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Danfeng Cai

@danfengcai.bsky.social
57 followers 38 following 7 posts

Assistant Professor at Johns Hopkins School of Public Health studying biomolecular condensates, gene regulation, and cancer.

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Reposted by Danfeng Cai
jp flores (he/him) @jpflores.rbind.io · 22/12/2025
9/ Grateful to everyone that contributed to this work, especially the team of @danfengcai.bsky.social, Chenxi Xu and Greg Wang at Duke, Andrea Perreault at Elon, Zack Drum (now faculty at NC Central), and all of the Phanstiel Lab past and present! See ya at the defense! 😁
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Reposted by Danfeng Cai
American Association for Cancer Research (AACR) @theaacr.bsky.social · 14/01/2026
Condensates: Fact or Fusion? Danfeng Cai, Lukasz Bugaj, Natasha Caplen, Miguel Rivera, and Andrew Seeber addressed this question in a plenary session at the AACR Special Conference on Fusion-Positive Cancer. #AACRfusion26 @danfengcai.bsky.social @bugajlab.bsky.social
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Reposted by Danfeng Cai
Johns Hopkins Department of Biochemistry and Molecular Biology @johnshopkinsbmb.bsky.social · 11/06/2026
Online today @natcellbio.nature.com! The Cai Lab discovered a type of large condensate in the nucleus of renal cell carcinoma cells with high levels of the TEAD1 transcription factor that are different than previously characterized transcriptional condensates (1/3)
publichealth.jhu.edu
Discovery of Condensate ‘Storage Units’ in Cells Points to New Cancer Research and Treatment Targets | Johns Hopkins Bloomberg School of Public Health
Clusters storing gene activators near inactive regions of DNA in cell nuclei could illuminate cancer biology.
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Reposted by Danfeng Cai
Henri Niskanen @henriniskanen.bsky.social · 17/06/2025
Check out a technology feature in @nature.com by Elie Dolgin regarding our recent 'Killswitch' publication www.nature.com/articles/d41... Thank you for the comments and first impressions by Rick Young, Isaac Klein, @danfengcai.bsky.social @superscijew.bsky.social @yaotianzhang.bsky.social
nature.com
‘Killswitch’ protein lets scientists study immobilized cellular droplets
Synthetic peptide fixes biomolecular condensates, revealing how these enigmatic cell structures actually work.
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Danfeng Cai @danfengcai.bsky.social · 02/06/2025
Highlight on our recent work on TFE3 fusion translocation renal cell carcinoma
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Danfeng Cai @danfengcai.bsky.social · 17/05/2025
Our preprint is up!!
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Danfeng Cai @danfengcai.bsky.social · 16/04/2025
So happy our paper on TFE3 fusion oncoprotein condensates in translocation RCC is online at Cell Reports! Great collaboration from Eneda Toska, Vito Rebecca, Marston Linehan and Hongkai Ji labs. Proud of the work of trainees Choon Leng So, Jane Lee, Bujamin Vokshi et al www.cell.com/cell-reports...
cell.com
TFE3 fusion oncoprotein condensates drive transcriptional reprogramming and cancer progression in translocation renal cell carcinoma
So et al. investigate TFE3 fusion oncoproteins (FOs) in translocation renal cell carcinoma (tRCC) and find that TFE3 FOs form transcriptional condensates and drive tRCC progression. The structured coi...
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Danfeng Cai @danfengcai.bsky.social · 21/03/2025
Ending the week with paper acceptance. Congratulations Jane and Choon!! (A dramatic champange opening moment)
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