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Harlan M. Krumholz

@hmkyale.bsky.social
2K followers 8 following 95 posts

Committed to my family, friends, and colleagues - working to make the future better than the past.

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Harlan M. Krumholz @hmkyale.bsky.social · 01/10/2026
Search engines gave patients documents. LLMs give them an interpretation and a plan. The information asymmetry that reinforced the physician's authority is eroding. Where that leaves physicians, in my Editor's Page (free to read): www.jacc.org/doi/10.1016/... @jaccjournals.bsky.social
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Harlan M. Krumholz @hmkyale.bsky.social · 10/06/2026
I've authored quality measures for 30+ years. My new @jaccjournals.bsky.social Editor's Page: what we built mattered — but it hasn't done enough. We now have the tools to build something better. To assist and improve. www.jacc.org/doi/10.1016/...
jacc.org
Seeing and Improving Care: The Next Frontier of Quality Measurement
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Yale Cancer Center @yalecancer.bsky.social · 13/03/2026
Dr. Kevin Billingsley joined the 'Health & Veritas' podcast to talk about how #robotics and advanced imaging are reshaping what it means to be a surgeon. insights.som.yale.edu/podcasts/hea... @yalesom.bsky.social @yalesph.bsky.social @thehowie.bsky.social @hmkyale.bsky.social #healthandveritas
insights.som.yale.edu
Kevin Billingsley: The Making of the Modern Surgeon
Howie and Harlan are joined by Yale School of Medicine surgical oncologist Kevin Billingsley, who discusses how robotics and advanced imaging are reshaping what it means to be a surgeon and offers gui...
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Solomon Center @ YLS @solomonctryls.bsky.social · 23/04/2026
On the new episode of #HealthandVeritas, Solomon Center affiliated faculty @thehowie.bsky.social and co-host @hmkyale.bsky.social speak with Dr. Stephen Latham about why the legal definition of death is becoming less useful as medical technologies progress. som.yale.edu/podcasts/hea...
som.yale.edu
Stephen Latham: The End of Irreversibility
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Reposted by Harlan M. Krumholz
Richard Sever @richardsever.bsky.social · 07/05/2026
The vaccine safety study that did not disappear - @hmkyale.bsky.social on the medRxiv paper the FDA has reportedly blocked formal publication of neverdelegateunderstanding.substack.com/p/the-vaccin...
neverdelegateunderstanding.substack.com
The Vaccine Safety Study That Did Not Disappear
Whatever the findings, government-commissioned research should be published
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Harlan M. Krumholz @hmkyale.bsky.social · 08/05/2026
My dear 92-year-old mother-in-law did not survive her heart attack. The CCU team showed our family what cardiology at its best looks like, and it wasn't the technology. My @jaccjournals.bsky.social Editor's Page on the experience: www.jacc.org/doi/10.1016/...
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Harlan M. Krumholz @hmkyale.bsky.social · 17/02/2026
And here is an interview with Sarah. We reflect on how the culture and structure of cardiology shape the experiences of women in training and practice. @jaccjournals.bsky.social www.jacc.org/digital-cont...
jacc.org
Podcast Episode: JACC This Week Bonus Episode – Women’s Cardiovascular Health: From Inclusion to Redesign
This bonus episode continues the conversation from the JACC Women’s Cardiovascular Health Issue, moving from science to systems. In this extended discussion, Drs. Carolyn Lam and Harlan Krumholz are joined by Sarah Krumholz to reflect on how the culture and structure of cardiology shape the experiences of women in training and practice.
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Harlan M. Krumholz @hmkyale.bsky.social · 17/02/2026
Proud moment. My daughter’s Heartbeats essay at JACC, “Dueling Pursuits: Balancing Motherhood and Medicine,” reflects on pregnancy during med school and the structural barriers women continue to face. Honest, thoughtful, and important. @jaccjournals.bsky.social authors.elsevier.com/a/1mdcc_GjkR...
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Harlan M. Krumholz @hmkyale.bsky.social · 14/01/2026
New Health & Veritas bonus episode with Ania Jastreboff, coinciding with the release of Enough: Your Health, Your Weight, and What It’s Like to Be Free (with Oprah Winfrey). “Having obesity is not a choice. It’s driven by biology.” @thehowie.bsky.social 🎧 insights.som.yale.edu/podcasts/hea...
insights.som.yale.edu
Ania Jastreboff: Treating Obesity Without Shame
In this bonus episode, Howie and Harlan are joined by Ania Jastreboff, a Yale School of Medicine endocrinologist and an expert on the science of obesity. They discuss her new book, co-authored with Op...
