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Aron Jaffe

@jaffeab.bsky.social
82 followers 17 following 66 posts

SVP @ curie.bio; Former SVP Head of Research @chromamedicine; EIR @ThirdRockV; Reg Med, uBiome group leader/Resp DA co-lead @NovartisScience. Opinions my own.

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Aron Jaffe @jaffeab.bsky.social · 27/11/2025
What if RFK Jr. reacted to his cousin’s terminal cancer as JFK reacted to his baby’s death? www.statnews.com/2025/11/26/t... via @statnews.com
statnews.com
What if RFK Jr. reacted to his cousin’s terminal cancer as JFK reacted to his baby’s death?
When President Kennedy’s newborn son died in 1963, it galvanized research. A new Kennedy family tragedy should spur RFK Jr. to support cancer research, not cut it.
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Aron Jaffe @jaffeab.bsky.social · 23/09/2025
www.statnews.com/2025/02/03/v...
statnews.com
Here is how we know that vaccines do not cause autism
Vaccines do not cause autism. You’ve almost certainly read that before — but often without a full explanation of how we know it to be true. Here's how we know.
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Aron Jaffe @jaffeab.bsky.social · 11/09/2025
Congratulations to Mike Welsh @iowamed.bsky.social, Paul Negulescu @vertexpharm.bsky.social, & Jesus Gonzalez on their well-deserved award. If you're not familiar with the path to CFTR therapies, it's worth a read. laskerfoundation.org/winners/comb...
laskerfoundation.org
Triple-drug therapy for cystic fibrosis - Lasker Foundation
Jesús (Tito) González, Paul A. Negulescu, Michael J. Welsh
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Aron Jaffe @jaffeab.bsky.social · 08/09/2025
Reassessment of antibody-based detection of the murine T cell GLP-1 receptor cell.com/cell-metabol... 'Our findings reveal caveats governing use of multiple widely used GLP-1R antibodies, reemphasizing the importance of rigorous antibody validation' Thanks @danieljdrucker.bsky.social & team
cell.com
Reassessment of antibody-based detection of the murine T cell GLP-1 receptor
Glucagon-like peptide 1 receptor (GLP-1R) agonists exhibit anti-inflammatory actions, yet the importance of direct immune cell GLP-1R signaling remains uncertain. Although T cells respond to GLP-1, lo...
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Aron Jaffe @jaffeab.bsky.social · 07/09/2025
I inserted myself into a conversation at a bar about Covid and vaccines. Here’s what happened www.statnews.com/2025/09/06/c... via @statnews.com
statnews.com
I inserted myself into a conversation at a bar about Covid and vaccines. Here’s what happened
What happened when a public health scientist overheard four men sharing misinformation about Covid — and decided to talk to them about it.
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Aron Jaffe @jaffeab.bsky.social · 04/07/2025
www.nature.com/articles/d41...
nature.com
How we’re rebuilding the Weizmann Institute — and our hopes for a better future
Scientific research is at the heart of Israel’s success and has worldwide benefits. Our work will continue despite adversity.
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Aron Jaffe @jaffeab.bsky.social · 27/05/2025
When a therapeutic approach works, it's on us as a global community to figure out how to get it to ALL patients in need. Great piece by @jasonmast.bsky.social What Baby KJ means for the CRISPR gene editing industry www.statnews.com/2025/05/26/w... via @statnews.com
statnews.com
What Baby KJ means for the CRISPR gene editing industry
The custom-built gene editing treatment for 6-month-old KJ Muldoon could not have come at a more welcome or jarring time for CRISPR-powered biomedicine.
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Aron Jaffe @jaffeab.bsky.social · 20/05/2025
www.nytimes.com/2025/05/20/o...
nytimes.com
Opinion | Joe Biden Has a Chance to Do Something Astounding
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Aron Jaffe @jaffeab.bsky.social · 29/04/2025
FDA delays are bad in general, but for a small biotech they can be existential. Let’s hope this is an edge case. endpts.com/fda-delays-s...
endpts.com
FDA delays PDUFA date for small biotech, raising questions about impact of agency cuts
The fate of a small, privately-held biotech’s new drug has been delayed, in what appears to be a sign that broad cuts to the FDA by the Trump administration may ...
