Chen et al. identify two distinct antigen-presenting cancer-associated fibroblast (apCAF) populations across multiple cancer types. Mesothelial-related apCAFs locate near cancer cells while fibrocyte-...

Petition to Reverse the NIH Indirect Cost Cap (NOT-OD-25-068)

Abstract. Components of normal tissue architecture serve as barriers to tumor progression. Inflammatory and wound-healing programs are requisite features of solid tumorigenesis, wherein alterations to...

Cancer-associated fibroblasts (CAFs) are abundant components of the tumor microenvironment (TME) of most solid malignancies and have emerged as key re…

KEAP1 promotes persistent T cell immunity and a stem-like T cell response during chronic antigen stimulation by repressing NRF2.

A genetic screen uncovers the Fanconi anemia pathway as a driver of chromothripsis by shattering under-replicated micronuclear chromosomes during mitosis. This process involves chromosome-scale cleava...

Recent studies have identified a unique subtype of cancer-associated fibroblasts (CAFs) termed antig