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Harlan M. Krumholz @hmkyale.bsky.social · 06/01/2026
“Older adults were, and still are, at the center of cardiovascular care, but they remain on the margins of cardiovascular science.” My Editor’s Page in the new @JACCJournals issue reflects on why this gap persists, and what must change. www.jacc.org/doi/10.1016/...
jacc.org
Older Patients and Cardiovascular Disease: At the Center of Care, on the Margins of Science
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Harlan M. Krumholz @hmkyale.bsky.social · 06/01/2026
New JACC issue centers on cardiovascular care for older adults: • Frailty and BP control • Frailty as a prognostic tool in HF • Loss of Y chromosome and CV risk • Vascular cognitive impairment and dementia Age is not the whole story. 👉 JACC.org @jaccjournals.bsky.social
jacc.org
JACC Journals Exploring the Impact on Cardiovascular Medicine
Stay informed with JACC Family of Journals, published by the ACC | Providing updates in cardiovascular medicine for clinicians, specialists, and researchers.
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Harlan M. Krumholz @hmkyale.bsky.social · 06/01/2026
“The goal isn’t just to live longer, it’s to live better.” — Ezekiel Emanuel New Health & Veritas bonus episode 🎙️ insights.som.yale.edu/podcasts/hea...
insights.som.yale.edu
Ezekiel Emanuel: Ice Cream and Other Keys to a Long Life
In a bonus episode, Howie and Harlan welcome oncologist, bioethicist, and public health expert Ezekiel Emanuel to discuss his new book, which counters the wellness industry by offering simple, evidenc...
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Harlan M. Krumholz @hmkyale.bsky.social · 06/01/2026
“If wellness requires constant self-denial, it won’t last.” — Ezekiel Emanuel Why eating your ice cream might actually be part of a healthy life. 🎧 Health & Veritas bonus episode insights.som.yale.edu/podcasts/hea...
insights.som.yale.edu
Ezekiel Emanuel: Ice Cream and Other Keys to a Long Life
In a bonus episode, Howie and Harlan welcome oncologist, bioethicist, and public health expert Ezekiel Emanuel to discuss his new book, which counters the wellness industry by offering simple, evidenc...
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Harlan M. Krumholz @hmkyale.bsky.social · 06/01/2026
“Having friends is better for your immune system and your heart than most people realize.” — Ezekiel Emanuel Bonus episode of Health & Veritas 🎙️ 🎧 insights.som.yale.edu/podcasts/hea...
insights.som.yale.edu
Ezekiel Emanuel: Ice Cream and Other Keys to a Long Life
In a bonus episode, Howie and Harlan welcome oncologist, bioethicist, and public health expert Ezekiel Emanuel to discuss his new book, which counters the wellness industry by offering simple, evidenc...
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Harlan M. Krumholz @hmkyale.bsky.social · 06/01/2026
“Wellness shouldn’t feel like self-denial.” — Ezekiel Emanuel A bonus episode of Health & Veritas on longevity, joy, and what the evidence really says. 🎧 insights.som.yale.edu/podcasts/hea...
insights.som.yale.edu
Ezekiel Emanuel: Ice Cream and Other Keys to a Long Life
In a bonus episode, Howie and Harlan welcome oncologist, bioethicist, and public health expert Ezekiel Emanuel to discuss his new book, which counters the wellness industry by offering simple, evidenc...
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Harlan M. Krumholz @hmkyale.bsky.social · 06/01/2026
🎙️Bonus episode of Health & Veritas In this special episode, we talk w/Ezekiel Emanuel about his new book Eat Your Ice Cream, why wellness should not feel like punishment, and how evidence can support a life that includes joy. @thehowie.bsky.social Listen here 👉 insights.som.yale.edu/podcasts/hea...
insights.som.yale.edu
Ezekiel Emanuel: Ice Cream and Other Keys to a Long Life
In a bonus episode, Howie and Harlan welcome oncologist, bioethicist, and public health expert Ezekiel Emanuel to discuss his new book, which counters the wellness industry by offering simple, evidenc...
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Harlan M. Krumholz @hmkyale.bsky.social · 02/01/2026
The Dry January Experiment: What happens to your blood pressure after just one less drink? Evidence from @jaccjournals.bsky.social suggests even light drinking affects your heart health. @yaleschoolofmed.bsky.social @yalesph.bsky.social 👉 neverdelegateunderstanding.substack.com/p/the-dry-ja...
neverdelegateunderstanding.substack.com
The Dry January Experiment
What Happens to Your Blood Pressure After Just One Less Drink?