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Aron Jaffe @jaffeab.bsky.social · 15/04/2025
Congrats to Sek Kathiresan and the entire Verve Therapeutics team. Big day for the field. Bigger day for patients. www.globenewswire.com/news-release...
globenewswire.com
Verve Therapeutics Announces Positive Initial Data from the Heart-2 Phase 1b Clinical Trial of VERVE-102, an In Vivo Base Editing Medicine Targeting PCSK9
Single infusion of VERVE-102 led to dose-dependent decreases in blood PCSK9 and LDL-C, with mean reduction in LDL-C of 53% and a maximum reduction of 69%...
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Aron Jaffe @jaffeab.bsky.social · 06/04/2025
First game of the season with the boy. Never gets old.
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Reposted by Aron Jaffe
Endpoints News @endpts.com · 24/03/2025
Tempero Bio raises $70M for TMP-301, a daily pill in development for alcohol and cocaine use disorders. Phase 2 data expected in 2026. endpts.com/tempero-bio-...
endpts.com
Tempero Bio, led by ex-Novartis execs, gets $70M to reduce substance use disorders
A small Oakland, CA-based biotech hoping to take on the sprawling landscape of substance use disorders and addiction has reeled in $70 million. The drug development startup, named Tempero Bio ...
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Aron Jaffe @jaffeab.bsky.social · 10/03/2025
This is a big day for patients with AATD and a big win for genomic medicine. Congrats to the entire Beam Team @BeamTx! investors.beamtx.com/news-release...
investors.beamtx.com
Beam Therapeutics Announces Positive Initial Data for BEAM-302 in the Phase 1/2 Trial in Alpha-1 Antitrypsin Deficiency (AATD), Demonstrating First Ever Clinical Genetic Correction of a Disease-causin...
Single Dose of BEAM-302 Led to Durable, Dose-dependent Increases in Total and Functional Alpha-1 Antitrypsin (AAT), Production of Corrected M-AAT, and Decreases in Mutant Z-AAT in Circulation Across I...
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Aron Jaffe @jaffeab.bsky.social · 06/03/2025
This 💯
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Aron Jaffe @jaffeab.bsky.social · 27/02/2025
Completely preventable www.nytimes.com/2025/02/26/u...
nytimes.com
Unvaccinated Child Dies of Measles in Texas Outbreak
At least 124 cases have been reported since late January, mostly among children and teenagers who were unvaccinated or whose vaccination status was unknown.
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Aron Jaffe @jaffeab.bsky.social · 27/02/2025
Congratulations to Stefan Irion, Seth Ettenberg, and the entire Blue Rock team! BlueRock Therapeutics receives FDA Fast Track Designation for OpCT-001 for the treatment of primary photoreceptor diseases www.bluerocktx.com/bluerock-the...
bluerocktx.com
BlueRock Therapeutics receives FDA Fast Track Designation for OpCT-001 for the treatment of primary photoreceptor diseases  - BlueRock Therapeutics LP
The U.S. Food and Drug Administration (FDA) has granted Fast Track designation for OpCT-001, an investigational induced pluripotent stem cell (iPSC)-derived cell therapy for the treatment of primary p...
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Aron Jaffe @jaffeab.bsky.social · 26/02/2025
www.sandiegouniontribune.com/2025/02/25/o...
sandiegouniontribune.com
Opinion: Science funding cuts are based on flawed logic. Here’s the truth.
Earlier this month, the National Institutes of Health issued supplemental guidance indicating it would immediately impose a 15% cap on indirect costs for research grants, an unprecedented and abrup…
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Reposted by Aron Jaffe
Lisa Jarvis @lisamjarvis.bsky.social · 16/02/2025
The flu, meanwhile, has been going from mild to wild in recent weeks.
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Eric Topol @erictopol.bsky.social · 10/02/2025
Most genome editing work to date has been DNA based. A new paper out today assessed a single dose of epigenetic editing (thru PCSK9) for marked (~70%) and durable reduction of LDL cholesterol [in non-human primates] www.nature.com/articles/s41...
nature.com
A potent epigenetic editor targeting human PCSK9 for durable reduction of low-density lipoprotein cholesterol levels - Nature Medicine
Epigenetic editing of PCSK9 in the liver, designed to induce DNA methylation and silence gene expression, achieved long-lasting reductions in LDL cholesterol levels in both transgenic mice expressing ...
