iiinova — where your digital self keeps evolving

Heather Lee @heatherjlee.bsky.social · 28/07/2025

Special thanks to lead authors Danielle Bond and Sean Burnard and collaborators including @charles-debock.bsky.social, @mixomics.org and colleagues @hmriaustralia.bsky.social

010

Heather Lee @heatherjlee.bsky.social · 28/07/2025

These results show that AML therapies can increase epigenetic heterogeneity with implications for #cancer growth and treatment. By targeting the processes that help AML cells to re-initiate cancer growth, we may be able to delay AML progression.

100

Heather Lee @heatherjlee.bsky.social · 28/07/2025

Genes related to #cholesterol processes had increased expression in colonies formed after HMA exposure, regardless of the colony's methylation level. Targeting these processes with #statin co-treatment increased the efficacy of HMAs.

100

Heather Lee @heatherjlee.bsky.social · 28/07/2025

We show that some AML cells can evade the #epigenetic effects of these therapies and retain #DNAmethylation. We also found that HMA exposure alters transcription, even in highly-methylated cells.

100

Reposted by Heather Lee

Mark Dawson @mafdawson.bsky.social · 12/03/2025

We are looking for a talented postdoctoral bioinformatician @thedawsonlab.bsky.social to work with us on single cell multiomics incorporating lineage tracing and spatial technologies- we specifically want someone curious, fearless with a licence to innovate!! Come join us!!

nature.com

Postdoctoral Fellow (Bioinformatics & Computational Biology) - Parkville, Melbourne (AU) job with Peter MacCallum Cancer Centre – Parkville | 12837684

Applicants are invited to join an exciting multi-discliplinary research program within Mark Dawson’s Laboratory at the Peter MacCallum Cancer Centre.

12417

Heather Lee @heatherjlee.bsky.social · 24/02/2025

@aepia.bsky.social members concerned about recent changes to US research agencies should consider following @epigeneticssociety.bsky.social and/or signing the declaration below.

030

Reposted by Heather Lee

Jamie Hackett @jamiehackett.bsky.social · 11/02/2025

Want to start an independent research group? ...with core funding, outstanding facilities & a curiosity-driven culture? Join us at @embl.org We are recruiting across research themes, inc (epi)genomics, human dev bio, predictive modelling & neurobiology👇 embl.wd103.myworkdayjobs.com/en-US/EMBL/d...

embl.wd103.myworkdayjobs.com

Group Leader - Molecular Mechanisms of Environmental Adaptation

We are seeking to recruit a highly motivated scientist to establish and lead an independent research laboratory at the EMBL Epigenetics and Neurobiology Unit in Rome. EMBL provides a unique environmen...

37750