Sign in

Inserm UMR 1069 N2COx

@inserm-u1069-n2cox.bsky.social
523 followers 266 following 15 posts

Projects focused on lipids acting in/on tumor niches, particularly on energy/oxidative metabolism and calcium signaling, able to influence dysplasia, tumor progression and sensitivity of tumors to anti-cancer drugs University of Tours - France

PostsRepliesMedia
Reposted by Inserm UMR 1069 N2COx
yEFIS @yefis-immunology.bsky.social · 08/01/2026
🧬 Postdoc Opportunity Junior postdoctoral position in spatial transcriptomics & immunology at Inserm UMR1227 (Brest, France). Focus on Visium HD, Xenium, CosMx and single-cell transcriptomics in Sjögren’s disease. 📩 marie.frutoso@univ-brest.fr 🔗 More info: www.yefis.org/resources/jo...
yefis.org
Postdoctoral researcher in spatial transcriptomics and immunology
126
Inserm UMR 1069 N2COx @inserm-u1069-n2cox.bsky.social · 10/10/2025
Excited to share our work in Cell Communication and Signalling @springernature.com rdcu.be/eJe8l Groundbreaking approach using Ca²⁺ signatures to capture the unique characteristics of cancer cells. Collab with LIFAT Tours University @inserm.fr @insermgrandouest.bsky.social @chrudetours.bsky.social
rdcu.be
Investigation of the heterogeneity of cancer cells using single cell Ca2+ profiling
020
Inserm UMR 1069 N2COx @inserm-u1069-n2cox.bsky.social · 07/08/2025
Delighted to share our new article www.sciencedirect.com/science/arti... in Clinical immunology @elsevierhms.bsky.social @inserm.fr @insermgrandouest.bsky.social @chrudetours.bsky.social in collaboration with Pr Delhommeau's team @sorbonne-universite.fr #cytokines #leukemia #institut_Carnot_Opale
sciencedirect.com
A specific bone marrow cytokine pattern in de novo acute myeloid leukemia
Acute myeloid leukemia (AML) is a heterogeneous group of hematopoietic cancers. Cytokines play an important role in the regulation of normal and patho…
020
Reposted by Inserm UMR 1069 N2COx
Cancéropole Grand Ouest @canceropolego.bsky.social · 24/07/2025
🔬 @cnrs.fr @inserm-u1069-n2cox.bsky.social @inserm.fr @igdrennes.bsky.social @chunantes.bsky.social @insermgrandouest.bsky.social @cnrs-bretagneloire.bsky.social #cancer #cancerologie #oncologie #recherche #grandouest #cancersein #cancerdusein #cancerprostate #cancerdelaprostate
011
Inserm UMR 1069 N2COx @inserm-u1069-n2cox.bsky.social · 09/04/2025
Thrilled to share our collaborative review exploring the resemblance of pulmonary arterial hypertension and cancers as channelopathies @cellpress.bsky.social Trends in Molecular Medicine @inserm.fr Inserm UMR 999 @univparissaclay.bsky.social Université de Tours www.sciencedirect.com/science/arti...
sciencedirect.com
Pulmonary arterial hypertension and cancer: exploring their resemblance as channelopathies
Pulmonary arterial hypertension (PAH) and cancer may appear to be unrelated at first, but there is increasing evidence that they share many characteri…
040
Inserm UMR 1069 N2COx @inserm-u1069-n2cox.bsky.social · 07/03/2025
www.univ-tours.fr/recherche/ac...
univ-tours.fr
L'université de Tours s'associe au mouvement international Stand-up for Science
050
Reposted by Inserm UMR 1069 N2COx
Inserm @inserm.fr · 25/02/2025
L’Inserm rejoint Bluesky ! Découvrez ici toutes les actualités de la recherche médicale menée par l’Inserm, pour la santé de toutes et tous.
Image décorative.
1016251
Reposted by Inserm UMR 1069 N2COx
David Gaboriau @dgaboriau.bsky.social · 14/02/2025
An oldie but a goodie! DNA, mitochondria, actin and tubulin for #fluorescencefriday
0342
Reposted by Inserm UMR 1069 N2COx
Nature Cell Biology @natcellbio.nature.com · 17/02/2025
💫NEW: @zakbaker.bsky.social, Pagliarini & co show that #mitochondria stress recovery requires mobilization of #LipidDroplet triacylglycerol stores to facilitate #cardiolipin biosynthesis and mitochondrial biogenesis. www.nature.com/articles/s41...
nature.com
Triacylglycerol mobilization underpins mitochondrial stress recovery - Nature Cell Biology
Baker et al. show that mitochondrial stress recovery requires mobilization of lipid droplet triacylglycerol stores to facilitate cardiolipin biosynthesis and mitochondrial biogenesis.
