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Reposted by Harriette Van Spall MD MPH 🇨🇦

Donovan Blake @donovanwrites.bsky.social · 17/02/2026

Important work.. recognizing oral diuretic intensification as a meaningful worsening HF event could really improve how trials capture real-world risk and patient outcomes.

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Harriette Van Spall MD MPH 🇨🇦 @hvanspall.bsky.social · 25/01/2026

evidence.nejm.org/doi/full/10.... Worsening #HF requiring oral #diuretic intensification is clinically relevant, associated w ⬆️ ☠️ Here we review #RCT data, propose a standard definition for ODI, argue for its inclusion in primary outcome of HF RCTs, & show how this will ⬆️ trial efficiency

evidence.nejm.org

Oral Diuretic Intensification as a Worsening Heart Failure Event in the Primary Outcome of Clinical Trials

Although evidence-based therapies for patients with heart failure (HF) have decreased all-cause mortality, the residual risk of other clinically relevant outcomes — such as worsening HF — remains h...

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Harriette Van Spall MD MPH 🇨🇦 @hvanspall.bsky.social · 22/01/2026

Among patients with acute #HF in the #CLOROTIC #RCT 💠 #Diuretic resistance -> worse outcomes 💠 #Hydrochlorthiazide effect on weight loss was consistent across categories of diuretic resistance Trial led by JC Trullàs, subanalysis by A Pandey onlinelibrary.wiley.com/doi/10.1002/...

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Harriette Van Spall MD MPH 🇨🇦 @hvanspall.bsky.social · 22/01/2026

2026 #HeartDisease & #Stroke #Statistics: Report of US & Global Data From American Heart Association is here‼️ Did you know that the leading causes of #heartfailure are preventable? CAD (20%) HTN (20%) tobacco (14%) obesity (12%) diabetes (12%) www.ahajournals.org/doi/10.1161/...

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Reposted by Harriette Van Spall MD MPH 🇨🇦

NEJM.org @nejm.org · 31/12/2025

Worsening heart failure is commonly managed w/oral diuretic intensification (ODI). In a new NEJM Evidence article, learn how the inclusion of ODI into trial endpoints could yield consistent treatment effect estimates & improve statistical efficiency. eviden.cc/48zIwEp @hvanspall.bsky.social

Figure 2. Oral Diuretic Intensification as a Worsening Heart Failure Event in the Primary Outcome of Clinical Trials.

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Harriette Van Spall MD MPH 🇨🇦 @hvanspall.bsky.social · 04/10/2025

The eligibility criteria in a trial ensure that appropriate patients are selected. A screening 24 hour Holter monitor will be used to guide patient selection for this trial. Patient will have the comorbidities that are common with this condition.

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Harriette Van Spall MD MPH 🇨🇦 @hvanspall.bsky.social · 03/10/2025

Thank you, we have already enrolled a handful of patients. The pacing rate will be personalized using a simple formula that was tested in an early phase trial.

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Harriette Van Spall MD MPH 🇨🇦 @hvanspall.bsky.social · 17/09/2025

#Medtronic press release on our pivotal #ELEVATE-HFpEF RCT which will test the efficacy & safety of a personalized elevated #pacing rate (based on LVEF & height) in #HFpEF 75 countries 2 patients enrolled already (AUS & US) Methods to be presented at #HFSA25 news.medtronic.com/2025-09-15-M...

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Harriette Van Spall MD MPH 🇨🇦 @hvanspall.bsky.social · 16/08/2025

FDA announces approval for #semaglutide 2.4 mg sc weekly for #MASLD based on results of the #ESSENCE #RCT. Did you know that #CVD is the leading cause of death in patients with #MASLD? Common mechanisms & now, common treatments for #CKLM diseases www.novonordisk.com/news-and-med...

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Harriette Van Spall MD MPH 🇨🇦 @hvanspall.bsky.social · 15/06/2025

Our hearts are with our American friends. Peaceful day here, enjoying a spritzer by the pool. Ms Ella singing.. m.youtube.com/watch?v=S-cb...

m.youtube.com

Etta James - At Last - Lyrics

YouTube video by Jennie Postemus (Preppy52)

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Harriette Van Spall MD MPH 🇨🇦 @hvanspall.bsky.social · 14/06/2025

I love my outdoor #office, where work and play are fully intertwined! What does your #Saturday morning look like? #HappySeason #HomeSweetHome #JoyInWork

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Harriette Van Spall MD MPH 🇨🇦 @hvanspall.bsky.social · 09/06/2025

It’s impossible to uncouple #health from #economic policy Healthiest countries have fair economic policies that allow upward mobility & access to healthier lifestyles Focusing on individual interventions alone: inadequate www.thelancet.com/journals/lan...

thelancet.com

Childhood obesity: prioritising a healthy start

Recent data from National Health Service (NHS) weight clinics in England show that a disproportionate number of referrals originate from the most deprived areas, with some children having BMIs over 40...