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Harlan M. Krumholz @hmkyale.bsky.social · 11/12/2025
Do clinical trials expire? New heart attack studies show that evidence from 1980s may not apply to patients in 2025. Beta blockers are a case study in how medicine evolves, and how slowly our evidence base often keeps up. My latest Substack: neverdelegateunderstanding.substack.com/p/do-clinica...
neverdelegateunderstanding.substack.com
Do Clinical Trials Expire?
What Beta Blockers Teach Us About How Medicine Learns
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Harlan M. Krumholz @hmkyale.bsky.social · 11/11/2025
After two years and thousands of manuscripts, I’ve learned that the real work of an editor isn’t gatekeeping — it’s partnership. My latest JACC Editor’s Page: The Partnership 🔗 www.jacc.org/doi/10.1016/... #MedTwitter #AcademicMedicine #Cardiology
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Harlan M. Krumholz @hmkyale.bsky.social · 13/10/2025
And be sure to check out our Adipokine Explorer! www.jacc.org/jacc/interac...
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Harlan M. Krumholz @hmkyale.bsky.social · 13/10/2025
Here is my substack on the topic: Fat, Reframed. neverdelegateunderstanding.substack.com/p/fat-reframed
neverdelegateunderstanding.substack.com
Fat, Reframed
A Turning Point in Heart Disease
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Harlan M. Krumholz @hmkyale.bsky.social · 13/10/2025
@jaccjournals.bsky.social is the place for ideas that may change our thinking; spark dialogue; and contribute to progress in advancing global cardiovascular health.
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Harlan M. Krumholz @hmkyale.bsky.social · 13/10/2025
HFpEF is one of medicine’s biggest puzzles. Maybe the answers lie not in the heart alone, but in the cross-talk between fat and myocardium. Read the full JACC Adipokine Spotlight and join the conversation. 🔗 www.jacc.org/toc/jacc/cur... #JACC #HFpEF #Cardiology #AdipokineHypothesis
jacc.org
JACC: Vol 86, No 16
JACC. 2025 Oct, 86 (16) 1231–1233.
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Harlan M. Krumholz @hmkyale.bsky.social · 13/10/2025
The issue invites disagreement and testing. Some cases of HFpEF may not fit the model. But frameworks like this push the field forward—helping us ask sharper questions and design better studies.
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Harlan M. Krumholz @hmkyale.bsky.social · 13/10/2025
Themes emerge: • It’s about fat distribution, not just BMI. • Adipokines act through endocrine-paracrine signaling. • Sex, race, and metabolic context all shape expression and risk. • New therapies (GLP-1RA, SGLT2i) may restore adipokine balance.
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Harlan M. Krumholz @hmkyale.bsky.social · 13/10/2025
To deepen the discussion, we invited experts across cardiology and metabolism to weigh in: • Erica Spatz: A Turning Point • Carolyn Lam & Dalane Kitzman: From Pariah to Paradigm • Subodh Verma & Deepak Bhatt: Parsing the Adipokine Axis • Faiez Zannad, Jennifer Ho, Robert Mentz, and others.
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Harlan M. Krumholz @hmkyale.bsky.social · 13/10/2025
As Editor-in-Chief, I wrote about why JACC published it: Because progress in medicine requires ideas that connect disciplines and challenge assumptions. 🧠 “Ideas Worth Testing: The Adipokine Hypothesis.” www.jacc.org/doi/10.1016/...
jacc.org
Ideas Worth Testing: The Adipokine Hypothesis
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Harlan M. Krumholz @hmkyale.bsky.social · 13/10/2025
In this 25,000-word State-of-the-Art Review, Packer unites >1,800 references to build a testable framework explaining how dysfunctional adipose tissue could underlie HFpEF. It’s bold, ambitious—and worth debating.
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Harlan M. Krumholz @hmkyale.bsky.social · 13/10/2025
Dr. Milton Packer proposes that hypertrophied, inflamed fat cells secrete molecules—adipokines—that drive cardiac remodeling, inflammation, and fibrosis. In other words: HFpEF may begin in fat, not the heart.
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Harlan M. Krumholz @hmkyale.bsky.social · 13/10/2025
After decades of disappointment in HFpEF, a new idea is shaking things up. Could heart failure with preserved EF actually be an adipose-driven disease? JACC’s latest issue explores “The Adipokine Hypothesis.” @jaccjournals.bsky.social 🔗 www.jacc.org/toc/jacc/cur...