1348
Inserm UMR 1069 N2COx @inserm-u1069-n2cox.bsky.social · 19/02/2025
Very pleased to share our last collaborative publication with Child team #CRCI2NA @inserm.fr @insermgrandouest.bsky.social #cancéropole_Grand_Ouest #Ewing_sarcoma #KCNA2 #Kv1.2 #EWS::FLI1 #YAP/Hippo biosignaling.biomedcentral.com/articles/10....
biosignaling.biomedcentral.com
Transcriptional regulation of KCNA2 coding Kv1.2 by EWS::FLI1: involvement in controlling the YAP/Hippo signalling pathway and cell proliferation - Cell Communication and Signaling
Background Ewing sarcoma (ES), the second main pediatric bone sarcoma, is characterised by a chromosomal translocation leading to the formation of fusion proteins like EWS::FLI1. While several studies...
010
Reposted by Inserm UMR 1069 N2COx
Jean-Ehrland RICCI @jer-06.bsky.social · 28/01/2025
www.cell.com/cell-metabol...
cell.com
Redirecting glucose flux during in vitro expansion generates epigenetically and metabolically superior T cells for cancer immunotherapy
T cell therapies for cancer currently rely on extensive in vitro expansion in hypermetabolic conditions. Frisch et al. demonstrate that T cells grown in vitro perform extensive aerobic glycolysis. Rer...
041
Reposted by Inserm UMR 1069 N2COx
Armelle Rancillac 🔬 @rancillac.bsky.social · 24/01/2025
Our latest paper is out: Unveiling the Functional Connectivity of Astrocytic Networks with AstroNet Dive into how our graph reconstruction algorithm, paired with calcium image processing, deciphers astrocytic networks. 👉 doi.org/10.1038/s420... #Astrocytes #Neuroscience #DataScience #Inserm
0124
Reposted by Inserm UMR 1069 N2COx
France Universités @franceuniversites.bsky.social · 24/01/2025
#Budget2025. Les universités font face à une crise financière sans précédent ! Université : vivre ou survivre ? Podcast de @franceculture.fr avec Edouard kaminski : 👉 www.radiofrance.fr/francecultur...
radiofrance.fr
Université : vivre ou survivre ?
Avec près de 80% des universités en déficit, la France a-t-elle laissé tomber l’université ? Reste-t-il des raisons d’espérer pour l’enseignement supérieur public ?
12011
Inserm UMR 1069 N2COx @inserm-u1069-n2cox.bsky.social · 24/01/2025
Cancers les plus fréquents : le rôle du « gras » dans leur prévention et leur évolution @insermgrandouest.bsky.social @france.theconversation.com #nutrition #cancer #lipides #acides-gras #oméga-3 theconversation.com/cancers-les-...
theconversation.com
Cancers les plus fréquents : le rôle du « gras » dans leur prévention et leur évolution
Le gras influence certains cancers fréquents. Le rôle préventif des acides gras oméga-3 est bien documenté. Mais l'impact de la graisse en excès dans les situations d'obésité reste mal compris.
061
Reposted by Inserm UMR 1069 N2COx
Nature Cancer @natcancer.nature.com · 24/01/2025
Online now! Puigserver and team show that genetic targeting of specific mitochondrial respiratory complex I subunits in melanoma and breast cancer cells boosts tumor immune surveillance via upregulation of antigen-processing and presentation components. 👇 www.nature.com/articles/s43...
nature.com
Selective deficiency of mitochondrial respiratory complex I subunits Ndufs4/6 causes tumor immunogenicity - Nature Cancer
Puigserver and colleagues show that genetic targeting of specific mitochondrial respiratory complex I subunits in melanoma and breast cancer cells boosts tumor immune surveillance via upregulation of ...
1218
Reposted by Inserm UMR 1069 N2COx
Elodie Lafont @elodie-lafont.bsky.social · 23/01/2025
rdcu.be/d7aW7
rdcu.be
Immune evasion through mitochondrial transfer in the tumour microenvironment
Nature - Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired...
032
Reposted by Inserm UMR 1069 N2COx
Fondation ARC pour la recherche sur le cancer @fondationarc.bsky.social · 23/01/2025
☣️ 𝗖𝗮𝗻𝗰𝗲𝗿𝘀 𝗱𝘂 𝗽𝗮𝗻𝗰𝗿𝗲́𝗮𝘀 𝗲𝘁 𝗽𝗲𝘀𝘁𝗶𝗰𝗶𝗱𝗲𝘀, 𝘂𝗻𝗲 𝗮𝗹𝗲𝗿𝘁𝗲 𝗲́𝗺𝗲𝗿𝗴𝗲𝗻𝘁𝗲 ? ☣️ Deux études françaises récentes, menées selon deux approches complémentaires par Mathias Brugel et ses collaborateurs, interrogent le rôle des pesticides dans la hausse des cas de cancers du pancréas.
