Alport syndrome (AS) is the most common inherited glomerular disease,1 caused by pathogenic (P) or likely pathogenic (LP) variants in three collagen IV genes: COL4A5, which leads to X-linked AS (XLAS)...

Neural epidermal growth factor-like 1 (NELL1) is a novel antigen in membranous nephropathy (MN). Our observations indicate that a subset of patients with NELL1-associated MN demonstrate focal positive...

Collapsing glomerulopathy (CG) in the native kidney is typically associated with heavy proteinuria, rapid progression to kidney failure, and frequent presence of APOL1 kidney risk variants (KRVs).1 In...

Membranous nephropathy (MN) is a rare autoimmune kidney disease mediated by autoantibodies directed against podocyte antigens, such as phospholipase A2 receptor type 1 (PLA2R1). MN exhibits marked cli...

In 2025, the World Health Organization specifically called for action to address the epidemics of chronic kidney disease of undetermined etiology (CKDu) occurring in low-income agricultural settings a...

Delayed graft function after kidney transplant is associated with increased acute rejection rates and poorer long-term outcomes. It is significantly more prevalent in recipients of deceased than livin...

The thick ascending limb (TAL) of Henle’s loop has long fascinated scientists and clinicians and interest has increased recently because genes expressed there are useful biomarkers for kidney injury. ...

Congenital anomalies of the kidney and urinary tract (CAKUT) are a heterogeneous group of structural defects that arise from disordered nephrogenesis. CAKUT accounts for 20%–30% of all prenatal anomal...

Nephrectomy results in abrupt nephron loss and variability in postoperative estimated glomerular filtration rate (eGFR) trajectories that is incompletely explained by baseline clinical factors. Adapti...

Introduction: in kidney transplantation, the donor kidney should provide sufficient nephron mass to meet recipient demands. Whilst nephron mass cannot be easily measured, size-mismatch metrics could b...

Diabetic kidney disease (DKD) remains the leading global cause of end-stage kidney failure. Sodium-glucose cotransporter 2 inhibitors, mineralocorticoid receptor antagonists, and other kidney-protecti...

Congenital anomalies of the kidneys and urinary tract (CAKUT) are the commonest cause of kidney failure in children and young adults. Over 50 monogenic causes have been identified. However, fewer than...

The prognostic value of achieving the European League Against Rheumatism (EULAR) 3- and 6-month treatment targets in lupus nephritis (LN) remains uncertain.

Renal tubular casts are cylindrical structures formed primarily in the distal convoluted tubule or collecting tubule. They are composed of materials filling the tubular lumen and molding along its ...

Given the challenges in diagnosing transplant thrombotic microangiopathy (Tx-TMA) highlighted in previous publications, the objectives were to: 1- summarize new diagnostic challenges of Tx-TMA; 2- exp...

The complement cascade is part of the innate immune system, and it provides an important line of defense against infections. Inappropriate or excessive activation of this system, however, is also a dr...

Hereditary fibrinogen A alpha-chain (AFib) amyloidosis is characterised by progressive proteinuric chronic kidney disease (CKD) and early progression to end-stage renal disease (ESRD). A large series ...

Diabetic nephropathy (DN) remains the leading cause of kidney failure worldwide. Histopathologic assessment is the diagnostic standard, and the Renal Pathology Society (RPS) classification system is w...

Renal infarction is rare with only retrospective cohort studies published. To better understand renal infarction, we conducted a systematic review and meta-analysis of proportions for 1) incidence and...

Kikuchi-Fujimoto Disease (KFD) is a rare, self-limiting disorder primarily involving lymph nodes and characterized by necrotizing lymphohistiocytic inflammation with prominent apoptotic debris. Extra-...

Abstract. CFTR modulators have been revolutionary for cystic fibrosis patients but their potential influence on AA amyloidosis has not been investigated. T

Global Partner Travel Award APPLICATIONS NOW OPEN Deadline: Tuesday, August 27, 2026 APPLY NOW Applications are now open for the Global Partner Travel Award for our 2027 Annual Meeting in Vancouver, B...

Immunoglobulin A nephropathy (IgAN) is an immune-mediated glomerular disease driven by dysregulated mucosal B-cell immunity, leading to the overproduction of galactose-deficient IgA1 (Gd-IgA1) and the...

VEGF-axis inhibitors, including VEGF ligand-directed agents such as bevacizumab and VEGF receptor-targeted tyrosine kinase inhibitors (TKIs), are integral to the treatment of advanced solid tumors. Th...

Non-GFR determinants of filtration markers reduce the accuracy of estimated GFR (eGFR) and genetic factors may explain part of this reduced performance. Here, we identify genetic variants associated w...

Mitochondrial alterations are increasingly recognized as central to the pathogenesis of chronic kidney disease (CKD), contributing to impaired energy metabolism, oxidative stress, and maladaptive cell...

While a few studies have investigated renal manifestations associated with mitochondrial DNA (mtDNA) mutations, detailed renal histopathological changes and long-term outcomes remain poorly characteri...

Loin pain hematuria syndrome (LPHS) is characterized by chronic loin pain and hematuria without a urological cause. We hypothesized that rare genetic variants in genes impacting the glomerular filtrat...

Autoantibodies targeting complement factor B (anti-FB) are among the most recently described alternative pathway anomalies. Although they have been strongly associated with post-infectious glomerulone...

The podocyte slit diaphragm (SD) is a specialized intercellular junction connecting adjacent podocytes that mediates size-selective passage of primary filtrate into Bowman's space. The SD’s principal ...