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George Hall @gthall.bsky.social · 24/04/2026

[2] "Functional integration of an autologous engineered esophagus in a large-animal model", Nature Biotechnology (2026), with Natalie Durkin, @marcopll.bsky.social, @paolodecoppi.bsky.social. [3] Manuscript under preparation - watch this space, with Leilani Hoffmann and Sergi Castellano. (9/9)

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George Hall @gthall.bsky.social · 24/04/2026

[1] "An in vivo and in vitro spatiotemporal profile of human midbrain development", Nature Communications (2026), with Dimitri Budinger, @paupuigdevall.bsky.social, Manju Kurian, Serena Barral. (8/9)

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George Hall @gthall.bsky.social · 24/04/2026

It's always vital to keep this end goal in mind as we work in the sometimes more abstract world of method development. Thanks again all - see you next year! #UCL2026AdvTx #CellTherapy #GeneTherapy #TranslationalResearch #AdvancedTherapies #Biotech #AI #AIforBiology (7/9)

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George Hall @gthall.bsky.social · 24/04/2026

Finally, it's always a pleasure to hear from colleagues at @uclchildhealth.bsky.social and @greatormondst.bsky.social about the fantastic work they are doing to develop innovative treatments for some of the rarest yet most severe diseases in the world. (5/9)

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George Hall @gthall.bsky.social · 24/04/2026

Lots of insightful discussions with people from industry working across drug discovery, development, regulation, and funding - very pleased to see interest in this approach from all areas! (4/9)

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George Hall @gthall.bsky.social · 24/04/2026

Also showed how we can use artificial intelligence to automate and improve our bioengineering processes [3]. (3/9)

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George Hall @gthall.bsky.social · 24/04/2026

It was a nice opportunity to present our work on how we can use spatial transcriptomics to assess the quality of lab-grown tissues, whether they be organoid models of disease [1] or manufactured organs themselves [2]. (2/9)

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George Hall @gthall.bsky.social · 24/04/2026

Many thanks to the UCL Translational Research Office @ucltro.bsky.social for inviting me to give a talk "High-resolution quality control in new cells and tissues using single-cell and spatial transcriptomics" at their Advanced Therapies Symposium 2026. (1/9)

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George Hall @gthall.bsky.social · 23/03/2026

Key challenge is estimating future changes of complex spatial features from data with very few, very high dimensional training instances. I believe such methods have potential to help many people - please get in touch with me if this sounds like something that interests you!

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George Hall @gthall.bsky.social · 23/03/2026

Related to this work but on the computational side of things, Sergi Castellano and I are working towards developing a general ML framework for the automated quality control of bioengineered tissues and organs by predicting their development following transplantation.

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George Hall @gthall.bsky.social · 23/03/2026

Very proud also to see this work receiving coverage in the media (BBC News: www.bbc.co.uk/news/article..., Sky News: news.sky.com/story/first-...).

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George Hall @gthall.bsky.social · 23/03/2026

I analysed developing structure of the organs with spatial transcriptomics, showing they become increasingly similar to biological oesophagi after transplant. This was the first time that lab-grown organs have been profiled using spatial transcriptomics.

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George Hall @gthall.bsky.social · 23/03/2026

Proud to be second author on "Functional integration of an autologous engineered esophagus in a large-animal model", out now in Nature Biotechnology (www.nature.com/articles/s41...). In it, Paolo De Coppi and team created lab-grown oesophagi that integrated and grew inside pigs.

nature.com

Functional integration of an autologous engineered esophagus in a large-animal model - Nature Biotechnology

A tissue-engineered esophageal segment is functional in minipigs.

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George Hall @gthall.bsky.social · 18/03/2026

A nice write-up of a paper where I am co-first author (published in Nature Communications last month - www.nature.com/articles/s41...)

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George Hall @gthall.bsky.social · 04/02/2026

New blog post! A basic introduction to git for those that have never used it before: ghall.co.uk/blog/2026/in.... Focuses on getting started with version control and worrying about best practices later. Perfect is the enemy of good!

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George Hall @gthall.bsky.social · 16/01/2026

Blog post #3: This one is a little more niche - how to allow the Ray Tune hyperparameter optimization framework to interface with the Sun Grid Engine (SGE) job scheduler: ghall.co.uk/blog/2026/ra...

ghall.co.uk

Running Ray Tune on Sun Grid Engine | George Hall

My personal site!

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George Hall @gthall.bsky.social · 16/01/2026

Blog post #2: How to verify that two directories are identical using checksums. Essential if copying large, expensive datasets, for example: ghall.co.uk/blog/2025/ve...

ghall.co.uk

How to check whether two directories are identical | George Hall

My personal site!

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George Hall @gthall.bsky.social · 16/01/2026

I've started a blog! First few posts are things where I often share with colleagues my approaches - sharing online in the hope they are useful to others! Post #1: My .bashrc, .inputrc and .vimrc configuration files: ghall.co.uk/blog/2025/co...

ghall.co.uk

My configuration files | George Hall

My personal site!

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