iiinova — where your digital self keeps evolving

👏 A big thanks to Élodie Monsellier @emonsellier.bsky.social and the team for their collaboration in bringing this integration to IntAct! #IntActEBI #PPI #NetworkBiology

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🔬✨ New in 𝐈𝐧𝐭𝐀𝐜𝐭! Quantitative fragmentomics data (Nat Commun 2022) now integrated into IntAct - bringing high-quality, quantitative protein-protein interactions to the database.

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👏 A big thanks to Élodie Monsellier @emonsellier.bsky.social and the team for their collaboration in bringing this integration to IntAct! #IntActEBI #PPI #NetworkBiology

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🔬✨ New in 𝐈𝐧𝐭𝐀𝐜𝐭! 𝐐𝐮𝐚𝐧𝐭𝐢𝐭𝐚𝐭𝐢𝐯𝐞 𝐟𝐫𝐚𝐠𝐦𝐞𝐧𝐭𝐨𝐦𝐢𝐜𝐬 𝐝𝐚𝐭𝐚 (Nat Commun 2022) now integrated into IntAct - bringing high-quality, quantitative protein-protein interactions to the database.

IntAct @intact-ebi.bsky.social · 28/01/2026

IntAct release 252 is out! 1,787,152 binary interactions from 23,889 manually curated publications www.ebi.ac.uk/intact/about... (in sync with UniProt release 2025_04)

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IntAct @intact-ebi.bsky.social · 05/01/2026

👏 Huge thanks to UniProt for integrating the isoform information! 🤝 This was a joint curation effort by IntAct and UniProt, and a great example of collaborative science. Here’s to an exciting year ahead! 🚀🧬 tinyurl.com/N-terminal-p... #EMBLEBI #IntActEBI #UniProt #Proteoforms

IntAct @intact-ebi.bsky.social · 05/01/2026

🎉✨ Happy 2026! ✨🎉 We’re excited to kick off the year by sharing the integration of the work “N-terminal proteoforms may engage in different protein complexes” from the Kris Gevaert lab (VIB, Ghent, Belgium) 🎓🔬

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IntAct @intact-ebi.bsky.social · 24/11/2025

Registration is free but essential: tinyurl.com/4v3jf4e9 Speakers: Susie H. and Eliot Ragueneau #Bioinformatics #IntAct #Modelling #BiologicalNetworks #Cytoscape

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IntAct @intact-ebi.bsky.social · 24/11/2025

Would you like to learn more about molecular interactions and how to explore them across organisms? Join us next week for an introductory webinar where we will walk through the IntAct Portal's approach to molecular network modelling and show how this is implemented within the IntAct Cytoscape app.

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EMBL-EBI @ebi.embl.org · 25/11/2025

From a farm in the north of England to the frontiers of bioinformatics, our Group Leader Sandra Orchard reflects on a career building the data foundations of modern biology: “AI is showing how vital data curation really is.” www.ebi.ac.uk/about/news/p... 🖥️🧬

ebi.ac.uk

Sandra Orchard: what I’ve learned

EMBL-EBI Team Leader Sandra Orchard reflects on a life in protein science, UniProt data curation, and championing open data standards.

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EMBL-EBI @ebi.embl.org · 25/11/2025

Upon her retirement from EMBL-EBI, we thank Sandra for her dedication and foundational work on important open data resources including: UniProt Complex Portal @complexportal.bsky.social Gene Ontology @geneontology.bsky.social IntAct @intact-ebi.bsky.social InterPro @interprodb.bsky.social

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IntAct @intact-ebi.bsky.social · 24/11/2025

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IntAct @intact-ebi.bsky.social · 05/11/2025

🧫 Explore the curated dataset in IntAct ➡️ tinyurl.com/candidalysin 🎨IntAct Cytoscape visualisation: Candida albicans ECE1 peptides (orange) and their human protein targets (blue) #IntActEBI #Interactome #EMBL

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IntAct @intact-ebi.bsky.social · 05/11/2025

✨🧬New on IntAct! ✨ Interaction data from the study 📖“Global fungal–host interactome mapping identifies host targets of candidalysin” - Shanghai Jiao Tong University, Tongji University, and the Chinese Academy of Sciences. 🎉

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ComplexPortal @complexportal.bsky.social · 19/10/2025

