhaas. Published online June 3, 2026.

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JAMA Psychiatry @jamapsychiatry.com · 08/08/2026

📝 JAMA Psychiatry #Review: Peripheral #Biomarkers in #Psychiatry depend more on study design than on analytic sophistication, with signal most likely when studies reduce confounding, select reliable phenotypes, and match biomarker use to clinical need. ja.ma/3Slfbbd

Figure 1 from JAMA Psychiatry presents conceptual considerations for useful biomarkers. It includes a diagnostic funnel, examples of biomarker designs, state vs. trait biomarker definitions, and the path of peripheral biomarkers from the brain to a blood sample.

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JAMA Psychiatry @jamapsychiatry.com · 08/08/2026

In #StimulantUseDisorder trials, no medication significantly outperformed placebo for abstinence, but cabergoline supported greater reduced cocaine use when nonabstinence outcomes were included. ja.ma/4fNbzba

Bar graph showing proportion of participants achieving reduced use (blue) and abstinence (orange) in RCTs for Cocaine & Methamphetamine use disorders. Drugs like Tiagabine, Cabergoline, Modafinil, and Bupropion are listed, showing varying percentages for each outcome.

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JAMA Psychiatry @jamapsychiatry.com · 05/08/2026

💬 Viewpoint: In clinical high risk for developing #Psychosis, impaired social functioning is both a predictor of psychosis onset and a major source of disability, supporting trials that measure recovery with person-centered functional outcomes. ja.ma/4cgbuKz

JAMA Psychiatry article page. Title: "Viewpoint: Deconstructing Social Functioning in Psychosis Risk— From Prediction to Recovery." Authors include Ricardo E. Carrión, Benson S. Ku, and Christoph U. Correll. Published Online: August 5, 2026. DOI: 10.1001/jamapsychiatry.2026.2226.

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JAMA Psychiatry @jamapsychiatry.com · 05/08/2026

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JAMA Psychiatry @jamapsychiatry.com · 05/08/2026

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JAMA Psychiatry @jamapsychiatry.com · 29/07/2026

A diagram of the Specify-Elicit-Interrogate-Ground (SEIG) Loop. Step 1: Specify (define task, audience, sources). Step 2: Elicit (request facts, missing data, unknowns). Step 3: Interrogate (ask for counter cases, bias). Step 4: Ground (link claims to sources or state "not in record").

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JAMA Psychiatry @jamapsychiatry.com · 29/07/2026

Among adolescents in substance use disorder treatment who used nicotine #ECigarettes, urine cotinine concentrations increased abruptly beginning in October 2024. ja.ma/4hIXIUi

Scatterplot graphs showing cotinine concentrations Jan 2023-Jan 2025 with model-derived change points (CPs). Graph A: monthly max cotinine with CP in late 2024 as levels rise. Graph B: creatinine-corrected cotinine by nicotine pouch use, showing sharp increases for both reported & not reported use from late 2024, with reported use higher.

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JAMA Psychiatry @jamapsychiatry.com · 29/07/2026

Among patients with prior #SexualViolence, hypervigilance remained the highest #PTSD symptom over time, while negative alterations in cognition and mood recovered most slowly. ja.ma/4wfUNXb

Line graph of PTSD symptom trajectories (rescaled severity) from Week 2 to Month 12 for a group with prior sexual violence. Criterion D (negative alterations in cognition and mood) shows highest severity, decreasing from ~1.85 to ~1.4. Other criteria (hyperarousal, intrusions, avoidance) also decrease, converging around 1.2-1.25.

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JAMA Psychiatry @jamapsychiatry.com · 12/07/2026

Dan-Mircea Mirea, PhD, and John Torous, MD, discuss how receiving more “likes” on social media posts led to greater increases in posting among users with #depression compared to those without depression. 🎧 Listen now: ja.ma/4vs61HE

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JAMA Psychiatry @jamapsychiatry.com · 12/07/2026

Military sexual trauma prevalence remains high among US veterans, especially females, and is associated with increased risk for suicidal thoughts and behaviors. ja.ma/44lGKDV

Figure. Bar graph shows predicted probabilities of suicide-related measures by history of Military Sexual Trauma (MST). For Suicidal ideation: MST is 32% vs No MST 12%. Suicide attempt: MST 16% vs No MST 4%. Suicidal intent: MST 7% vs No MST 1%.