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Harlan M. Krumholz @hmkyale.bsky.social · 06/10/2025
Physician certification should not be an ordeal; it is in vast need of improvement. My @jaccjournals.bsky.social Journals Editor’s Page explores how we can modernize physician certification to be relevant, humane, and effective. 🔗 www.jacc.org/doi/10.1016/...
jacc.org
Rethinking Physician Certification: A Call for a Modern, Meaningful Standard
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Harlan M. Krumholz @hmkyale.bsky.social · 29/09/2025
In this Editor’s Page, I outline why we believe authors can use AI tools to improve scientific writing—if they fully own what they submit. At JACC, we won’t stigmatize responsible use of AI. But we will insist on accountability. jacc.org/doi/10.1016/... @jaccjournals.bsky.social
jacc.org
Tools, Not Ghosts: Artificial Intelligence, Writing, and Responsibility
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Harlan M. Krumholz @hmkyale.bsky.social · 29/09/2025
In this Editor’s Page, I outline why we believe authors can use AI tools to improve scientific writing if they fully own what they submit. At JACC,we won’t stigmatize responsible use of AI. We will insist on accountability. www.jacc.org/doi/10.1016/... @jaccjournals.bsky.social @yalemed.bsky.social
jacc.org
Tools, Not Ghosts: Artificial Intelligence, Writing, and Responsibility
Download article citation: If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download.
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Harlan M. Krumholz @hmkyale.bsky.social · 29/09/2025
For anyone who has wanted a clear, authoritative summary of inflammation and cardiovascular disease, and where the science is heading, here it is. The 2025 ACC Scientific Statement on Inflammation and Cardiovascular Disease. @jaccjournals.bsky.social www.jacc.org/doi/10.1016/...
jacc.org
Inflammation and Cardiovascular Disease: 2025 ACC Scientific Statement: A Report of the American College of Cardiology
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Harlan M. Krumholz @hmkyale.bsky.social · 28/09/2025
This is an extraordinary report from @ihmeuw.bsky.social and published in @jaccjournals.bsky.social; it demonstrates that cardiovascular disease is a global scourge. And we are failing to leverage what we know to save lives. www.jacc.org/doi/10.1016/...
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Tim Plante, MD MHS @tbplante.bsky.social · 25/09/2025
Congratulations to @uvmlarnermed.bsky.social medical student, Sarah Krumholz, for winning the Outstanding Research Publication award for her study in REGARDS investigating risk of hypertension by sRAGE level! Very well deserved! Her paper: pubmed.ncbi.nlm.nih.gov/40708351/
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Harlan M. Krumholz @hmkyale.bsky.social · 23/09/2025
The next leap is computable quality. Living, real-time intelligence from routine clinical data that will: -Support accountability -Fuel improvement -Accelerate discovery
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Harlan M. Krumholz @hmkyale.bsky.social · 23/09/2025
But most current measures fail this test. Registries = richer than claims but costly, delayed, and not built for improvement Claims = coarser, even more delayed Neither delivers what clinicians need at the point of care.
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Harlan M. Krumholz @hmkyale.bsky.social · 23/09/2025
Door-to-balloon time proved what’s possible. When hospitals had real-time feedback, mortality for STEMI dropped—without new drugs or devices. The lesson? 👉 Quality improves when data are timely, trusted, and actionable.
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Harlan M. Krumholz @hmkyale.bsky.social · 23/09/2025
Quality measurement was once a breakthrough. But today it’s too slow, too costly, and too disconnected from daily care. It’s time to reinvent it. 🆕 My Editor’s Page in JACC: www.jacc.org/doi/epdf/10.... @jaccjournals.bsky.social @yalemed.bsky.social
jacc.org
Computable Quality
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Miranda Shafer @mirandashafer.bsky.social · 11/09/2025
“Everyone thinks their genes are the cause for them getting an age-related disease, it’s actually your immune system.” - @erictopol.bsky.social the author of Super Agers on #HealthandVeritas podcast pod.link/1588414491/e... @thehowie.bsky.social @hmkyale.bsky.social
pod.link
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Eric Topol @erictopol.bsky.social · 12/09/2025
A conversation on Healthy Aging with @hmkyale.bsky.social and @thehowie.bsky.social @yaleschoolofmed.bsky.social insights.som.yale.edu/podcasts/hea...
insights.som.yale.edu
Eric Topol: The Keys to Healthy Aging
Howie and Harlan are joined by physician, scientist, and author Eric Topol to discuss his new book, Super Agers: An Evidence-Based Approach to Longevity; the potential of individualized polygenic risk...
