iiinova — where your digital self keeps evolving

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 4h

Global Incidence of All-Cause Dementia: A Meta-Analysis ➡️ Results showed that #Dementia cases will likely more than double, as global population ages; 24.7 million new cases of dementia by 2050, up from 11.4 million in 2023." Full Study @jamaneurology.com 👉 jamanetwork.com/journals/jam...

000

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 06/10/2026

My deepest thanks and congratulations to Dr. Greta Strong for her exceptional leadership in organizing the MIPO ’s 15th Power of Partnerships, Scholarships and Hall of Fame Gala. This milestone event celebrated 15 years of community impact. Again, congratulations, Dr. Strong.

000

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 02/10/2026

Yesterday, I had a fantastic time presenting a keynote at The 14th #Microbiome & #Probiotics R&D and Business Collaboration Forum. The Forum highlights how #Genomics, #SyntheticBiology, and advanced #Bioengineering are rapidly transforming microbiology. A Huge Thank You to the organizers!

110

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 30/09/2026

Excited about attending the Microbiome & Probiotics R&D & Business Collaboration Forum. Tomorrow, Oct. 1, 9am (PT), I will present the keynote “Role of the Immune T Regulatory Cells in Mood Disorders and #AlzheimersDisease Phenotype as a therapeutic target in Altered #GutBrain Axis cross-talking”.

110

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 28/09/2026

Researchers Suborno Jati, Xu Chen, Sushil Mahata, et al. @ucsdmedschool.bsky.social ID'd a naturally occurring peptide, a small protein fragment called catestatin, that may help counter several key processes driving #Neurodegeneration. @moltherapy.bsky.social 👉 www.sciencedirect.com/science/arti...

011

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 26/09/2026

Check Out: "Cholesterol dysregulation in APOE4 astrocytes promotes α-synuclein pathology in miBrains" - Louise A. Mesentier-Louro, Camille Goldman, Sebastian Gaese, Panos Roussos, Vikram Khurana, @joelwblanchard.bsky.social, et al. @cp-cellstemcell.bsky.social 👉 www.cell.com/cell-stem-ce...

001

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 26/09/2026

Check Out: "A pericyte-to-myofibroblast transition links APOE4 to cerebrovascular degeneration" - Braxton Schuldt, Dominic Haworth-Staines, Alison Goate, Towfique Raj, Ana C. Pereira, @joelwblanchard.bsky.social, et al. @cellcellpress.bsky.social 👉 www.cell.com/cell/fulltex...

100

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 26/09/2026

Exciting Research! Researchers @joelwblanchard.bsky.social, et al have ID'd how APOE4 damages brain’s blood vessels and promotes the buildup of abnormal proteins linked to #NeurodegenerativeDisease. Overview from @mountsinainyc.bsky.social Newsroom www.mountsinai.org/about/newsro...

100

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 23/09/2026

I am deeply honored to have received an EPN NYFW Icons and Excellence Award. My sincere gratitude to the EPN organization, Hubert Delany (CEO & Co-Founder) and Magdaline Delany (President & Co-Founder) for this wonderful honor. Congratulations to all of my fellow honorees!

001

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 23/09/2026

In this study, Giuseppe Lanza, Filippo Caraci, et al. investigated the association between habitual dietary (poly)phenol intake, cognitive status, and circulating inflammatory biomarkers in older adults. Learn More in @mdpiopenaccess.bsky.social | Antioxidants 👉 www.mdpi.com/2076-3921/15...

000

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 22/09/2026

In this new paper, the #PasinettiLab sheds light on physiological connections between digestive and genitourinary systems, explore how endocrine and immune networks exert dual control across compartments, and analyze correlations between dysbiosis and disease states. 👉 doi.org/10.1080/1949...

000

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 21/09/2026

Mark Your Calendars 🗓 10 Days Away! On Oct. 1-2, join industry leaders, researchers, and innovators to facilitate collaboration in the rapidly evolving field of #Microbiome research and #Probiotic development. Learn More | Register Here 👉 global-engage.com/conferences/...

