iiinova — where your digital self keeps evolving

👏 A big thanks to Élodie Monsellier @emonsellier.bsky.social and the team for their collaboration in bringing this integration to IntAct! #IntActEBI #PPI #NetworkBiology

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👏 A big thanks to Élodie Monsellier @emonsellier.bsky.social and the team for their collaboration in bringing this integration to IntAct! #IntActEBI #PPI #NetworkBiology

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📌 Each interaction includes 𝐛𝐢𝐧𝐝𝐢𝐧𝐠 𝐚𝐟𝐟𝐢𝐧𝐢𝐭𝐲 (𝐊𝐝), so you can see not just if proteins interact, but how strongly. 🚀 Enabling better network biology, pathway modeling, variant interpretation & drug discovery. Freely accessible via IntAct: tinyurl.com/2u86jtv5

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🔬✨ New in 𝐈𝐧𝐭𝐀𝐜𝐭! Quantitative fragmentomics data (Nat Commun 2022) now integrated into IntAct - bringing high-quality, quantitative protein-protein interactions to the database.

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👏 A big thanks to Élodie Monsellier @emonsellier.bsky.social and the team for their collaboration in bringing this integration to IntAct! #IntActEBI #PPI #NetworkBiology

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🔬✨ New in 𝐈𝐧𝐭𝐀𝐜𝐭! 𝐐𝐮𝐚𝐧𝐭𝐢𝐭𝐚𝐭𝐢𝐯𝐞 𝐟𝐫𝐚𝐠𝐦𝐞𝐧𝐭𝐨𝐦𝐢𝐜𝐬 𝐝𝐚𝐭𝐚 (Nat Commun 2022) now integrated into IntAct - bringing high-quality, quantitative protein-protein interactions to the database.

IntAct @intact-ebi.bsky.social · 28/01/2026

IntAct release 252 is out! 1,787,152 binary interactions from 23,889 manually curated publications www.ebi.ac.uk/intact/about... (in sync with UniProt release 2025_04)

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Reposted by IntAct

👏 Huge thanks to UniProt for integrating the isoform information! 🤝 This was a joint curation effort by IntAct and UniProt, and a great example of collaborative science. Here’s to an exciting year ahead! 🚀🧬 tinyurl.com/N-terminal-p... #EMBLEBI #IntActEBI #UniProt #Proteoforms

Study beautifully demonstrates how N-terminal proteoforms can reshape protein interactomes - gaining new interactions and/or losing others compared to their canonical counterparts - highlighting the power of proteoform diversity in cellular networks.

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🎉✨ Happy 2026! ✨🎉 We’re excited to kick off the year by sharing the integration of the work “N-terminal proteoforms may engage in different protein complexes” from the Kris Gevaert lab (VIB, Ghent, Belgium) 🎓🔬

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Reposted by IntAct

Registration is free but essential: tinyurl.com/4v3jf4e9 Speakers: Susie H. and Eliot Ragueneau #Bioinformatics #IntAct #Modelling #BiologicalNetworks #Cytoscape

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Reposted by IntAct

EMBL-EBI @ebi.embl.org · 25/11/2025

Would you like to learn more about molecular interactions and how to explore them across organisms? Join us next week for an introductory webinar where we will walk through the IntAct Portal's approach to molecular network modelling and show how this is implemented within the IntAct Cytoscape app.

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Reposted by IntAct

From a farm in the north of England to the frontiers of bioinformatics, our Group Leader Sandra Orchard reflects on a career building the data foundations of modern biology: “AI is showing how vital data curation really is.” www.ebi.ac.uk/about/news/p... 🖥️🧬

ebi.ac.uk

Sandra Orchard: what I’ve learned

EMBL-EBI Team Leader Sandra Orchard reflects on a life in protein science, UniProt data curation, and championing open data standards.

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Reposted by IntAct

EMBL-EBI @ebi.embl.org · 25/11/2025

Upon her retirement from EMBL-EBI, we thank Sandra for her dedication and foundational work on important open data resources including: UniProt Complex Portal @complexportal.bsky.social Gene Ontology @geneontology.bsky.social IntAct @intact-ebi.bsky.social InterPro @interprodb.bsky.social

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Registration is free but essential: tinyurl.com/4v3jf4e9 Speakers: Susie H. and Eliot Ragueneau #Bioinformatics #IntAct #Modelling #BiologicalNetworks #Cytoscape

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Reposted by IntAct

🧫 Explore the curated dataset in IntAct ➡️ tinyurl.com/candidalysin 🎨IntAct Cytoscape visualisation: Candida albicans ECE1 peptides (orange) and their human protein targets (blue) #IntActEBI #Interactome #EMBL

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Maps the interactome of all eight Candida albicans ECE1 propeptides and their specific human protein targets, revealing both unique and shared host interactions that provide new insights into fungal–host communication.

