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Houseley Lab

@houseleylab.bsky.social
173 followers 189 following 32 posts

We study molecular mechanisms of ageing and adaptation. Babraham Institute, Cambridge, UK. Main funding BBSRC, Wellcome Views are our own.

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Reposted by Houseley Lab
PomBase: The S. pombe knowledgebase @pombase.bsky.social · 20/08/2026
Treat biological databases as infrastructure, not projects www.nature.com/articles/d41... We're quietly defunding the infrastructure modern biology runs on. PomBase, FlyBase, HGNC. have faced, or facing, existential funding crises since 2024. Curation expertise, once lost, is difficult to rebuild.
nature.com
Treat biological databases as infrastructure, not projects
Letter to the Editor
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Houseley Lab @houseleylab.bsky.social · 03/08/2026
Great work lead by Hanane Hadj-Moussa and Megan Ulusan Babraham Institute @babrahaminst.bsky.social #BBSRC @ukri.org
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Houseley Lab @houseleylab.bsky.social · 03/08/2026
AMPK orchestrates responses to low nutrient availability from yeast to humans… …including the regulation of fatty acid synthesis through phosphorylation of the same enzyme (ACC1) This highly conserved regulatory system presents a promising target for healthy ageing research across Eukaryotes
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Houseley Lab @houseleylab.bsky.social · 03/08/2026
Controlling Acetyl coenzyme A availability underlies all these effects Acetyl coenzyme A is the building block for fatty acids but excess acetyl coenzyme A availability seems to be detrimental A2A cells make the fatty acid they need but get rid of excess acetyl coenzyme A into mitochondria
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Houseley Lab @houseleylab.bsky.social · 03/08/2026
But AMPK activation turns off fatty acid production, which is a problem Our A2A mutant combines AMPK activation with a mutation that allows continued fatty acid synthesis The majority of A2A cells maintain fitness very late in life even though they don't live any longer
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Houseley Lab @houseleylab.bsky.social · 03/08/2026
AMPK activity is widely considered to be beneficial for ageing health We show that AMPK activation in budding yeast allows some cells to age without senescence on a normal diet
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Houseley Lab @houseleylab.bsky.social · 03/08/2026
Is healthy ageing possible on a normal diet? Our new eLIFE paper describes metabolic re-engineering of yeast to avoid senescence The A2A mutant we created is super-fit late in life even on a rich high glucose diet… these cells stay healthy until they die! elifesciences.org/articles/111...
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Reposted by Houseley Lab
Mirre Simons @mirresimons.bsky.social · 18/07/2026
Latest paper: link.springer.com/article/10.1...
link.springer.com
Dietary restriction is evolutionary conserved on the phenotypic and mechanistic level - EMBO Reports
The anti-ageing response to Dietary Restriction (DR) is thought to be mechanistically ancient, reasoning from its phenotypic conservation. However, DR is implemented differently across species and evi...
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Reposted by Houseley Lab
Nitika Taneja @TanejaLab @nitikataneja.bsky.social · 01/07/2026
Very excited to share our new Nature study! We discovered that replication stress stabilizes CTCF-dependent chromatin loops enclosing stressed nascent DNA, where G9a-mediated heterochromatin protects it from nucleolytic degradation. rdcu.be/frzLg Huge thanks to all our collaborators and co-authors!
nature.com
Replication-stress-induced chromatin loops protect fork stability - Nature
Replication stress induces the formation of transient chromatin loops that enclose de novo heterochromatin-enriched stalled replication forks.
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Houseley Lab @houseleylab.bsky.social · 22/06/2026
Great work @babrahaminst.bsky.social from Kieron May on a tough project requiring some really tricky cell culture! Thanks to our collaborators at AZ and our funders: BBSRC and @astra-zeneca.bsky.social
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Houseley Lab @houseleylab.bsky.social · 22/06/2026
Ongoing DNA repair is evidenced by formation rate and size of extrachromosomal circular DNA (ecDNA) formation, revealed by a low cell ecDNA sequencing assay
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Houseley Lab @houseleylab.bsky.social · 22/06/2026
DNA damage and aberrant chromosome segregation are common in drug treated cells, which we suggest are the mechanistic source of the resistance mutations
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Houseley Lab @houseleylab.bsky.social · 22/06/2026
#TrAEL-seq shows that the DNA replication pattern is profoundly aberrant in drug-treated cells
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Houseley Lab @houseleylab.bsky.social · 22/06/2026
We show that cells frequently replicate in this Drug Tolerant Persister state Blocking S phase entry leads to complete cell death and prevents resistance
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Houseley Lab @houseleylab.bsky.social · 22/06/2026
#EGFR inhibitor osimertinib is the current standard of care for #NSCLC but resistance always emerges In culture some cells survive in a non-proliferative Drug Tolerant Persister (#DTP) state Drug resistant clones suddenly appear after months of treatment
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Houseley Lab @houseleylab.bsky.social · 22/06/2026
New preprint: Cells surviving #osimertinib frequently enter a defective S phase with DNA replication and segregation errors Preventing S phase avoids emergence of #drug resistance Great work from Kieron May Collaboration with Matt Martin @astra-zeneca.bsky.social www.biorxiv.org/content/10.6...