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Harlan M. Krumholz @hmkyale.bsky.social · 16/09/2025
New @JACCJournals: Guiding the AI Revolution in CV Medicine I lay out 5 operational principles—from rigorous validation to bias reduction—to make AI safe, equitable & impactful in cardiology. ➡️ www.jacc.org/doi/10.1016/... @jaccjournals.bsky.social @yalemed.bsky.social @yaleschoolofmed.bsky.social
jacc.org
Guiding the AI Revolution in Cardiovascular Medicine:
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Harlan M. Krumholz @hmkyale.bsky.social · 01/09/2025
Biology, not blame. That’s the message from #ESCCongress. Fat is not just storage, it’s an organ. Its signals may drive heart failure and more. Read my take: Fat, Reframed: A Turning Point in Heart Disease. substack.com/home/post/p-... @jaccjournals.bsky.social @yaleschoolofmed.bsky.social
substack.com
Fat, Reframed
A Turning Point in Heart Disease
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Reposted by Harlan M. Krumholz
snigdhajain.bsky.social @snigdhajain.bsky.social · 27/08/2025
1/4 Rehabilitation can ⬆️ Functional Independence and ⬇️ Long-term Cognitive Impairment among #ICU survivors. But how often do hospitals deliver it? Led by @yalemedicine.bsky.social resident Jose Victor, our paper bit.ly/41p9fPT in @accpchest.bsky.social provides insights
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Harlan M. Krumholz @hmkyale.bsky.social · 25/08/2025
New @JACCJournals Editor’s Page: A Disquieting Plateau 🫀 Cardiovascular mortality progress has stalled 📉 In some areas, it’s reversing 💡 We must confront what’s happening on our watch—and what comes next 👉 authors.elsevier.com/a/1lfjn2d9GI... #CardioTwitter #HealthEquity @jaccjournals.bsky.social
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Harlan M. Krumholz @hmkyale.bsky.social · 20/08/2025
In my new Substack post... Did you know air pollution can raise blood pressure? I break down a just-published JACC trial testing HEPA filters in homes near highways—and what it means for heart health. @jaccjournals.bsky.social 👉 neverdelegateunderstanding.substack.com/p/00314b6f-e...
neverdelegateunderstanding.substack.com
Never Delegate Understanding
Making health and science understandable. Click to read Never Delegate Understanding, by Harlan Krumholz, a Substack publication. Launched 3 days ago.
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Harlan M. Krumholz @hmkyale.bsky.social · 20/08/2025
Can a HEPA filter protect the heart? My latest JACC #DeepDive explores a new trial of in-home air filtration—what it found, why the effect size matters, and how it fits into decades of research on air pollution and CVD risk. 🎧 www.jacc.org/digital-cont... @jaccjournals.bsky.social
jacc.org
Podcast Episode: Environmental Exposure as Intervention: HEPA Filtration and Blood Pressure Near Traffic Corridors | JACC Deep Dive
In this Deep Dive, Editor-in-Chief Dr. Harlan Krumholz explores a pragmatic, randomized crossover trial testing whether in-home HEPA filtration can reduce blood pressure in adults living near high-traffic roadways. The findings offer early insights into how targeted environmental interventions may influence cardiovascular risk—especially among individuals with elevated baseline systolic blood pressure.
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Harlan M. Krumholz @hmkyale.bsky.social · 20/08/2025
🎙️ New JACC This Week podcast! This issue features: 🔹 CSPACE RCT — CSP vs RV pacing in AV block 🔹 HEPA filtration & blood pressure 🔹 FLAVOUR 6-year follow-up—FFR vs IVUS 🔹 Editor’s Page: excess CV mortality in Black Americans 🎧 Listen: www.jacc.org/digital-cont... @jaccjournals.bsky.social
jacc.org
Podcast Episode: Pacing Strategies, Air Quality, and the Path to Equity | JACC This Week
In this week's JACC Deep Dive podcast, Dr. Harlan Krumholz highlights new science with direct clinical implications: a randomized trial showing conduction system pacing outperforms RV pacing in AV block, a pragmatic study suggesting HEPA filtration may modestly lower blood pressure, and long-term data from FLAVOR comparing FFR and IVUS-guided PCI. Also featured are a state-of-the-art review on heart failure therapy implementation, a brief report refining NT-proBNP thresholds for pre–heart failure, and an updated JACC Report Card revealing persistent cardiovascular mortality disparities among Black Americans.
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Harlan M. Krumholz @hmkyale.bsky.social · 19/08/2025
Did COVID-19 really age our arteries? A major new study says yes—esp in women. But is it true? I take a deeper look to see if the evidence matches the headlines. Read it here → neverdelegateunderstanding.substack.com/p/did-covid-... #COVID19 @virusesimmunity.bsky.social @yalemed.bsky.social
neverdelegateunderstanding.substack.com
Did COVID Age Our Arteries?
A Closer Look at the Evidence
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