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Mads Israelsen

@israelsenm.bsky.social
213 followers 114 following 10 posts

MD PhD. Hepatology researcher. Odense Liver Research Center. EASL YI Task Force.

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Reposted by Mads Israelsen
JAMA @jama.com · 06/07/2026
ALD develops with chronic daily #alcohol consumption (>20 g/d for women, >30 g/d for men) and encompasses reversible #steatosis, #steatohepatitis, #fibrosis, #cirrhosis, and #hepatocellular #carcinoma. 🔗 ja.ma/4eVgvZK
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Reposted by Mads Israelsen
JAMA @jama.com · 06/07/2026
📝 JAMA Review: #AlcoholRelatedLiverDisease is the leading cause of #liver-related #mortality and the most common indication for liver #transplant in Europe and the US, with mortality rates rising over the past two decades. 🔗 ja.ma/4eVgvZK
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Marisa Isabell Keller @maelschermarisa.bsky.social · 01/06/2026
Our work exploring host-microbial co-metabolism of bile acids in patients with alcohol-related liver disease (ALD) has been published in the JHEP Reports: www.sciencedirect.com/science/arti... 🪐 A big thank you to everyone involved, to the GALAXY and MicrobLiver consortia who made this possible! 🙌
sciencedirect.com
Alcohol-related liver disease disrupts bile acid homeostasis and gut microbial bile acid metabolism
Alcohol overuse disrupts liver function and alters gut microbial communities, with alcohol-related liver disease (ALD) causing half of all liver-relat…
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MICROB-PREDICT @microb-predict.bsky.social · 28/05/2026
This morning, with the talk 'From biomarkers to bedside: Stratified risk assessment in ALD/MetALD and mobile health to close care gaps', @israelsenm.bsky.social (Odense University Hospital) contributed to the session The Road Ahead [...] at #EASLCongress #EASL2026 #MetALD
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Reposted by Mads Israelsen
Eric Topol @erictopol.bsky.social · 30/04/2026
First randomized trial to show Ozempic reduces alcohol consumption in people seeking treatment for alcohol use disorder. Placebo-controlled, double-blind. Participants with BMI >30 kg/m2. thelancet.com/journals/lan...
thelancet.com
Once-weekly semaglutide versus placebo in patients with alcohol use disorder and comorbid obesity: a randomised, double-blind, placebo-controlled trial
Semaglutide showed robust therapeutic effects in treatment-seeking participants with obesity and alcohol use disorder and this trial supports previous preclinical and clinical findings suggesting GLP-...
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Reposted by Mads Israelsen
The Lancet Gastroenterology & Hepatology @lancetgastrohep.bsky.social · 11/09/2025
New research - Phosphatidylethanol and self-reported alcohol intake to subclassify in individuals at risk of steatotic liver disease: an analysis of data from a prospective cohort study www.thelancet.com/journals/lan... #LiverSky #MedSky @aleksanderkrag.bsky.social @israelsenm.bsky.social
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Mads Israelsen @israelsenm.bsky.social · 11/09/2025
How should we use PEth in SLD care? 🩸🍺 Our study in @lancetgastrohep.bsky.social (n≈3,000) shows: 🔍 39% of MASLD → MetALD/ALD with PEth ⨻ Triangulating self-report + AUDIT-C + PEth = better classification ⚖️ But 40% get no added value → use selectively www.sciencedirect.com/science/arti...
sciencedirect.com
Phosphatidylethanol and self-reported alcohol intake to subclassify in individuals at risk of steatotic liver disease: an analysis of data from a prospective cohort study
Phosphatidylethanol is a direct biomarker of alcohol consumption within the past 1–4 weeks, making it a potential tool in the subclassification of pat…
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Reposted by Mads Israelsen
The Lancet Gastroenterology & Hepatology @lancetgastrohep.bsky.social · 16/07/2025
New Review - Screening for advanced steatotic liver disease www.thelancet.com/journals/lan... #LiverSky #MedSky @aleksanderkrag.bsky.social
thelancet.com
Screening for advanced steatotic liver disease
Steatotic liver disease often progresses asymptomatically, with the risk of advancing to cirrhosis and liver cancer. Early detection of advanced liver disease through screening presents an opportunity...