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ComplexPortal @complexportal.bsky.social · 19/10/2025

✨🧬New on IntAct! ✨ Interaction data from the study 📖“Global fungal–host interactome mapping identifies host targets of candidalysin” - Shanghai Jiao Tong University, Tongji University, and the Chinese Academy of Sciences. 🎉

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Reposted by IntAct

Let’s make your science more FAIR - Findable, Accessible, Interoperable, and Reusable. #Biocuration #FromBenchToDatabase #FAIRdata #ProteinInteractions #EMBL-EBI #IntAct-EBI #OpenScience #UniProt #DataMatters

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Reposted by IntAct

ComplexPortal @complexportal.bsky.social · 19/10/2025

📥 Submit your data here: 🔹 IntAct: tinyurl.com/zzrcx742

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Reposted by IntAct

ComplexPortal @complexportal.bsky.social · 19/10/2025

Want your PPI or structural data to make an impact? ✅ Use Identifierss ✅ Include structured tables (e.g. Niri et al. 2021 - PMID: 34197713) ✅ Submit to EMBL-EBI's data resources - IntAct 👉 See Niri’s dataset in IntAct: tinyurl.com/yp8ddheh

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Reposted by IntAct

ComplexPortal @complexportal.bsky.social · 19/10/2025

Don’t just publish - be found! 🔍 I didn’t realize how vital biocuration was until I became a curator. A well-curated dataset doesn’t just sit in a paper - it lives on in databases and fuels new discoveries.

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Reposted by IntAct

🕸️ Explore the interactome on the IntAct tinyurl.com/35922511. 🆕 New feature: You can now group nodes by orthology 🧩 — stay tuned for more details! #Immunology #Proteomics #MolecularInteractions #HumanImmuneSystem

🧬 “A physical wiring diagram for the human immune system” by the Wright Lab, University of York. 🔎 Study provides a systematic & quantitative view of the cell-surface proteins that enable immune cells to dynamically wire their interactions.

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ComplexPortal @complexportal.bsky.social · 01/10/2025

tinyurl.com

IntAct Portal

EMBL-EBI

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Reposted by IntAct

The minor spliceosome removes rare U12-type introns—found in essential genes for cell division, DNA repair, and development. New entries in the Complex Portal cover its snRNPs (U11, U12, U4atac, U6atac) and active B-act complex (CPX-26509): tinyurl.com/4wxhkymf 🔬 More info: tinyurl.com/47ed3er6

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Reposted by IntAct

PRIDE Database @pride-ebi.bsky.social · 01/10/2025

PXD063858 🚨 Detection of TDP-43 - TAU interactions by XL-MS. 🚨 New dataset alert! 🚨

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Reposted by IntAct

IntAct @intact-ebi.bsky.social · 22/09/2025

💜🧠 World Alzheimer’s Day 🧠💜 IntAct highlights Tau-F 🧵 & amyloid beta 🧩 PPINs from human brain tissue. The Tau-F network shows mutations P301L/S 🧪 disrupting key pathways linked to Alzheimer’s. 🔗 Network: tinyurl.com/ynjwhy7y Paper: doi.org/10.3390/ijms24032490 #WorldAlzheimersDay #AlzheimersSociety

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Reposted by IntAct

ComplexPortal @complexportal.bsky.social · 22/09/2025

🧠 Today is #WorldAlzheimersDay. 📚 Visit the Complex Portal and learn more about gamma-secretase complexes, key to precise cleavage of amyloid precursor protein (APP), who's dysfunction is linked to disease progression (tinyurl.com/37exu532). #WorldAlzheimersDay #AlzheimersSociety #Complexportal

IntAct @intact-ebi.bsky.social · 22/09/2025

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IntAct @intact-ebi.bsky.social · 22/09/2025

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IntAct @intact-ebi.bsky.social · 12/09/2025

IntAct release 251 is out! 1,726,205 binary interactions from 23,716 manually curated publications www.ebi.ac.uk/intact/about... (in sync with UniProt release 2025_03)

IntAct @intact-ebi.bsky.social · 08/09/2025

🧠 Alzheimer’s research meets precision medicine 📊 IMEx data from IntAct & Complex Portal 🧬 How AD mutations disrupt brain protein networks 🔍 Variant pathways, APP, miRNA 🚀 Toward targeted AD therapies 🔗 doi.org/10.1002/pmic... #KalpanaPannerselvam #IntAct #ComplexPortal #AlzheimersSociety

IntAct @intact-ebi.bsky.social · 08/09/2025

🧬 New in IntAct: Curated dataset from Pichlmair lab reveals VZV–host interactions in SK-N-BE2 cells. NPHP4 identified as a restriction factor; S862N variant alters interactome. 🎉Congrats Virginie Girault et al! 🔍 Explore: www.ebi.ac.uk/intact/searc... #IntAct #HostPathogen #@a_pichlmair

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Reposted by IntAct

ComplexPortal @complexportal.bsky.social · 28/08/2025

🧠 Ever wonder how your tongue detects umami or sweetness? 🧂 Umami is sensed by a GPCR made of TAS1R1 + TAS1R3; sweet by TAS1R2 + TAS1R3. 🍜 Both trigger gustducin proteins, sending signals to your brain (and beyond). 🔬 Learn more: Complex Portal: tinyurl.com/ymd4ews9 #TasteReceptors #GPCR

ComplexPortal @complexportal.bsky.social · 28/08/2025

Reposted by IntAct

Complex Portal release 251 is out! 5,190 manually curated biological complexes. www.ebi.ac.uk/complexporta... (in sync with UniProt release 2025_03)

IntAct @intact-ebi.bsky.social · 03/07/2025

Excited to share the global proximity interactome in the Human Macroautophagy Pathway! (See: tinyurl.com/bdfaeztn) Study uncovers novel role of OSBPL family lipid transport proteins as new players in autophagy.See IntAct: tinyurl.com/34ksav36 #Macroautophagy #BrumellLab