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Aron Jaffe @jaffeab.bsky.social · 10/02/2025
Our work describing the development of a potent epigenetic editor targeting human #PCSK9 for durable reduction of LDL-C is out in @naturemedicine.bsky.social today! Cc: @chromamedicine @nchromabio 1/9 www.nature.com/articles/s41...
nature.com
A potent epigenetic editor targeting human PCSK9 for durable reduction of low-density lipoprotein cholesterol levels - Nature Medicine
Epigenetic editing of PCSK9 in the liver, designed to induce DNA methylation and silence gene expression, achieved long-lasting reductions in LDL cholesterol levels in both transgenic mice expressing ...
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Aron Jaffe @jaffeab.bsky.social · 01/02/2025
As usual, @lisamjarvis.bsky.social absolutely nailing it.
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Aron Jaffe @jaffeab.bsky.social · 30/01/2025
iPSC-derived cardiomyocytes + stromal cells = engineered heart muscle Science is truly amazing www.nature.com/articles/s41...
nature.com
Engineered heart muscle allografts for heart repair in primates and humans - Nature
Epicardial engineered heart muscle allografts from induced pluripotent stem cell-derived cardiomyocytes can safely and effectively remuscularize chronically failing hearts in rhesus macaques, leading ...
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Aron Jaffe @jaffeab.bsky.social · 29/01/2025
💯👇🏼 ‘These founders have this idea, and for $10 million we can literally go from what those founders had to a development candidate…. It’s extraordinarily exciting’ www.statnews.com/2025/01/29/c...
statnews.com
Biotech accelerator Curie.Bio raises $340 million for a new seed fund
Curie.Bio, the biotech accelerator and investment firm, has raised another $340 million to invest in startups.
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Aron Jaffe @jaffeab.bsky.social · 14/01/2025
Welcome to curie.bio Ben! Excited to be working together! endpts.com/after-gsk-de...
endpts.com
Exclusive: Day after GSK buyout, IDRx chair takes new investing role at Curie.Bio
SAN FRANCISCO — Ben Auspitz, a veteran biotech investor and repeat entrepreneur, is reuniting with longtime collaborator Alexis Borisy and his
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Aron Jaffe @jaffeab.bsky.social · 13/01/2025
Congrats to Seth Ettenberg, Stefan Irion, and the entire Blue Rock team. #Parkinsons patients are waiting. www.bayer.com/media/en-us/...
bayer.com
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Aron Jaffe @jaffeab.bsky.social · 13/01/2025
BIG SPLASH to start #JPMWeek! #JPM25 www.businesswire.com/news/home/20...
businesswire.com
Johnson & Johnson Strengthens Neuroscience Leadership with Acquisition of Intra-Cellular Therapies, Inc.
Johnson & Johnson (NYSE: JNJ) and Intra-Cellular Therapies, Inc. (Nasdaq: ITCI) announced today that they have entered into a definitive agreement
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Aron Jaffe @jaffeab.bsky.social · 13/01/2025
Nice start to the week. Congrats to the IDRx team. #JPM25 www.businesswire.com/news/home/20...
businesswire.com
GSK Enters Agreement to Acquire IDRx, Inc.
GSK plc (LSE/NYSE: GSK) and IDRx, Inc. (IDRx) today announced that they have entered into an agreement under which GSK will acquire IDRx, a Boston-bas
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Aron Jaffe @jaffeab.bsky.social · 12/01/2025
Safe travels to friends and colleagues heading to #JPM25
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Aron Jaffe @jaffeab.bsky.social · 07/01/2025
Big day for patients with #T1D ir.sana.com/news-release...
ir.sana.com
Sana Biotechnology Announces Positive Clinical Results from Type 1 Diabetes Study of Islet Cell Transplantation Without Immunosuppression | Sana Biotechnology, Inc
First-in-Human Study Provides Evidence that Sana’s Hypoimmune (HIP) Technology Enables Transplanted Islet Cells to Avoid Immune Rejection and Produce Insulin Without Immunosuppression Results Demonstr...
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Aron Jaffe @jaffeab.bsky.social · 03/01/2025
That feeling when you hear your wife singing 'Roy Kent! Roy Kent! He's here! He's there! He's every f*ckin' where!' and realize she's binge watching Ted Lasso cc: @brendanhunting.bsky.social
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Aron Jaffe @jaffeab.bsky.social · 29/12/2024
www.nature.com/articles/d41...
nature.com
Stem cells head to the clinic: treatments for cancer, diabetes and Parkinson’s disease could soon be here
More than 100 clinical trials put stem cells for regenerative medicine to the test. It’s a turning point for a field beset with ethical and political controversy.