274
Reposted by Inserm UMR 1069 N2COx
Dr Elodie Chabrol @eloscicomm.bsky.social · 22/01/2025
Voici un starter pack pour suivre la recherche en France : instituts, laboratoires, universités et agences. N'hésitez pas à proposer des comptes à ajouter ! go.bsky.app/JSXcYqn
64297156
Inserm UMR 1069 N2COx @inserm-u1069-n2cox.bsky.social · 23/01/2025
Our research topics: #Oncology/Hematological malignancies #lipids #prevention #redox/energy metabolism #Sensitization of tumors to anticancer treatments #biology of cancer cells #ion channels #calcium homeostasis #clinical nutrition #cachexia #mitochondria www.lestudium-ias.com/regional-eco...
lestudium-ias.com
Niche, Nutrition, Cancer & métabolisme Oxidatif (N2COX) | LE STUDIUM
Notre projet de recherche est celui d’une monoéquipe multidisciplinaire centré sur les lipides agissant dans/sur les niches tumorales, plus particulièrement sur le métabolisme énergétique/oxydatif et ...
020
Reposted by Inserm UMR 1069 N2COx
Dylan Burnette @mag2art.bsky.social · 20/01/2025
A cancer cell with three nuclei (cyan) videoed through a microscope. Mitochondria (yellow) and the actin cytoskeleton (red) are also shown. #Science #Biology #CellBiology #microscopy
1519
Inserm UMR 1069 N2COx @inserm-u1069-n2cox.bsky.social · 20/01/2025
New publication "Chimeric protein EWS::FLI1 drives cell proliferation in Ewing Sarcoma via aberrant expression of KCNN1/SK1 and dysregulation of calcium signaling" @natureportfolio.bsky.social fruitful collaborative project with CRCI2NA @insermgrandouest.bsky.social www.nature.com/articles/s41...
nature.com
Chimeric protein EWS::FLI1 drives cell proliferation in Ewing Sarcoma via aberrant expression of KCNN1/SK1 and dysregulation of calcium signaling - Oncogene
Oncogene - Chimeric protein EWS::FLI1 drives cell proliferation in Ewing Sarcoma via aberrant expression of KCNN1/SK1 and dysregulation of calcium signaling
021
Inserm UMR 1069 N2COx @inserm-u1069-n2cox.bsky.social · 20/01/2025
Pleased to share our article @insermgrandouest.bsky.social @CHRU Tours @Etablissement Français du Sang Peripheral blood lactate kinetics may reflect immune cells activation and be useful for bedside monitoring in non-Hodgkin lymphoma #immunometabolism onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
Glycolytic activity following anti‐CD19 CAR‐T cell infusion in non‐Hodgkin lymphoma
Energy metabolism of chimeric antigen receptor-T cells (CAR-T) activation in humans remains unexplored. As a glycolytic activity surrogate, we investigated the dynamics of peripheral blood (PB) lacta...
021
Inserm UMR 1069 N2COx @inserm-u1069-n2cox.bsky.social · 20/01/2025
Recherche à Tours en Région Centre Val-de-Loire @inserm.fr @insermgrandouest.bsky.social Université de Tours Sardines, maquereaux et autres poissons gras : contre le cancer, l’intérêt des oméga-3 et lipides du milieu marin theconversation.com/sardines-maq... #FDS2024
theconversation.com
Sardines, maquereaux et autres poissons gras : contre le cancer, l’intérêt des oméga-3 et lipides du milieu marin
Les lipides issus du milieu marin se révèlent prometteurs contre les cancers. Soit en prévention à l’image des oméga-3 présents dans certains aliments (sardines, maquereaux…). Soit pour développer des...
021
Inserm UMR 1069 N2COx @inserm-u1069-n2cox.bsky.social · 20/01/2025
Thrilled to share our research "MICU2 up-regulation enhances tumor aggressiveness and metabolic reprogramming during colorectal cancer development" in @plosbiology.org ! Hard work of Inserm N2COx team in Tours and our collaborators at Inserm MITOVASC team in Angers journals.plos.org/plosbiology/...
111
Inserm UMR 1069 N2COx @inserm-u1069-n2cox.bsky.social · 20/01/2025
Save the date ! From June 23 to 26, Ion channel Signaling in Health and Disease conference @insermgrandouest.bsky.social to be held at Château Belmont, Tours. Under the patronage of LE STUDIUM Loire Valley Institute for Advanced Studies www.lestudium-ias.com/events/ion-c...
lestudium-ias.com
Ion channel signaling in health and disease | LE STUDIUM
Mohamed Trebak, Marie Potier-Cartereau & Chistophe Vandier
111
Inserm UMR 1069 N2COx @inserm-u1069-n2cox.bsky.social · 20/01/2025
Pleased to share this article on medicinal chemistry @insermgrandouest.bsky.social @inserm.fr Université de Tours www.sciencedirect.com/science/arti... #inhibitors #tri-heterocyclic #colorectal #cancer ! Thanks to Ligue contre le cancer, Labex SynOrg and @frm-officiel.bsky.social ImPACcell KissF
sciencedirect.com
Synthesis and biological evaluation of new tri-heterocyclic derivatives as anti-colorectal cancer agents
Colorectal cancer is a major health problem, with a poor prognosis if not detected at early stage. It is the third most common cancer worldwide and th…
031