Sign in

hcastelan.bsky.social

@hcastelan.bsky.social
240 followers 441 following 5 posts

PhD in science interested in the evolutionary dynamics of viruses, metagenomics scholar.google.es/citations?user=Hl…

PostsRepliesMedia
Reposted by @hcastelan.bsky.social
ulisdsrodriguez.bsky.social @ulisdsrodriguez.bsky.social · 24/07/2026
biorxiv.org
Phylogenetic correlation between the Type IV Secretion System and HIP1 suggest an adaptation for horizontal gene transfer conserved at the phylum level
Most cyanobacterial genomes are rich in the GCGATCGC octamer, also known as Highly Iterated Palindrome 1 (HIP1). Despite its description over three decades ago, the biological function of this highly ...
032
Reposted by @hcastelan.bsky.social
Steph N. Seifert, PhD @stephseifertphd.bsky.social · 15/06/2026
🚨 Ever wonder why some viral reassortants establish and spread while others disappear? Us too! Led by @ricardoriveroh.bsky.social, we studied drivers of viral reassortment across hantaviruses and found that it varies dramatically among lineages (1/3) Preprint: doi.org/10.64898/202...
13215
Reposted by @hcastelan.bsky.social
Sullivan Lab at OSU @sullivan-lab.bsky.social · 06/07/2026
🚨VIROMICS WORKSHOP 2026🚨 Application is now OPEN for the 8th International Viromics Workshop, Oct. 14-16, 2026, in-person at Ohio State University. Application closes Aug. 7. Apply: forms.gle/pJFLDCNEBvAe... Full details: u.osu.edu/viruslab/vir... #viromics #viruses #ecology #workshop
forms.gle
01616
Reposted by @hcastelan.bsky.social
Lambodhar Damodaran @lambod50.bsky.social · 20/04/2026
Check out the preprint of a project I had the pleasure of working on with Nicola Mueller and Louise Moncla on North American H5 reassortment! Feel free to reach out with questions or thoughts!
053
Reposted by @hcastelan.bsky.social
Asher Leeks @asherleeks.bsky.social · 14/04/2026
The Social Lives of Viruses is coming to Vancouver, Canada, from 4th-8th August 2026! This is a free meeting dedicated to all aspects of virus-virus interactions & evolution. To apply: socialviruses.zoology.ubc.ca @sociovirology.bsky.social #socialviruses #evosky #lovevirology #virosky
06146
Reposted by @hcastelan.bsky.social
Marc Veldhoen @marcveld.bsky.social · 08/05/2026
The Andes variant has been sequenced and publically shared. I leave it to virologists to dissect this first. virological.org/t/co... 1/2
virological.org
Complete sequence of Orthohantavirus andesense virus: Swiss resident 2026
Posted on behalf of the Swiss National Reference Center for Emerging Viral Infections, Geneva University Hospitals and the Institute of Medical Virology, University of Zurich (Partner Laboratory National Reference Center for Emerging Viral Infections). On 5 May 2026, the Swiss National Reference Center for Emerging Viral Infections (Geneva University Hospitals) confirmed a case of Andes strain in a Swiss resident who had travelled on the MV Hondius cruise ship. The virus was sequenced from bloo...
1166
hcastelan.bsky.social @hcastelan.bsky.social · 07/05/2026
New paper out: we recovered MAGs from hypersaline saltwater in Peru.
000
Reposted by @hcastelan.bsky.social
bioRxivpreprint @biorxivpreprint.bsky.social · 17/03/2026
Virological investigation of elephant endotheliotropic herpesvirus 1B infection in an Australian captive herd of Asian elephants (Elephas maximus) www.biorxiv.org/content/10.64898/20…
011
Reposted by @hcastelan.bsky.social
Microbiome Virtual International Forum @microbiomevif.bsky.social · 23/01/2026
It's Friday! ...and a new #MVIF program is out! 🤩 Free registration: cassyni.com/s/mvif-46 Highlights: 🇺🇸 Rebecca L. Knoll 🇯🇵 Akito Sakanaka Keynote: 🇺🇸 @simrouxvirus.bsky.social ⭐️ Talks: 🇦🇺 @jeremyjbarr.bsky.social 🇨🇦 @erikbakkeren.bsky.social 🇨🇳 Guanxiang Liang
mvif 46 program
11211
Reposted by @hcastelan.bsky.social
Michelle Wille @duckswabber.bsky.social · 23/01/2026
B3.13 viruses have high pathogenicity in mammals but low transmissibility: bovine and human derived viruses killed mice in 3-4 days, infected mice and hamsters. rMichigan/90 had slight slower replication. Bovine TX2/24 has broader tissue tropism 👉 www.biorxiv.org/content/10.6...