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Houseley Lab @houseleylab.bsky.social · 21/06/2026
Can anyone tell me why BlueSky (running in Firefox) crops images to be square when I am composing my post? The images display properly when I actually post them, but it makes it really hard to see what my post will look like...
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Reposted by Houseley Lab
Vincent van Unen @vincentvanunen.bsky.social · 19/06/2026
I am still kinda new on BlueSky. Interested in #IBD, #Tcells, #TCR ? I would kindly appreciate Reposts! :-) insight.jci.org/articles/vie...
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Reposted by Houseley Lab
British Society for Research on Ageing @bsrageing.bsky.social · 19/06/2026
Interested in submitting for #BSRA 2026, our 75th annual meeting? Link here - bsra.org.uk/events/75th-...
bsra.org.uk
75th Annual Scientific Meeting of the BSRA (2026): The Biology of Ageing - BSRA
BRITAIN’S LEADING AGEING RESEARCH CONFERENCE In 2026, the BSRA is pleased to host its 75th Annual Scientific Meeting on the Biology of Ageing at the University of Oxford between 9th and 11th September...
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Reposted by Houseley Lab
Hiten Madhani @hitenmadhani.bsky.social · 13/06/2026
A strong hint from human genetics that changes in DNA methylation may be causal for normal aging. This is the direction that aging (and cancer) research needs to go! www.nature.com/articles/s41...
nature.com
A progeria syndrome links DNA hypermethylation to age-related pathology - Nature Genetics
This study investigates the consequences of hypermethylation in a progeria syndrome caused by gain-of-function DNMT3A mutations, finding effects on adult stem cell function.
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Reposted by Houseley Lab
Peter Ly @peterlylab.bsky.social · 19/05/2026
Excited to share our latest paper! We found that large pieces of the human genome can transfer between cells upon direct contact, endowing recipient cells with heritable phenotypic changes. @cp-cell.bsky.social (1/7) www.cell.com/cell/fulltex...
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Reposted by Houseley Lab
Mirre Simons @mirresimons.bsky.social · 30/04/2026
Latest paper. We studied ATF4 in ageing in the fly. We find in contrast to previous suggestions that ATF4 suppression rather than activation extends lifespan. The study was largely conducted in an MSc project by Miriam Götz who showed an exceptional drive for science. www.pnas.org/doi/10.1073/...
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Reposted by Houseley Lab
British Society for Research on Ageing @bsrageing.bsky.social · 27/04/2026
The UK is one of only five of the richest 21 countries to see HLE decline. @ONS reports that healthy life expectancy is falling. BSRA advocates for increased funding in ageing research so we can all live healthier for longer. Dataset in the comments 👇 www.bbc.co.uk/news/article...
bbc.co.uk
UK healthy life expectancy falls by two years in past decade
Poor housing, obesity and the effects of deprivation have been suggested as underlying cause.
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Reposted by Houseley Lab
British Society for Research on Ageing @bsrageing.bsky.social · 22/04/2026
Travel Grants for #BSRA2026!!! Don't forget there is a seperate travel grant call *just* for BSRA 2026, our 75th annual meeting. This year in Oxford, it's promising to be a great meeting. bsra.org.uk/grants/ Like and share, or tag someone who should apply below👇
bsra.org.uk
Grants - BSRA
Grants We are pleased to announce an additional grant call for 2026, for Travel Grants to attend our 75th ASM in Oxford from 9-11 September. CALL NOW OPEN. Closing date 1st May 2026. More details here...
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Reposted by Houseley Lab
@MorieLAB @morielab.bsky.social · 08/04/2026
Tardigrades resist heavy DNA damage by actively repairing such lesions & expressing DNA-protective proteins. Yet, they are not immortal. How & why do they die? @morielab.bsky.social now shows that their Achilles' heel is DNA replication: duplicating your DNA... will kill you doi.org/10.1111/febs...
doi.org
FEBS Press
DNA damage in the tardigrade Hypsibius exemplaris elicits distinct cellular outcomes depending on replication status. While non-replicating cells tolerate genotoxic stress, constitutively replicating...
