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Blood eosinophil count, FeNO, asthma attack history, disease severity, low lung function (low FEV1%), and symptoms (ACQ-5 score) are key predictors of asthma attacks. Conversely, we found that moderat...

Lymph node IL-2 microniches guide development of TH2 cells through induction of Blimp-1 expression and an IL-10–positive feedback loop.

Study on hydroxychloroquine by Didier Raoult and colleagues gets pulled on ethical and scientific grounds

Mast cells act as “signal converters,” translating immunological and tissue signals into host-protective behaviors. They sense antigen and possibly toxins driving avoidance behavior, which can prevent inflammation and tissue damage. Beyond classical immunity, mast cells rapidly activate antigen expulsion responses and initiate nociception. These reflexes promote host-protective behavior and maintain tissue integrity.

Paired long-read metagenomic sequencing and proteomics in sputum and nasal lavage identified a single dominant respiratory pathogen (H. influenzae more than M. catarrhalis and S. pneumoniae) in 23% o...