053
hcastelan.bsky.social @hcastelan.bsky.social · 23/01/2026
New paper out! Gut microbiota in Mexican adolescents is shaped by BMI, diet, and socioeconomic status. Obesity was linked to lower microbial diversity and higher Bacteroidetes and sugar-rich diets, and lower SES were associated with potential pathogens. onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
Gut Microbiota Composition in Adolescents From Mexico City, Associations With Nutritional and Socioeconomic Factors: Results From a Pilot Study
This study analyzed the gut microbiota composition of 95 adolescents and its relationship with body mass index, dietary habits, and socioeconomic status using 16S rRNA sequencing (V3-V4). The dominan...
031
Reposted by @hcastelan.bsky.social
Jeremy M. Brown @jembrown.bsky.social · 16/01/2026
Applications are now open for the 2026 Workshop on Molecular Evolution (MOLE)! www.mbl.edu/education/ad... Claudia Solis-Lemus and I will be holding an informational session on Zoom next Wed (1/21) from 10:30-11:30 AM Central for those interested: lsu.zoom.us/j/4968115684 Deadline to apply: 1/26
mbl.edu
Workshop on Molecular Evolution | Marine Biological Laboratory
The workshop serves graduate students, postdocs, and established faculty from around the world seeking to apply the principles of molecular evolution to questions of anthropology, conservation genetic...
02525
hcastelan.bsky.social @hcastelan.bsky.social · 26/12/2025
I’m happy to share a preprint I contributed to, analyzing the evolutionary “fingerprints” of protein-coding genes in RNA viruses. Surface-exposed proteins from enveloped viruses show patterns consistent with relaxed purifying selection rather than adaptive evolution.
032
Reposted by @hcastelan.bsky.social
EvolDir @evoldir.bsky.social · 26/12/2025
Join the University of Connecticut's RAD-seq virtual workshop (Jan. 13-16) for beginners. No prior bioinformatics experience needed. Learn data processing and variant calling. Register: bioinformatics.uconn.edu/cbc-worksh… #workshop
bioinformatics.uconn.edu
Training Workshops | Computational Biology Core
Training Workshops | Computational Biology Core
001
Reposted by @hcastelan.bsky.social
Sullivan Lab at OSU @sullivan-lab.bsky.social · 12/09/2025
🚨 New tool for viral genomics! Meet CLAE: a high-fidelity Nanopore sequencing strategy that pushes accuracy to Q30, boosts throughput >800 Mb/100 pores, and recovers full-length viral genomes from complex samples 🌊🦠 👉 [doi.org/10.1002/advs.202505978] #viromics #nanopore #genomics
1178
Reposted by @hcastelan.bsky.social
European Virus Bioinformatics Center @evbc.bsky.social · 29/09/2025
📢Join us for the next ECR #Viromics Webinar: "Characterising novel viral proteins using protein language models (PLMs)" ‍🎙️ Kieran Lamb (@kieranlamb.bsky.social) | University of Glasgow/UK 🗓️ 8 October 2025, 4 PM CEST 📍 Online | Zoom (register for login details) 👉 coms.osu.edu/webinars/ecr...
083
Reposted by @hcastelan.bsky.social
Ann Gregory, PhD @gregoryannc.bsky.social · 17/09/2025
🚨 We’re hiring! 🚨 The Integrative Viromics Lab @UCalgary 🇨🇦 is looking for a Lab Technician! 🔬 Phage isolation & culture 🧫 Anaerobic chamber work 📦 Lab management & student mentoring Apply now & help us explore the virosphere! You must have work authorization to work in Canada already.