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Reposted by Mads Israelsen
JHEP Reports @jhep-reports.bsky.social · 24/06/2025
🎉Our new Impact Factor is 7.5! We are firmly among the top journals in hepatology👏 Thank you to our authors, reviewers & readers!🙏 #LiverSky @easlnews.bsky.social
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Reposted by Mads Israelsen
The Lancet Gastroenterology & Hepatology @lancetgastrohep.bsky.social · 06/06/2025
New Editorial — Alcohol and health: time for Europe to sober up www.thelancet.com/journals/lan... #alcohol #liversky #medsky
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Journal of Hepatology @jhepatology.bsky.social · 18/06/2025
📢Our new Impact Factor is 33.0🎉 🥇Ranking number 1 in the Hepatology field🥇 👏Thanks to the Editorial Team, untiring peer reviewers & very innovative authors❕ #LiverSky @easlnews.bsky.social
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Reposted by Mads Israelsen
A-TANGO Project @a-tango.bsky.social · 12/05/2025
✅ How to reach a #consensus in science 🧬: Clinic director Frank Tacke (Charité) trains future #hepatology leaders on the #DelphiMethod, a reliable forecasting method using multiple rounds of questionnaires for an expert panel to reach a mutual agreement. 🗓️ What a fun #workshop at #EASLCongress 2025
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MICROB-PREDICT @microb-predict.bsky.social · 10/05/2025
🧪 Mads Israelsen (Odense Universitetshospital – Svendborg Sygehus) leads together with Alberto Zanetto the YI #Workshop on How to prepare a #Clinical #Practice #Guideline in Hepatology, offering valuable insights for young investigators. 📅 Presented at the #EASLCongress | #EASL2025
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Reposted by Mads Israelsen
MICROB-PREDICT @microb-predict.bsky.social · 10/05/2025
One last time #LIVE from the #EASLStudio: Tot Ziens Amsterdam, Hola Barcelona! 👋 As #EASL2025 draws to a close, Debbie Shawcross and Aleksander Krag reflect on the highlights from Amsterdam and set the stage for #EASL2026 in Barcelona. Thank you for an inspiring #EASLCongress - see you next year!
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Reposted by Mads Israelsen
MICROB-PREDICT @microb-predict.bsky.social · 08/05/2025
🤩 Full house at General Session 1 today 🥳 Abstract Session “General #Hepatology”, chaired by Aleksander Krag from Odense University Hospital in Denmark 🇩🇰, featuring a broad range of cutting-edge #LiverResearch 🔬. 📅 Presented at #EASLCongress | #EASL2025 🕥 10:30 – 12:30 h @easlnews.bsky.social
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Reposted by Mads Israelsen
MICROB-PREDICT @microb-predict.bsky.social · 08/05/2025
📚 Learning from the best at the EASL Congress: Maja Thiele (OUH) discusses Alcohol-related liver disease as part of The JHEP Reports Symposium: Keys to get your manuscript accepted. 💡 #EASL2025
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Reposted by Mads Israelsen
MICROB-PREDICT @microb-predict.bsky.social · 08/05/2025
🐭 Blockage of microfibrillar-associated protein 4 (MFAP4) decreases liver fibrosis in two murine models of steatotic liver disease #POSTER THU-058-YI by Maximilian Brol (UM) presents preclinical data showing that blocking MFAP4 reduces #liver #fibrosis in two murine models. #EASL2025
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NEJM.org @nejm.org · 30/04/2025
In this interim analysis of a phase 3 trial involving 800 patients with metabolic dysfunction–associated steatohepatitis, once-weekly semaglutide improved liver histologic results at 72 weeks. Full ESSENCE trial results: nej.md/3EVFAFM #MedSky #EndoSky #GastroSky
The figure shows the percentage of patients with fibrosis stage 2 or 3 who had resolution of steatohepatitis with no worsening of liver fibrosis (Panel A) and reduction in liver fibrosis with no worsening of steatohepatitis (Panel B) after 72 weeks, with the estimated difference expressed in percentage points.
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Reposted by Mads Israelsen
Hannes Hagström @liverepi.bsky.social · 13/04/2025
🚨New paper from us in Journal of Hepatology - Using PEth values on >50,000 persons to predict outcomes. www.sciencedirect.com/science/arti...
sciencedirect.com
Phosphatidylethanol levels distinguish steatotic liver disease subgroups and are associated with risk of major liver outcomes
Phosphatidylethanol (PEth) is an ethanol metabolite used as a specific biomarker for recent alcohol consumption. We aimed to determine the proportion …
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Reposted by Mads Israelsen
Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 31/03/2025
APRIL ISSUE | Our Featured PERSPECTIVE is on "The steatotic liver disease burden paradox: unravelling the key role of alcohol" www.nature.com/articles/s41... #Liversky
Fig. 4: The bidirectional linking of factors that predispose to steatotic liver disease.