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Harriette Van Spall MD MPH 🇨🇦 @hvanspall.bsky.social · 09/06/2025

Phase 3 Trial of #Semaglutide in #Metabolic Dysfunction–Associated #Steatohepatitis In patients with #MASH and moderate or advanced #liver #fibrosis, once-weekly semaglutide at a dose of 2.4 mg improved liver steatohepatitis & fibrosis at 72 weeks t.co/vfcgItgXpb

t.co

https://www.nejm.org/doi/full/10.1056/NEJMoa2413258

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Harriette Van Spall MD MPH 🇨🇦 @hvanspall.bsky.social · 08/06/2025

Regional disparities in participant #enrolment in RCTs are related to regional #disparities in site recruitment relative to 🌎disease distribution We propose estimating site representation index during trial planning to ensure globally (or nationally) representative #RCT popn doi.org/10.1002/ejhf...

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Harriette Van Spall MD MPH 🇨🇦 @hvanspall.bsky.social · 08/06/2025

#NUDGECKD #ERA25 LBT #KristofferSkaar & #TorBiering SimPub #Circulation Pragmatic 2x2 factorial #implementation RCT Randomization at cluster + individual level E-letters re #GDMT to 1540 GPs & 22617 patients w #CKD did not ⬆️ uptake of #RASi or #SGLT2i www.ahajournals.org/doi/10.1161/...

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Reposted by Harriette Van Spall MD MPH 🇨🇦

Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 07/06/2025

Huge Danish trial of nudges Patient level (N 22,000) + practice level (1500 practice cluster with N 28,000 pts) To increase RASination & Flozination www.ahajournals.org/doi/abs/10.1... in @ahajournals.bsky.social at #ERA25 Absolutely null effect - is the baseline too high to improve upon?

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Harriette Van Spall MD MPH 🇨🇦 @hvanspall.bsky.social · 07/06/2025

The views are truly mesmerizing (& distracting as my office overlooks the lake and I find myself just staring at the water instead of getting work done)🙂

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Reposted by Harriette Van Spall MD MPH 🇨🇦

Women As One @womenasone.bsky.social · 03/06/2025

🚨 Missed early registration? No problem. You can still sign up for RISE @ ESC Congress 2025, the essential event for women in cardiology. 📍 Madrid | 🗓️ Aug 28 🎯 Leadership on the Global Stage Register now 👉 rise.womenasone.org #LetsRISE2025 #ESCCongress #WCCardio #CardioSky #WIC

A woman sat at a table whilst having a conversation during RISE @ ESC Congress 2024. Overlain is Information about RISE @ ESC Congress 2025.

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Harriette Van Spall MD MPH 🇨🇦 @hvanspall.bsky.social · 01/06/2025

Ship of #tolerance, created by 2000 school children in our town and displayed in #OakvilleGalleries #GairlochGardens Such a collaborative, moving art display, with ideas communicated in a way that only kids can do.

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Reposted by Harriette Van Spall MD MPH 🇨🇦

Citizens’ Climate Lobby Canada @citizenslobbyca.bsky.social · 27/05/2025

“The true north is indeed, strong and free” A balanced and appropriate speech from the throne on this historical day. Climate change and biodiversity were woven into this speech alongside, not mentioning by name he who shall not be named. m.youtube.com/watch?v=FCzk...

m.youtube.com

LIVE: King Charles presents the speech from the throne in Ottawa | CTV News Special Coverage

YouTube video by CTV News

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Harriette Van Spall MD MPH 🇨🇦 @hvanspall.bsky.social · 24/05/2025

Comrades finding new ways to rewrite history, spread disease, punish their opponents, line their pockets.. you know, business as usual

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Harriette Van Spall MD MPH 🇨🇦 @hvanspall.bsky.social · 23/05/2025

I don’t have an air fryer (have double convection ovens, which do the trick). How did the burgers turn out?

