Reposted by @irlalab.bsky.socialWaggoner Lab @labwaggoner.bsky.social · 13/02/2026Reversing age-related thymic decline restores immunity and paves the way for healthy aging @irlalab.bsky.social www.science.org/doi/10.1126/... 021
Reposted by @irlalab.bsky.socialCentre d'Immunologie de Marseille Luminy @ciml.bsky.social · 02/04/2025Today, we had the pleasure of welcoming Dr. Jakub Abramson from the Weizmann Institute of Science, as part of the 2025 CIML seminar series. Jakub gave a great seminar: “From Thymic Mysteries to Sex hormones - HECking the sexual dimorphism of the immune response” Thanks Jakub for your visit! 011
Reposted by @irlalab.bsky.socialCentre d'Immunologie de Marseille Luminy @ciml.bsky.social · 11/02/2025Today, we celebrate International Women’s Day in Science. To honor this day, we've created seven portraits of ♀️ scientists at CIML. Each portrait reflects their unique journey and contributions. Stay tuned for their inspiring stories. #WomenInScience @inserm.fr @cnrs.bsky.social @univ-amu.fr 8203
Reposted by @irlalab.bsky.socialCentre d'Immunologie de Marseille Luminy @ciml.bsky.social · 11/02/2025 031
irlalab.bsky.social @irlalab.bsky.social · 25/01/2025Having a great time with the team ! #immunology #CIML 010
irlalab.bsky.social @irlalab.bsky.social · 06/12/2024Thanks to @agencerecherche.bsky.social (ANRRANKLThym), Bristol-Myers Squibb Foundation and Fondation ARC for supporting our project ! 010
irlalab.bsky.social @irlalab.bsky.social · 06/12/2024We provide the proof-of-concept that RANKL stimulates human endothelial and epithelial cells using thymic organo-cultures, providing an exciting new therapeutic approach in the arsenal of regenerative medicine to rejuvenate the immune system. 100
irlalab.bsky.social @irlalab.bsky.social · 06/12/2024This increased production leads to peripheral T-cell renewal and improves T-cell-mediated anti-tumor and vaccine responses in aged mice. 100
irlalab.bsky.social @irlalab.bsky.social · 06/12/2024RANKL treatment in aged mice restores thymic architecture as well as cellularity and functional properties of endothelial and epithelial cells. This boosted T-cell production in the aged thymus. 100
irlalab.bsky.social @irlalab.bsky.social · 06/12/2024The RANK-RANKL axis in the thymus is altered during aging. In addition to thymic epithelial cells, endothelial cells depend on RANK signaling for their cellularity and functional maturation. 100
irlalab.bsky.social @irlalab.bsky.social · 06/12/2024Excited to share our 1st post ! Thrilled to share our latest research in Science Translational Medicine ! @science.org We show that RANKL administration reverses thymic involution and rejuvenates T cell immunity. @ciml.bsky.social #Aging #Thymus #Tcells #Immunology #Involution #Rejuvenationscience.orgRANKL treatment restores thymic function and improves T cell–mediated immune responses in aged miceRANK ligand administration reversed age-dependent thymic involution and rejuvenated T cell immunity in mice. 1448