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Reposted by Mads Israelsen
Mads Israelsen @israelsenm.bsky.social · 08/04/2025
@aga-cgh.bsky.social @majathiele.bsky.social @aleksanderkrag.bsky.social #Thorhauge
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Mads Israelsen @israelsenm.bsky.social · 08/04/2025
Our newdata show 38% of individuals with SLD are reclassified over 2 years ‼️ Over 60% with MetALD/ALD and 38% with MASLD change subclass. This highlights that alcohol use and metabolic risk need regular reassessment, incl. for clinical trial eligibility 🧐 Link: www.cghjournal.org/article/S154...
cghjournal.org
Steatotic liver disease classification is dynamic, affecting clinical trial eligibility and subclass-specific treatments
Steatotic liver disease (SLD) includes the subclasses metabolic-dysfunction associated steatotic liver disease (MASLD), metabolic and alcohol-related liver disease (MetALD) and alcohol-related liver d...
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Reposted by Mads Israelsen
Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 31/03/2025
#liversky #gastrosky #oncsky
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Mads Israelsen @israelsenm.bsky.social · 01/04/2025
MASLD vs MetALD/ALD is often reduced to ‘alcohol or not’. But alcohol use is not binary—and SLD is a dynamic spectrum where alcohol plays a significant role across phenotypes. Time to rethink the simplistic divide 🧐 @aleksanderkrag.bsky.social @natrevgastrohep.bsky.social
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Reposted by Mads Israelsen
EASL @easlnews.bsky.social · 17/03/2025
Have you secured your spot for #EASLCongress 2025 on 7-10 May? 🌍Join us in Amsterdam or online to transform liver care worldwide! easlcongress.eu/2025-registr... 📜The deadline to submit your late-breaker abstract is TODAY, 17 March! easlcongress.eu/2025-abstrac...
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Reposted by Mads Israelsen
The Lancet Gastroenterology & Hepatology @lancetgastrohep.bsky.social · 12/03/2025
New Review - Neurath, Artis, Becker - The intestinal barrier: a pivotal role in health, inflammation, and cancer www.thelancet.com/journals/lan... #GastroSky #MedSky
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Reposted by Mads Israelsen
Elliot Tapper @ebtapper.bsky.social · 09/03/2025
AASLD is here @aasldnews.bsky.social @aasldfoundation.bsky.social #liversky
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Reposted by Mads Israelsen
Bork Group at EMBL Heidelberg @borklab.bsky.social · 26/02/2025
We're once again hosting the Human #Microbiome conference at @embl.org, organized by Ami Bhatt, Nicola Segata, Mani Arumugam and Peer Bork! We always have a great lineup of speakers, so register now and think about an abstract to submit (abstract submission deadline in June)
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Reposted by Mads Israelsen
Journal of Hepatology @jhepatology.bsky.social · 17/01/2025
Journal of Hepatology is now on Bluesky 🌤️ 📢Check our January issue❗️ 🎉Celebrating 40 years of discovery in #liverresearch🎉 🙏Thank you to our authors, editors, reviewers, & readers for supporting us on this incredible journey Full issue here👉https://bit.ly/42en2Kp #LiverSky @easlnews.bsky.social
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Reposted by Mads Israelsen
EASL @easlnews.bsky.social · 17/02/2025
🚀 Join #EASLCongress 2025 (7–10 May, Amsterdam & online) for cutting-edge hepatology, expert insights & hands-on training! Register Now 👉 easlcongress.eu/2025-registr... Scientific Programme 👉https://www.easlcongress.eu/2025-scientific-programme/
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MICROB-PREDICT @microb-predict.bsky.social · 17/02/2025
🚀 7th GA #Meeting in Cologne, Germany from 27-29 January 2025! A huge thank you to everyone for sharing their latest results and project updates! 👏 And of course, we wrapped it up with some after-work fun, exploring Cologne with a @sciencerallye.bsky.social! 🏙️ ⛲
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Annalisa Berzigotti @docberza.bsky.social · 14/02/2025
Happy to share a new review article in JHep Reports written by @mattiasmandorfer.bsky.social @juanabraldes.bsky.social and myself - take a look! www.jhep-reports.eu/article/S258...
jhep-reports.eu
Non-invasive assessment of portal hypertension: Liver stiffness and beyond
Portal hypertension (PH) leads to life-threatening clinical manifestations such as bleeding from gastro-oesophageal varices, ascites and its complications, and portosystemic encephalopathy. It can dev...
