iiinova — where your digital self keeps evolving

Harry Orrin

@harryorrin.bsky.social

Postdoctoral researcher in Tom Deegan's group at Institute of Cancer and Genetics, Edinburgh, UK. Former PhD student in Joe Yeeles' group at MRC-LMB, Cambridge, UK.

Posts Replies Media

Harry Orrin @harryorrin.bsky.social · 27/08/2026

Very happy to share my PhD work showing how replisomes tolerate chemotherapeutic nucleoside analogues. A big thank you to @yeeles-lab.bsky.social, @mrclmb.ac.uk, @crukcamcentre.bsky.social, the editors at @embojournal.org, and the reviewers for their helpful comments and feedback on our study.

070

Reposted by Harry Orrin

Morgan Jones @04mjone.bsky.social · 14/10/2025

I’m really excited to share that I’ve been awarded a Wellcome Trust Career Development Award to start my own research group at Oxford University Biochemistry Department @BiochemOxford 🧬🎉

7525

Reposted by Harry Orrin

Deegan Lab @deeganlab.bsky.social · 15/04/2025

3rd edition of the fantastic UK DNA replication meeting is happening next September in Edinburgh. Don't miss out 🧬🏴󠁧󠁢󠁳󠁣󠁴󠁿 www.biochemistry.org/events-and-t...

biochemistry.org

UK DNA Replication Meeting 2026

Research in the DNA replication field is progressing at a remarkable rate. Technological innovations in biochemical reconstitution, structural biology, proteomics and DNA sequencing are helping to rap...

02216

Reposted by Harry Orrin

Morgan Jones @04mjone.bsky.social · 19/03/2025

Great new work from the very talented Emma Fletcher (@Yeeles_Lab). Biochemistry, and a touch of cryoEM, reveal why the DNA replication machinery needs a dedicated leading strand PCNA clamp loader. 🧬🧪🥼🔬🧑‍🔬 www.embopress.org/doi/full/10....

embopress.org

Competition for the nascent leading strand shapes the requirements for PCNA loading in the replisome | The EMBO Journal

imageimageCtf18-RFC is a dedicated leading-strand replication clamp loader, with RFC unable to fulfil this role. This study provides a mechanistic basis as to why this is the case and reveals unique f...

061