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Akash Gupta

@guptaakash.bsky.social

Research Scientist @ MIT

Akash Gupta @guptaakash.bsky.social · 14/05/2026

Thrilled to share our @NatureBiotech paper using mRNAs that generate stronger and durable T cell responses by driving DC maturation and activation. This work highlights how defined immune-signaling pathways, paired with controlled delivery, can shape potent therapeutic immunity

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Reposted by Akash Gupta

Yizhou Dong lab @yizhoudonglab.bsky.social · 26/11/2025

Congratulations to Yonger Xue & Xucheng Hou for leading the wonderful work on peptibody mRNA! Thanks @miriammerad.bsky.social for the huge support! Thanks Rong Li @natbiotech.nature.com and reviewers for the amazing review process! Thanks @NIH @IcahnMountSinai!

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Akash Gupta @guptaakash.bsky.social · 08/11/2025

Our latest work @mitkochinstitute.bsky.social is now published in @natnano.nature.com ! By optimizing lipid nanoparticle design, we significantly improved #mRNA expression and immune responses — paving the way for a new class of delivery systems for #vaccine. Free access - rdcu.be/eOLjb #biotech

rdcu.be

Degradable cyclic amino alcohol ionizable lipids as vectors for potent influenza mRNA vaccines

Nature Nanotechnology - This work presents a degradable ionizable lipid, AMG1541, for mRNA vaccines that significantly enhances potency and enables similar protective immunity at doses 100-fold...

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