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Reposted by Mads Israelsen
Peter Jepsen @peterjepsen.bsky.social · 14/02/2025
JHEP Reports has published our update cirrhosis epidemiology in Denmark: www.sciencedirect.com/science/arti... Our population of cirrhosis patients is changing: They're older now than they used to be, and fewer have ALD. The incidence of ALD is decreasing in Denmark, unlike in so many other places.
sciencedirect.com
Cirrhosis epidemiology in Denmark 1998–2022 and 2030 forecast
Cirrhosis incidence due to alcohol-related liver disease (ALD) is decreasing in Denmark, while the obesity incidence is increasing, expectably driving…
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Reposted by Mads Israelsen
MICROB-PREDICT @microb-predict.bsky.social · 14/02/2025
Feeling butterflies in your tummy? 🦋 It’s not just Valentine’s Day - it’s the excitement of MICROB-PREDICT joining #Bluesky! 🙌 Let’s connect! 🌐 @easlnews.bsky.social @decision4liver.bsky.social @amelischwalber.bsky.social @concentris.bsky.social @a-tango.bsky.social @ninadonner.bsky.social
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Elliot Tapper @ebtapper.bsky.social · 06/02/2025
BREAKING: rifaximin and simvastatin did not help people with decompensated cirrhosis Congratulations to Elisa Pose And congrats to @jama.com for getting this paper #liversky t.co/BuPL0mURhl
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Ramon Bataller @rbataller.bsky.social · 04/02/2025
t.co/K58c1IzF64
t.co
https://www.jhep-reports.eu/article/S2589-5559(24)00254-4/fulltext
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Reposted by Mads Israelsen
Rob Brierley @robbrierley.bsky.social · 03/02/2025
The Lancet Gastroenterology & Hepatology is now on Bluesky! bsky.app/profile/lanc... Follow us! #GastroSky #LiverSky #MedSky
bsky.app
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Mads Israelsen @israelsenm.bsky.social · 02/02/2025
@rbataller.bsky.social
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Reposted by Mads Israelsen
aleksanderkrag.bsky.social @aleksanderkrag.bsky.social · 31/01/2025
#EASL Studio season 8 starts next week, we will discuss Steatotic Liver Disease - how the current breakthroughs will transform clinical practice. Want to stay updated join us.! easl.eu/easl-studio-...
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Reposted by Mads Israelsen
EASL @easlnews.bsky.social · 29/01/2025
The authors of today’s #readoftheweek📚 discuss the functional genetic study of protein-altering variants, and how it provides insights on the association between loss of TM6SF2 function and #SLD. Read here this JHEP Reports article: www.jhep-reports.eu/article/S258... #LiverSky
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Ramon Bataller @rbataller.bsky.social · 29/01/2025
We tend to think that all decompensated cirrhosis are the same. During the 12 years that I practiced in the USA, I learnt that MASLD cirrhosis is different. See below the 10 more common specific medical issues of MASLD CIRRHOSIS that I found:
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Mads Israelsen @israelsenm.bsky.social · 29/01/2025
AlbTrial Update 🏥 70 out of 240 included But what is AlbTrial? AlbTrial is one of the most ambitious RCTs in the field of decompensated cirrhosis. 🔗 bmjopen.bmj.com/content/bmjo... 🧵below Annual General Assembly in MicrobPredict #liversky #cirrhosis
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Mads Israelsen @israelsenm.bsky.social · 28/01/2025
@suguru-nishijima.bsky.social @borklab.bsky.social @biocs.bsky.social @evelinastn.bsky.social @majathiele.bsky.social @aleksanderkrag.bsky.social
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Reposted by Mads Israelsen
Elliot Tapper @ebtapper.bsky.social · 27/01/2025
Efruxifermin reversing some cirrhosis in phase 2b ir.akerotx.com/news-release...
ir.akerotx.com
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Reposted by Mads Israelsen
Elliot Tapper @ebtapper.bsky.social · 25/01/2025
There has been a recent influx to #gisky and #liversky To sustain this, you need to be active. If you were a lurker, no we need your pearls, papers, and pets. Post. Use the hashtags. Build.
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Reposted by Mads Israelsen
Rob Brierley @robbrierley.bsky.social · 22/01/2025
What impact do reporting discrepancies in alcohol intake have on the estimated prevalence of MetALD and alcohol-related liver disease? @aleksanderkrag.bsky.social and colleagues discuss… www.thelancet.com/journals/lan... #GastroSky #MedSky
thelancet.com
Reporting discrepancy of alcohol intake affecting estimated prevalence of MetALD and ALD
For several decades, the prevalence of steatotic liver disease (SLD) has been steadily increasing.1 Alterations in hepatic lipid metabolism, causing steatosis, can result from several factors predomin...
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Reposted by Mads Israelsen
Rui Castro @ruicastrohd.bsky.social · 24/01/2025
Young Investigator Poster Tour @easlnews.bsky.social #SLDSummit Huge attendance and interest! 👏🏼 @tom-marjot.bsky.social @madsisraelsen.bsky.social
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