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JAMA Psychiatry @jamapsychiatry.com · 11/07/2026

📄JAMA Psychiatry #Review: Functional unblinding was common in most #psychedelic randomized clinical trials for psychiatric disorders, with >70% correctly identifying treatment allocation, raising concerns for trial validity. ja.ma/4vSymHT

JAMA Psychiatry article: "Blinding Integrity in Psychedelic Randomized Clinical Trials: A Systematic Review." Authored by Diana K. Orsini, Sabrina Wong, Sara Di Luch, et al. Published online April 15, 2026. Includes publication details and DOI.

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JAMA Psychiatry @jamapsychiatry.com · 10/07/2026

Systematic Review: Greater exposure to adverse #SocialDeterminants was associated with #neurobiological abnormalities in #Schizophrenia spectrum conditions, linking SDOHs to clinical outcomes and supporting equity-oriented approaches. ja.ma/4phhfNB

Figure 4: Brain regions associated with social determinants of health shown through MRI. (A) Early life adversity shows widespread activity (green-red, 5-13 articles). (B) Social disconnection, (C) Racism/discrimination, and (D) Poverty show fewer regions (blue-green, 1-5 articles).

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JAMA Psychiatry @jamapsychiatry.com · 10/07/2026

Targeted psychological and psychosocial interventions for #Schizophrenia, including avatar therapy, reduced the severity of #AuditoryHallucinations with small to medium effects and high acceptability. ja.ma/44lg06w

Table 3: Meta-Analytic Results on Dropout Analyses. It displays statistics like risk ratio and proportions for treatment and study dropouts in intervention (IG) and control groups (CG), including k, I²%, I² P value, effect size (with 95% CI), and effect P values.

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JAMA Psychiatry @jamapsychiatry.com · 10/07/2026

In #overweight or #obese patients with #Depression, adjunctive oral #semaglutide reduced effort discounting and improved motivation on a validated effort-expenditure task compared with placebo. ja.ma/4b5knX9

Schematic diagram of an EEfRT trial with 6 laptop screens showing the sequence: (A) Fixation cue (+), (B) Choose task: Probability 50%, Low effort $1.00, High effort $2.37, (C) READY? with checkmark, (D) Completing trial (Space button shown), (E) Feedback: You completed the task!, (F) Reward: You won: $2.37.

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JAMA Psychiatry @jamapsychiatry.com · 05/07/2026

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JAMA Psychiatry @jamapsychiatry.com · 03/07/2026

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JAMA Psychiatry @jamapsychiatry.com · 02/07/2026

💬 Editor's Note by Dost Öngür, MD, PhD: In a randomized clinical trial, semaglutide reduced hemoglobin A1c and body weight and improved physical quality of life in patients with #schizophrenia, #prediabetes, and #obesity, w/o negative effects on mental health. ja.ma/4xZHYSH

JAMA Psychiatry article page featuring 'Editor's Note: Semaglutide in Schizophrenia —A Top Clinical Trial' by Dost Öngür, MD, PhD. Published Online: July 1, 2026. DOI: 10.1001/jamapsychiatry.2026.2043. Includes links for author affiliations & article info.

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JAMA Psychiatry @jamapsychiatry.com · 02/07/2026

In a nationwide Finnish cohort, adolescents exposed to peers’ mental disorder diagnoses and genetic predispositions had increased risk for later mental disorders, especially within school-based peer networks. ja.ma/4feupay

Figure 2: Two error bar plots. A (Externalizing disorders) and B (Internalizing disorders) compare hazard ratios for Peer FGRS (orange) and Peer diagnoses (blue) across four peer networks: Lower/Upper secondary school, 1000-m Square, & Postal code area, showing risk associations.

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JAMA Psychiatry @jamapsychiatry.com · 26/06/2026

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JAMA Psychiatry @jamapsychiatry.com · 25/06/2026

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JAMA Psychiatry @jamapsychiatry.com · 25/06/2026

Individualized, connectivity-based targeting of accelerated transcranial magnetic stimulation produced significantly greater antidepressant effects than scalp-based targeting in adults with treatment-resistant #Depression. ja.ma/4v5sqKI

RCT comparing connectivity-targeted vs. scalp-based aTMS for depression. 40 participants, 22-80y. Graph shows connectivity-targeted aTMS leads to greater MADRS score reduction (24 pts) than scalp-targeted (18 pts) at 1 month post-treatment.

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JAMA Psychiatry @jamapsychiatry.com · 19/06/2026

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