Abstract. Bacterial genomes encompass numerous small open reading frames (smORFs), some of which encode functional microproteins or perform noncoding regul

Small secreted peptides (SSPs) play an important role in modulating immune responses in all land plants. However, the evolution of stress peptide signaling in different plant phyla remains poorly und...

In addition to photosynthesis, chloroplasts perform a variety of important cellular functions in the plant cell, which can, for example, regulate plant responses to abiotic and biotic stress conditio...

Background Protein degradation is a basic cell process that operates in general protein turnover or to produce bioactive peptides. However, very little is known about the qualitative and quantitative ...

Background Cryptic peptides (cryptides) are small bioactive molecules generated via degradation of functionally active proteins. Only a few examples of plant cryptides playing an important role in pla...

Proteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics that...

This study uncovers thousands of microprotein families encoded by intergenic small open reading frames (smORFs) in bacterial genomes and provides a publicly available resource featuring structural predictions, predicted interactions between microproteins…

This study uncovers thousands of microprotein families encoded by intergenic small open reading frames (smORFs) in bacterial genomes and provides a publicly available resource featuring structural pre...

The Princess Máxima Center for pediatric oncology is a unique interdisciplinary institute that brings together all the highly complex care, research, and education to provide the best possible care fo...

More than three billion years of evolution have produced an image of biology encoded into the space of natural proteins. Here we show that language models trained at scale on evolutionary data can gen...

The trials and tribulations of the world’s first seed bank reveal botanists’ enormous generosity and sacrifice during the siege of Leningrad.

Background Over recent years, the van Heesch lab has discovered thousands of new “non-canonical” open reading frames (ncORFs) translated from regions of the genome believed not to code for protein. Ma...

Database confirms that overlooked segments of the genome code for a multitude of tiny proteins

Join us at the Keystone Symposia on Microproteins: from Discovery to Applications, February 2025, in Beverly, with field leaders!