🎉Thrilled to share that our second paper of the summer has just been published in PLOS ONE! 😃 Six Providence College students are co-authors on this study, where we investigated the role of the mTORC1 pathway in the development of microglia in a mouse model of NPC
journals.plos.org/plosone/arti...
journals.plos.org
Role of mTORC1 signaling in postnatal microglia activation preceding neurodegeneration in a mouse model for Niemann-Pick disease Type C
In Npc1 deficient mice, postnatal developmental alterations in cerebellar microglia and Purkinje cells (PCs) are followed by early-onset neurodegeneration. Even in the absence of PC loss, microglia in...