136
Reposted by @hcastelan.bsky.social
Helen Branswell 🇨🇦 @helenbranswell.bsky.social · 07/02/2025
#USDA posted an analysis of the D1.1 #H5N1 #birdflu viruses that infected Nevada cows — the new spillover event. They spotted a mutation in the PB2 gene that is associated with mammalian adaptation. What's this mean? Dunno. But 2 spillovers means more could come. www.aphis.usda.gov/sites/defaul...
218081
Reposted by @hcastelan.bsky.social
Payal JS, PhD @payaljs.bsky.social · 24/01/2025
More than 40 percent of #postdocs leave academia. Those who landed a coveted faculty position were more likely to have had a highly cited paper, changed their research topic between their PhD and postdoc, or moved abroad after receiving their doctorate. #ChemSky www.pnas.org/doi/10.1073/...
pnas.org
Postdoc publications and citations link to academic retention and faculty success | PNAS
Postdoctoral training is a career stage often described as a demanding and anxiety-laden time when many promising PhDs see their academic dreams sl...
162
Reposted by @hcastelan.bsky.social
Max-Planck-Gesellschaft @maxplanck.de · 23/01/2025
More than 40 percent of #postdocs leave academia. Those who landed a coveted faculty position were more likely to have had a highly cited paper, changed their research topic between their #PhD and postdoc, or moved abroad after receiving their doctorate. www.pnas.org/doi/10.1073/... @pnas.org
nature.com
More than 40% of postdocs leave academia, study reveals
Publishing highly cited papers helps postdoctoral researchers to land a faculty job.
66827
Reposted by @hcastelan.bsky.social
Andrew Rambaut (🐏🎀) @arambaut.bsky.social · 03/02/2025
First genome sequence from the Ugandan Ebolavirus outbreak with analysis: virological.org/t/990 and first filovirus genome submitted to Pathoplexus database: pathoplexus.org/seq/PP_0011C.... Great (and rapid) work from the National Health Laboratory, UVRI and partners.
virological.org
Near Real-Time Genomic Characterization of the 2025 Sudan Ebolavirus Outbreak in Uganda’s Index Case: Insights into Evolutionary Origins
Introduction Case History: On January 30, 2025, the Ministry of Health declared an outbreak of Sudan Ebola Virus (SUDV) Disease in Kampala, Uganda, following the death of a healthcare worker at Mula...
310165
Reposted by @hcastelan.bsky.social
Guillaume Méric @gmeric.bsky.social · 15/01/2025
What are the genotypes promoting human colonization in S. aureus? Authors pooled >~7k genomes from >1500 ppl & looked at genomic variation to infer adaptation. Hits in metabolic genes (esp. nitrogen), QS, and antibiotic targets (incl. new resistance mutations). Cool! www.nature.com/articles/s41...
nature.com
The mutational landscape of Staphylococcus aureus during colonisation - Nature Communications
The authors applied a genomic and evolutionary approach to study Staphylococcus aureus in host adaptation during colonisation revealing signals of adaption in metabolic genes, in regulators of quorum-...
0174
Reposted by @hcastelan.bsky.social
Karthik Anantharaman @karthik-a.bsky.social · 08/01/2025
News and Views by @naturemicrobiol.bsky.social on our recent papers describing the 20-year study of ecology and evolution of viruses and bacteria in freshwater systems. @archaeal.bsky.social @quendi.bsky.social @uwmadison.bsky.social www.nature.com/articles/s41...
nature.com
Crucial stepping stones in freshwater microbiology - Nature Microbiology
Three different studies in this issue use metagenomics to study the bacterial and viral dynamics of freshwater microbiomes, highlighting the ecological and environmental drivers of these ecosystems.