Let’s make your science more FAIR - Findable, Accessible, Interoperable, and Reusable. #Biocuration #FromBenchToDatabase #FAIRdata #ProteinInteractions #EMBL-EBI #IntAct-EBI #OpenScience #UniProt #DataMatters

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ComplexPortal @complexportal.bsky.social · 19/10/2025

📥 Submit your data here: 🔹 IntAct: tinyurl.com/zzrcx742

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ComplexPortal @complexportal.bsky.social · 19/10/2025

Want your PPI or structural data to make an impact? ✅ Use Identifierss ✅ Include structured tables (e.g. Niri et al. 2021 - PMID: 34197713) ✅ Submit to EMBL-EBI's data resources - IntAct 👉 See Niri’s dataset in IntAct: tinyurl.com/yp8ddheh

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ComplexPortal @complexportal.bsky.social · 19/10/2025

Don’t just publish - be found! 🔍 I didn’t realize how vital biocuration was until I became a curator. A well-curated dataset doesn’t just sit in a paper - it lives on in databases and fuels new discoveries.

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IntAct @intact-ebi.bsky.social · 01/10/2025

🕸️ Explore the interactome on the IntAct tinyurl.com/35922511. 🆕 New feature: You can now group nodes by orthology 🧩 — stay tuned for more details! #Immunology #Proteomics #MolecularInteractions #HumanImmuneSystem

IntAct @intact-ebi.bsky.social · 01/10/2025

🧬 “A physical wiring diagram for the human immune system” by the Wright Lab, University of York. 🔎 Study provides a systematic & quantitative view of the cell-surface proteins that enable immune cells to dynamically wire their interactions.

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ComplexPortal @complexportal.bsky.social · 01/10/2025

The minor spliceosome removes rare U12-type introns—found in essential genes for cell division, DNA repair, and development. New entries in the Complex Portal cover its snRNPs (U11, U12, U4atac, U6atac) and active B-act complex (CPX-26509): tinyurl.com/4wxhkymf 🔬 More info: tinyurl.com/47ed3er6

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PRIDE Database @pride-ebi.bsky.social · 01/10/2025

PXD063858 🚨 Detection of TDP-43 - TAU interactions by XL-MS. 🚨 New dataset alert! 🚨

IntAct @intact-ebi.bsky.social · 22/09/2025

Reposted by IntAct

💜🧠 World Alzheimer’s Day 🧠💜 IntAct highlights Tau-F 🧵 & amyloid beta 🧩 PPINs from human brain tissue. The Tau-F network shows mutations P301L/S 🧪 disrupting key pathways linked to Alzheimer’s. 🔗 Network: tinyurl.com/ynjwhy7y Paper: doi.org/10.3390/ijms24032490 #WorldAlzheimersDay #AlzheimersSociety

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ComplexPortal @complexportal.bsky.social · 22/09/2025

🧠 Today is #WorldAlzheimersDay. 📚 Visit the Complex Portal and learn more about gamma-secretase complexes, key to precise cleavage of amyloid precursor protein (APP), who's dysfunction is linked to disease progression (tinyurl.com/37exu532). #WorldAlzheimersDay #AlzheimersSociety #Complexportal

IntAct @intact-ebi.bsky.social · 22/09/2025

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IntAct @intact-ebi.bsky.social · 22/09/2025

IntAct @intact-ebi.bsky.social · 12/09/2025

IntAct release 251 is out! 1,726,205 binary interactions from 23,716 manually curated publications www.ebi.ac.uk/intact/about... (in sync with UniProt release 2025_03)

IntAct @intact-ebi.bsky.social · 08/09/2025

🧠 Alzheimer’s research meets precision medicine 📊 IMEx data from IntAct & Complex Portal 🧬 How AD mutations disrupt brain protein networks 🔍 Variant pathways, APP, miRNA 🚀 Toward targeted AD therapies 🔗 doi.org/10.1002/pmic... #KalpanaPannerselvam #IntAct #ComplexPortal #AlzheimersSociety

IntAct @intact-ebi.bsky.social · 08/09/2025

🧬 New in IntAct: Curated dataset from Pichlmair lab reveals VZV–host interactions in SK-N-BE2 cells. NPHP4 identified as a restriction factor; S862N variant alters interactome. 🎉Congrats Virginie Girault et al! 🔍 Explore: www.ebi.ac.uk/intact/searc... #IntAct #HostPathogen #@a_pichlmair

