Three-photon in vivo imaging provides access to medial prefrontal cortex, hippocampus and spinal cord in mice at up to 1.7 mm depth of neurons, dendrites, spines, astrocytes and microglia.

Neocortical circuits use synaptic and intrinsic forms of homeostatic plasticity to stabilize key features of network activity, but whether these di...

US science funder also plans to screen grant applications for compliance with ‘agency priorities’.

Join EURAXESS North America and MSKCC us for a webinar on the bottom-up grants available from the European Research Council, the premier European funding organization for excellent frontier research.

Stress-induced depression-like behaviors are driven by a dynamic recurrent network involving neurons and astrocytes in the lateral habenula and norepinephrine release from neurons in the locus coeruleus in freely moving mice.

GABA is the primary inhibitory neurotransmitter in the central nervous system. Using two-photon GABA imaging, Matsumoto et al. reveal over 40 GABA neuron types in the mouse retina, each uniquely filte...

Yellow fluorescent proteins (YFPs) photobleach rapidly, restricting microscopy experiments. Here, the authors report mGold2s and mGold2t, YFPs that extend imaging durations up to 25 times longer than ...

A pyramidal cell type and the 5-HT2A receptor in the medial frontal cortex have essential roles in psilocybin’s long-term drug action.

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Han et al. used snRNA-seq and Stereo-seq to generate a detailed mouse brain atlas with over 4 million spatially resolved cells and 29,655 genes. Their findings include region- enriched cell clusters and genes, spatiotemporal dynamics of transcription factor regulons, and a gene-based parcellation framework, providing a comprehensive resource for brain architecture.

Lucantonio et al. highlight a fundamental role for synaptic plasticity within the nucleus accumbens D1-medium spiny neurons (NAc D1-MSNs) in driving the anti-anhedonic effects of ketamine. They demonstrate that these effects are driven by restoration of…

The subunit acts as a “volume control” on signaling that shapes the density of dendritic spines, the new work suggests.