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Aron Jaffe @jaffeab.bsky.social · 17/12/2024
Chicago’s biotech scene is growing up. What’s fueling it? - endpts.com/chicagos-bio...
endpts.com
Chicago’s biotech scene is growing up. What’s fueling it?
Over the years, a handful of cities have tried catching up to the flourishing biotech hubs in Boston or the San Francisco Bay Area. Chicago, the third-largest city in the US, is putting together its b...
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Aron Jaffe @jaffeab.bsky.social · 15/12/2024
The number also changes (dramatically) depending on whether you include #microproteins Cc: @thomasmartinez.bsky.social
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Aron Jaffe @jaffeab.bsky.social · 14/12/2024
Week 1 at curie.bio in the books Amazing breadth of science Exciting therapeutic approaches to treat disease Dynamic, diverse, highly motivated team This is going to be a ton of fun
curie.bio
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American Society for Cell Biology @ascbiology.bsky.social · 14/12/2024
We would like to thank all our volunteers--Council Members, Committee Chairs, and Committee members for all they do for ASCB and cell science! #cellbio2024 #cellbiology
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Aron Jaffe @jaffeab.bsky.social · 11/12/2024
Like drug discovery, a company's journey is rarely, if ever, a straight line. Best of luck to former @chromamedicine colleagues in this next phase of the journey to bring #epigeneticediting medicines to patients as @nchromabio www.statnews.com/2024/12/11/c...
statnews.com
Gene-editing field sees another merger, this time between Chroma Medicine and Nvelop Therapeutics
In industry parlance, the deal joins a “delivery” company with a “cargo” company — fusing the two key pieces needed to build a genetic medicine.
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Aron Jaffe @jaffeab.bsky.social · 09/12/2024
Excited to continue my passion for translating cutting edge technologies & biological insights into new therapeutic approaches to disease as part of the team at curie.bio starting TODAY! Feels like the first day of school, except I don’t have to bring my own snacks...
curie.bio
Curie.Bio
Curie.Bio is a new model for venture capital in biotech. We are focused on a singular mission – helping founders launch therapeutics companies that go on to raise an awesome next round of financing.
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Aron Jaffe @jaffeab.bsky.social · 06/12/2024
I love @helenbranswell.bsky.social's reporting, but I have to say I'd be happy not to read any of her stories for a few years... www.statnews.com/2024/12/05/h...
statnews.com
Single mutation in H5N1 bird flu virus may make it more infectious to humans, study finds
Study published in Science says a single hemagglutinin mutation, similar to one seen in a Canadian case, could make H5N1 better suited to infect people.
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Aron Jaffe @jaffeab.bsky.social · 04/12/2024
Exceptionally cool story from @michelcayouette.bsky.social & colleagues - a polarity/developmental process triggered by light?!?!
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Aron Jaffe @jaffeab.bsky.social · 03/12/2024
Boston and San Francisco may get the lion's share of splashy #biotech news, but value comes from everywhere. Great to see the innovation in the Chicago biotech seen being recognized and making an impact. #mykindoftown endpts.com/roche-teams-...
endpts.com
Roche teams up with Chicago autoimmune biotech COUR Pharmaceuticals
Roche's Genentech will work with a Chicago-area biotech to create nanoparticle treatments for an undisclosed autoimmune disease, the companies said Tuesday morning. Genentech is paying $40 million in ...
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Aron Jaffe @jaffeab.bsky.social · 02/12/2024
www.statnews.com/2024/12/02/r...
statnews.com
'Significant talent shortage' threatens the rise of radiopharmaceuticals
There's growing interest in radiopharmaceuticals. But a "significant talent shortage" may threaten the field's rise.
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Aron Jaffe @jaffeab.bsky.social · 01/12/2024
Another beautifully-written piece by @doctorveera.bsky.social 'One of the biggest mysteries of human genome... is the biological mechanism through which noncoding variants influence disease-risks and trait variations.' 💯 www.gwasstories.com/p/de-novo-en...
gwasstories.com
De novo enhancer creation by a noncoding mutation
Genetic investigation of a cardiac arrhythmia reveals a new noncoding Mendelian disease mechanism
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Aron Jaffe @jaffeab.bsky.social · 30/11/2024
Earlier this month marked the end of my nearly 3 years as Head of Research @chromamedicine. What an amazing time! x.com/jaffeab/stat... (thread)
x.com
x.com
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