This randomized clinical trial evaluates whether adults receiving measurement-based care vs standard care for major depressive disorder have faster response and remission times.

A large international panel of experts reach consensus on a new standard for reporting settings in psychedelic trials, identifying 30 key non-pharmacological factors to strengthen the rigor of psyched...

This cohort study examines how maternal warmth at 3 years of age shapes adolescent social safety schemas at 14 years of age and physical and mental health at 17 years of age.

Neuropsychopharmacology - Associations between structural brain measures and cognitive function in bipolar disorder: a systematic review and meta-analysis

This narrative review describes clinical trials of psychedelic or MDMA therapy and reports from the investigators on the use of modifications to informed consent in these studies.

To determine the relationships between psilocybin dose, psychedelic experiences, and therapeutic outcome in treatment-resistant depression.For treatme…

Although studies of psychedelic-assisted psychotherapy are accumulating, there is no consensus regarding best practice of the psychotherapeutic component. In this systematic review, we summarised the quality of reporting on psychological interventions in research about psychedelic treatments. The design followed PRISMA guidelines and was preregistered in PROSPERO (CRD42022319221). We searched MEDLINE, PsycINFO, and Embase for original studies on psychedelic-assisted psychotherapy and included 45 studies assessing psilocybin, 3,4-methylenedioxymethamphetamine (MDMA), lysergic acid diethylamide (known as LSD), or ayahuasca, for the treatment of mental disorders.

The therapeutic benefits of psychedelics might be ascribed to their subjective effects, but methodological barriers limit interpretation of this association. In this Review, Yaden et al. balance the l...

Is there a formula for a competitive NIH grant application? The Serenity Prayer may provide one: "Grant me the serenity to accept the things I cann...

Early instruction that teaches young people how to recognise negative thought patterns and manage their mental health may help to avoid problems in later life I was about 16 when I had my first bout of depression, but 29 when I sought help and received a…