y of patients relapse, which is concomitant with poor CAR T cell persistence. Similarly, the efficacy of CAR T cell therapy is limited in solid tumors, largely due to tumor antigen heterogeneity, immu...

TEPP-46 activates PKM2 by inducing a tetramer formation, which leads to a metabolic reprogramming in macrophages, resulting in an increase in ATP and IL-10 production. Toller-Kawahisa et al. showed th...

The circadian clock, orchestrated by BMAL1, regulates the expression of Nlrp3 and Il1b in response to lipopolysaccharide (LPS), causing time-of-day production of pro-IL-1β. Mitochondria exhibit time-....

The metabolic landscape of cancer greatly influences antitumor immunity, yet it remains unclear how organ-specific metabolites in the tumor microenvironment influence immunosurveillance. We found that...

Baker et al. show that mitochondrial stress recovery requires mobilization of lipid droplet triacylglycerol stores to facilitate cardiolipin biosynthesis and mitochondrial biogenesis.

Zhai, Yang et al. report a central role for AMPK in regulating aldolase B-mediated glycerol synthesis and excretion under hypoxia as a mechanism to balance the trade-off between reductive and energy s...

The intersection between cellular metabolism and innate immunity lacks understanding. Here, Rao and Qin et al. report that the metabolic enzyme, CTP synthetase 1, deamidates IRF3 to limit interferon induction, independent of its role in pyrimidine synthesis. This reveals how a key metabolic enzyme directly regulates innate immune activation.

Acute oral metformin administration lowers blood glucose levels by targeting mitochondrial complex I.

Posttranslational modifications play a crucial role in regulating autophagy and lysosome–related transcription factor TFEB. Huang et al. find the increase

imageimageWhether cholesterol biosynthesis can be adjusted to the availability of input carbon sources remains unclear. This study demonstrates that glutamine is directly sensed by and required for ac...

Impaired mitochondrial bioenergetics in macrophages can drive hyperinflammatory cytokine responses, but whether this may also be caused by inherited mtDNA mutations is unknown. Here, we address this q...

Lymph node swelling is a well-known symptom of infection. A shift in the chemoattractant code controls lymphocyte recruitment from blood into inflamed lymph nodes, allowing lymphocytes to accumulate so that even rare antigen-specific cells can encounter their activating antigen.

Resting human CD56Dim natural killer cells utilize exogenous pyruvate to support energy metabolism. A new study shows that these cells take up exogenous pyruvate, which regenerates cytosolic NAD+ via ...

Mechanisms of prostaglandin E2 (PGE2)-mediated immunosuppression in the tumor microenvironment (TME) have been previously reported. Here, the authors profile PGE2 functions in human cancer, suggesting...

Glutamine modulates neutrophil responses during sterile inflammation.

Immune cells that release the molecule IL-17A help to drive the metabolic rhythms of fat.

We show that target-induced proximity labelling enables isolation of first-division CD8 chimeric antigen receptor T cells that asymmetrically distribute their surface proteome and transcriptome, resul...

In brief, Lin et al. demonstrate that SLC13A3 functions as an itaconate transporter, allowing tumor cells to uptake macrophage-derived itaconate through SLC13A3. This process contributes to tumor resi...

It has been reported that itaconate is an immunoregulatory metabolite secreted by activated myeloid cells, including neutrophils and macrophages. Here, Chen et al. demonstrate that SLC13A3 is an itaco...

Dong et al. find that commonly prescribed antidepressants, SSRIs, have significant anti-tumor effects in HCC. SSRIs, including citalopram, target GLUT1 instead of their classical target, SERT, leading...

Nature Microbiology - Increased IL-13 drives increased bacterial dissemination and mortality following Acinetobacter baumannii lung infection of zinc-deficient mice and can be countered by...

imageimageWhether cholesterol biosynthesis can be adjusted to the availability of input carbon sources remains unclear. This study demonstrates that glutamine is directly sensed by and required for ac...