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Houseley Lab @houseleylab.bsky.social · 19/03/2026
6-way multiplexing at the first step allows 10-20 libraries to be made in parallel Great work Neesha and thanks to our collaborators and our funders
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Houseley Lab @houseleylab.bsky.social · 19/03/2026
TrAEL-seq read density reflects the speed or replication forks, allowing quantification of interactions with genomic elements such as transcription
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Houseley Lab @houseleylab.bsky.social · 19/03/2026
TrAEL-seq profiles rival quality to OK-seq but are much easier to generate
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Houseley Lab @houseleylab.bsky.social · 19/03/2026
Need to profile DNA replication genome-wide? TrAEL-seq reveals replication patterns and fork progression in unsynchronised, unlabelled and unsorted cells Our revised protocol: • Provides far better data from mammalian cells • Includes 6-way multiplexing academic.oup.com/nar/article/...
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Houseley Lab @houseleylab.bsky.social · 12/03/2026
Exciting new project in our lab @babrahaminst.bsky.social! We are working with @alesdantas.bsky.social at @newcastleuni.bsky.social to understand how extrachromosomal circular DNA mediates drug resistance in fungal pathogens Funded by @wellcometrust.bsky.social #ecDNA #eccDNA #Candida #Zymoseptoria
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Houseley Lab @houseleylab.bsky.social · 04/02/2026
Post-doc job alert! Only a week left to apply for this post doc role, joining our team at the Babraham Institute @babrahaminst.bsky.social to explore ageing metabolism and epigenetics. babrahaminstitute.livevacancies.co.uk#/job/details...
babrahaminstitute.livevacancies.co.uk
hireful.
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Houseley Lab @houseleylab.bsky.social · 19/01/2026
Post-doc job alert! We have an exciting opportunity for a post doc to join our team at the Babraham Institute, exploring ageing metabolism and epigenetics. babrahaminstitute.livevacancies.co.uk#/job/details...
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Houseley Lab @houseleylab.bsky.social · 11/06/2025
6-way multiplexing at the first step allows 10-20 libraries to be made in parallel Great work Neesha and thanks to our collaborators and our funders
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Houseley Lab @houseleylab.bsky.social · 11/06/2025
TrAEL-seq read density reflects the speed or replication forks, allowing quantification of interactions with genomic elements such as transcription
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Houseley Lab @houseleylab.bsky.social · 11/06/2025
Our new Preprint describes an improved TrAEL-seq protocol: • Provides far better data from mammalian cells • Includes multiplexing for higher throughput TrAEL-seq reveals replication patterns and fork progression in unsynchronised, unlabelled and unsorted cells www.biorxiv.org/content/10.1...
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Houseley Lab @houseleylab.bsky.social · 12/05/2025
If you're at the AGE meeting don't miss the BSRA Korenchevsky Award talk from Hanane Hadj-Moussa! Hanane's work shows that we can acheive excellent healthy ageing through metabolic rewiring, even on an unrestricted diet Profile: whova.com/embedded/spe... Preprint: www.biorxiv.org/content/10.1...
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Houseley Lab @houseleylab.bsky.social · 28/03/2025
Great work lead by Hanane Hadj-Moussa and Megan Ulusan Babraham Institute @babrahaminst.bsky.social #BBSRC @ukri.org
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Houseley Lab @houseleylab.bsky.social · 28/03/2025
AMPK orchestrates responses to low nutrient availability from yeast to humans… …including regulation of fatty acid synthesis through phosphorylation of the same enzyme This highly conserved regulatory system presents a promising and unexplored target for healthy ageing research across Eukaryotes
100
Houseley Lab @houseleylab.bsky.social · 28/03/2025
Controlling Acetyl coenzyme A availability underlies all these effects Acetyl coenzyme A is the building block for fatty acids but excess acetyl coenzyme A availability is detrimental A2A cells make the fatty acid they need but get rid of excess acetyl coenzyme A into mitochondria
110
Houseley Lab @houseleylab.bsky.social · 28/03/2025
but AMPK activation turns off fatty acid production, which is a problem Our A2A mutant combines AMPK activation with a mutation that allows continued fatty acid synthesis The majority of A2A cells maintain fitness very late in life even though they don't live any longer
100
Houseley Lab @houseleylab.bsky.social · 28/03/2025
AMPK activity is widely considered to be beneficial for ageing health We show that AMPK activation in budding yeast allows some cells to age without senescence on a normal diet...
100
Houseley Lab @houseleylab.bsky.social · 28/03/2025
Is healthy ageing possible on a normal diet? Our latest Preprint describes metabolic re-engineering of yeast to avoid senescence The A2A mutant we created is super-fit late in life even on a rich high glucose diet www.biorxiv.org/content/10.1...
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Houseley Lab @houseleylab.bsky.social · 21/03/2025
Congratulations to our PhD student Amy Wolstenholme for winning the Poster Prize at the EMBL Drug Resistance meeting #EESDrugResistance this week Amy's poster showed that circular DNAs providing copper resistance can be stably transmitted for hundreds of generations in yeast
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