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ComplexPortal @complexportal.bsky.social · 28/08/2025

🧠 Ever wonder how your tongue detects umami or sweetness? 🧂 Umami is sensed by a GPCR made of TAS1R1 + TAS1R3; sweet by TAS1R2 + TAS1R3. 🍜 Both trigger gustducin proteins, sending signals to your brain (and beyond). 🔬 Learn more: Complex Portal: tinyurl.com/ymd4ews9 #TasteReceptors #GPCR

ComplexPortal @complexportal.bsky.social · 28/08/2025

Reposted by IntAct

Complex Portal release 251 is out! 5,190 manually curated biological complexes. www.ebi.ac.uk/complexporta... (in sync with UniProt release 2025_03)

IntAct @intact-ebi.bsky.social · 03/07/2025

Excited to share the global proximity interactome in the Human Macroautophagy Pathway! (See: tinyurl.com/bdfaeztn) Study uncovers novel role of OSBPL family lipid transport proteins as new players in autophagy.See IntAct: tinyurl.com/34ksav36 #Macroautophagy #BrumellLab

IntAct @intact-ebi.bsky.social · 03/07/2025

Excited to share the global proximity interactome in the Human Macroautophagy Pathway! (PMID: 34524948). Study uncovers novel putative connections including identification of OSBPL family lipid transport proteins as new players in autophagy.See IntAct: tinyurl.com/34ksav36 #Macroautophagy#BrumellLab

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EMBL-EBI @ebi.embl.org · 30/06/2025

Do you use EMBL-EBI data resources? We would really appreciate your feedback! Our Interim Director Jo McEntyre explains how you can help us demonstrate the value of our data resources: www.ebi.ac.uk/about/news/a... Survey closes on 16 July: www.surveymonkey.com/r/QGFMBH8?ch... Thank you!

ebi.ac.uk

User survey to understand the value of open data resources

EMBL-EBI user survey opens – please complete it before 16 July

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ComplexPortal @complexportal.bsky.social · 27/06/2025

Do you want to learn more about macromolecular complexes? Register for our webinar taking place on 𝗝𝘂𝗹𝘆 𝟵𝘁𝗵, 𝟮𝟬𝟮𝟱! 📅 🔍 Discover more about our latest updates including the Complex Navigator & the integration of ML-predicted complexes (huMap3.0 and MuSIC). ➡️ Register now: tinyurl.com/bdy6wttv

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EMBL Events @events.embl.org · 25/06/2025

What do Nobel laureates, early-career researchers, and pioneering scientists have in common? 🧬 They all attend EMBL Events! Want in? Whether you're into molecules, cells, or data – there's something for you! 🚀 Subscribe now and stay in the loop: 👉 eepurl.com/dv95w9

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IntAct @intact-ebi.bsky.social · 02/06/2025

IntAct's dataset of the month features 75 cancer-associated missense variants in the retinoblastoma tumor suppressor protein (PMID:39938803). Visit IntAct and explore detailed expert-curation of variants, binding domains and biophysical parameters (tinyurl.com/4rsx8754). #C..., #PPI, #IntActEBI

Kevin Drew @ksdrew.bsky.social · 30/05/2025

Reposted by IntAct

First off, this was a wonderful collaboration with @gkust.bsky.social, @kourtissavvas.bsky.social, @sdelcilab.bsky.social, and folks at @complexportal.bsky.social specifically Henning Hermjakob and Sandra Orchard. The project was beautifully led by Sam Fischer and Erin Claussen from my lab.

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ComplexPortal @complexportal.bsky.social · 21/05/2025

May is skin cancer awareness month! We're highlighting Telomerase holoenzyme complex (CPX-265) featuring TERT(UniProt:O14746). ComplexPortal: tinyurl.com/mt7u4wbs & visit UniProt for all melanoma-linked proteins tinyurl.com/mryjvyu7 #MelanomaAwareness, #ComplexPortal, #IntAct-EBI, #UniProt

IntAct @intact-ebi.bsky.social · 21/05/2025

It is Skin Cancer awareness month! Explore manually curated interactomes of proteins associated with familial melanoma in IntAct. Access the network in IntAct (tinyurl.com/26tc7xtm). #IntAct-ebi, #ComplexPortal, #UniProt, #MelanomaAwareness, #HumanDisease, #SunSafety, #SpotSkinCancer,