1248
Reposted by @hcastelan.bsky.social
European Virus Bioinformatics Center @evbc.bsky.social · 03/12/2024
🚨 Save the Date! 🚨 We're excited to announce #ViBioM2025, the International Virus Bioinformatics Meeting, happening 13–15 May 2025 in Lisbon, Portugal! 🦠💻 Stay tuned for further details: evbc.uni-jena.de/vibiom2025/ #VirusBioinformatics
11913
Reposted by @hcastelan.bsky.social
Joanna Masel @joannamasel.bsky.social · 12/12/2024
We identified protein domains in LUCA (Last Universal Common Ancestor). Their distinctive amino acid usage reveals the order amino acids were added to the genetic code, based mostly on size. Older proteins hint at earlier alternative codes. 1/15 @seekingluca.bsky.social www.pnas.org/doi/10.1073/...
pnas.org
Order of amino acid recruitment into the genetic code resolved by last universal common ancestor’s protein domains | PNAS
The current “consensus” order in which amino acids were added to the genetic code is based on potentially biased criteria, such as the absence of s...
12262116
Reposted by @hcastelan.bsky.social
Stephen Turner @stephenturner.us · 09/12/2024
Spread-gl: visualising pathogen dispersal in a high-performance browser application academic.oup.com/bioinformatics/adv… 🧬🖥️🧪 github.com/GuyBaele/SpreadGL
094
Reposted by @hcastelan.bsky.social
Phage papers @phagepapers.bsky.social · 23/11/2024
MVP: a modular viromics pipeline to identify, filter, cluster, annotate, and bin viruses from metagenomes. DOI: 10.1128/msystems.00888-24 pubmed.ncbi.nlm.nih.gov/39352141
pubmed.ncbi.nlm.nih.gov
MVP: a modular viromics pipeline to identify, filter, cluster, annotate, and bin viruses from metagenomes - PubMed
While numerous computational frameworks and workflows are available for recovering prokaryote and eukaryote genomes from metagenome data, only a limited number of pipelines are designed specifically for viromics analysis. With many viromics tools developed in the last few years alone, it can be chal …
042
hcastelan.bsky.social @hcastelan.bsky.social · 09/12/2024
New paper out! www.mdpi.com/2072-6643/16.... In this study assessed how gut microbiota composition in 91 medical students varies based on fiber intake, ultra-processed food (UPF) consumption, sex, body mass index (BMI), and socioeconomic status.
mdpi.com
Gut Microbiota: Association with Fiber Intake, Ultra-Processed Food Consumption, Sex, Body Mass Index, and Socioeconomic Status in Medical Students
The gut microbiota plays a vital role in various physical and physiological processes, including immune system regulation, neurotransmitter production, inflammatory response modulation, and the inhibi...
142
Reposted by @hcastelan.bsky.social
Mike Barker @barkerms.bsky.social · 02/12/2024
🧪 Join us in Tucson! We will begin reviewing applications on December 9 for our tenure track faculty position on the genomics of resilience @uofa-eeb.bsky.social! Apply here: arizona.csod.com/ux/ats/caree...
A photo of a mountain road covered in snow with a rock wall on the right side and tall conifer trees on both side of the road. A bright orange sunset is in the background of the photo. Taken on Mt. Lemmon in the Santa Catalina Mountains above the city of Tucson, Arizona.
09457
Reposted by @hcastelan.bsky.social
European Virus Bioinformatics Center @evbc.bsky.social · 01/03/2024
As #ViBioM2024 approaches, we are excited to provide you with the final list of keynote speakers! Register now: evbc.uni-jena.de/events/vibio...
021
Reposted by @hcastelan.bsky.social
Simon Roux @simrouxvirus.bsky.social · 25/11/2024
Working on phages and considering maybe attending ASM Microbe 2025 in Los Angeles ? Then you should 100% join us and submit your abstract to the "Phage Ecology: From Prophage Decision Making to Ecosystem Modulation", led by @phagebeelicious.bsky.social and @cathyhernandez.bsky.social ! \o/
02210
Reposted by @hcastelan.bsky.social
Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 23/11/2024
Our Big Fantastic Virus Database (BFVD) is now published NAR! It contains protein structure predictions of major viral clades, enhanced by petabase-scale homology search and it's explorable on the web. 🌐 bfvd.foldseek.com 💾 bfvd.steineggerlab.workers.dev 📄 academic.oup.com/nar/advance-...
6339126