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Harriette Van Spall MD MPH 🇨🇦 @hvanspall.bsky.social · 11/05/2025

The sweetest word in the world, the one I’m most grateful to hear each day, is #mum. #MothersDay2025

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Harriette Van Spall MD MPH 🇨🇦 @hvanspall.bsky.social · 09/05/2025

While #health systems across🌎 are designed around #acute illnesses, 86% of yrs lived w disability & 71% yrs of life lost are from #chronic diseases Burden of chronic dz ⬆️ in higher income countries & w age How to move needle? See our analysis @Nature.bsky.social rdcu.be/ek1MH

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Reposted by Harriette Van Spall MD MPH 🇨🇦

Dr Anastasia S Mihailidou PhD FAHA FCSANZ FESC @anastasiasmihaili.bsky.social · 05/05/2025

📢 #CardioSky #MedSky #NephSky join us👇for our @ahascience.bsky.social #HTNImpact webinar! 🌟Faculty @jordybc.bsky.social @daichishimbo.bsky.social + more provide insights on #BP Timely @amjhypertension.bsky.social State of Art Review #AI to improve #BP Control academic.oup.com/ajh/article-ab…

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Harriette Van Spall MD MPH 🇨🇦 @hvanspall.bsky.social · 29/04/2025

Today, we voted to protect our #sovereignty, freedom, environment, economy, people, We voted for knowledge, alliances, respect, strength, unity We voted to care about those with less so that every kid has a chance to build #CanadaStrong #ViveLeCanada #April2025

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Harriette Van Spall MD MPH 🇨🇦 @hvanspall.bsky.social · 28/04/2025

Canadians go to #polls today Counting on us to elect a strategic, steady leader who will protect #Canada’s - sovereignty - environment - economy - education - healthcare - global alliances Counting on us to reject politics of anger, fear, division #TrueNorth #CanadaStrong

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Harriette Van Spall MD MPH 🇨🇦 @hvanspall.bsky.social · 24/04/2025

Happy #AdministrativeProfessionalsDay, dear Robin Thank you making magic happen in my professional life & in our program every day Thank you for being a caring friend in the truest sense of the word Thank you for being incredibly kind to our patients I’m so #grateful for you

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Harriette Van Spall MD MPH 🇨🇦 @hvanspall.bsky.social · 21/04/2025

I voted on #EasterSunday for - A builder of #bridges, not walls - A strong #economy - Strategic international #partnerships - Environmental #sustainability - Data-informed #policy - #Education & #healthcare for all - #Respect for all Did you #vote?🇨🇦 #CanadaStrong #CanadaElection2025

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Reposted by Harriette Van Spall MD MPH 🇨🇦

Brendon Neuen @brendonneuen.bsky.social · 21/04/2025

New in CJASN: Our meta-analysis of 66 CKD trials shows both acute & chronic GFR slope independently predict clinical outcomes Findings support 3-year total slope as the optimal surrogate endpoint for CKD trials @asnpublications.bsky.social: doi.org/10.2215/CJN....

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Harriette Van Spall MD MPH 🇨🇦 @hvanspall.bsky.social · 19/04/2025

Thank you, Sharath. Sending joyful spring wishes your way.

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Harriette Van Spall MD MPH 🇨🇦 @hvanspall.bsky.social · 19/04/2025

“Let everything you do be done with love.” - 1 Corinthians Happy Easter from my home to yours! #Easter2025

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Reposted by Harriette Van Spall MD MPH 🇨🇦

Max Kozlov @maxkozlov.bsky.social · 18/04/2025

Per source, NIH has been instructed to hold off from issuing ALL awards to Harvard, Cornell, Columbia, Brown, and Northwestern (including med schools) Agency staff have also been instructed to not speak about this funding freeze to grantees and applicants

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Harriette Van Spall MD MPH 🇨🇦 @hvanspall.bsky.social · 19/04/2025

I saw the letter yesterday and was not able to confirm its authenticity. But wouldn’t surprise me if it was.

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Harriette Van Spall MD MPH 🇨🇦 @hvanspall.bsky.social · 18/04/2025

Was honoured to talk to Dr Joseph Hill, EIC of Circulation @ahajournals.bsky.social about his career path, our era of medical disinformation, & power of effective scientific #communication. Brilliant, accomplished, honest, humble, he’s among the best of the best! #Publishing tinyurl.com/2sdsuk7h

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Harriette Van Spall MD MPH 🇨🇦 @hvanspall.bsky.social · 17/04/2025

The #TarteAuChocolat was delicious, but the note was even sweeter! I never take our privilege for granted. #Cardiology #Medicine #Chocolate

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Harriette Van Spall MD MPH 🇨🇦 @hvanspall.bsky.social · 17/04/2025

No idea, friend. Interesting to watch how scientific / academic / professional organizations respond.

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Harriette Van Spall MD MPH 🇨🇦 @hvanspall.bsky.social · 16/04/2025

New 2025 #CONSORT guidelines for #RCT #reporting standards The 30 checklist items ensure transparent reporting, but adherence is suboptimal & only required by some journals (onlinelibrary.wiley.com/doi/10.1002/ej…) Essential for trialists + editorial/review teams!www.bmj.com/content/389/...23

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Harriette Van Spall MD MPH 🇨🇦 @hvanspall.bsky.social · 13/04/2025

A moment of forced truth from someone who has zero credibility and who will assume an anti-MMR stance again soon (if he hasn’t already).

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