111

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 15/09/2026

Researchers Leon Aksman, et al. have uncovered evidence that two neighboring types of brain tissue, superficial white matter and gray matter, may work together to support thinking abilities later in life. Learn More @alzdemjournals.bsky.social 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

010

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 14/09/2026

Researchers @cakizil.bsky.social, et al. @columbiamed.bsky.social ID astrocyte-derived fibronectin as a primary driver of #BloodBrainBarrier breakdown in carriers of the APOE ε4 allele - offer a potential non-amyloid therapeutic target for #Alzheimers. Nature Aging 👉 www.nature.com/articles/s43...

021

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 12/09/2026

I am deeply honored to have been recognized at the 2026 EPN Magazine Icons and Excellence Gala. It was an unforgettable evening. Thank you to EPN Magazine for this incredible honor, and congratulations to my fellow honorees.

000

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 10/09/2026

See the FULL STUDY in the Journal of Alzheimer’s Disease, "Exposure to #WorldTradeCenter Dust Exacerbates Cognitive Impairment and Evokes a Central and Peripheral Pro-Inflammatory Transcriptional Profile in an Animal Model of Alzheimer's" 👉 doi.org/10.3233/JAD-...

000

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 10/09/2026

As we honor those who made the ultimate sacrifice on September 11th, the #PasinettiLab remains committed to studying the effects of exposure to the Ground Zero debris on the first responders and survivors. PRESS RELEASE 👉 www.mountsinai.org/about/newsro...

100

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 10/09/2026

This week marks the 25th anniversary of the September 11th, 2001 terrorist attacks on the #WorldTradeCenter. While that day is seared into our memories; for thousands of first responders and survivors, its physical toll and health consequences are still being felt today.

100

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 10/09/2026

I am incredibly proud to share that I have been chosen to receive an EPN NYFW Icons and Excellence Award this coming Friday night. To be acknowledged alongside such a distinguished group of leaders is truly an honor. Learn More 👉 epnofny.com/epnmag/blog/...

000

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 09/09/2026

Caitlin Finney, et al. demo APOE ε4 acts as systemic immune modulator that creates early vulnerability to #Neurodegeneration & shifts focus toward targeted, early preventative interventions before #CognitiveDecline. @alzdemjournals.bsky.social 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

010

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 03/09/2026

In a new study, researchers Nicola Johnstone & Kathrin Cohen Kadosh provide new insight into the #Gut #Brain axis offering some of the strongest evidence yet that the #Microbiome may play a role in shaping human neurochemistry. Learn More in Molecular Psychiatry 👉 www.nature.com/articles/s41...

131

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 02/09/2026

Researchers Carlos Diaz-Salazar, Franck Polleux, et al. have found, for first time, that human #Microglia, much like human neurons, mature far more slowly than comparable cells in other animals. @zuckermanbrain.bsky.social Learn More in Neuron | @cellpress.bsky.social 👉 www.cell.com/neuron/fullt...

010

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 01/09/2026

Mark Your Calendars 🗓 One Month Away! On October 1-2, join industry leaders, researchers, and innovators to facilitate collaboration in the rapidly evolving field of #Microbiome research and #Probiotic development. Learn More | Register Here 👉 global-engage.com/product/micr...

120

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 31/08/2026

Here, Arsenio Paez, et al. investigated if nonrapid eye movement SP-SO activity is assoc w/ CSF orexin & whether these oscillatory features moderate assoc btwn #Orexin, #Cognition, #NeuropsychiatricSymptom severity & #Alzheimers biomarkers. @greenjournal.bsky.social www.neurology.org/doi/10.1212/...

000

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 27/08/2026

In this study, Brad Dickerson, Mark Eldaief, Alexandra Touroutoglou, et al. examined whether baseline cortical atrophy predicts progression to #Dementia in patients w/ #MildCognitiveImpairment because of #EarlyOnsetAlzheimersDisease. @greenjournal.bsky.social 👉 www.neurology.org/doi/10.1212/...

011

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 26/08/2026

I am thrilled to announce that the #PasinettiLab 's latest paper, "The cervicovaginal #Gut #Microbiota axis as a key determinant of systemic physiology", has been officially accepted for publication in Gut Microbes. MORE TO COME!

120

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 21/08/2026

Researchers YingxuLiu, Leon Aksman, et al. have uncovered evidence that cognition in older adults may depend on more than the preservation of gray matter alone. Learn More in #Alzheimers & #Dementia | The Journal of @alzassociation.bsky.social 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

000

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 20/08/2026

EXCITING! Here, @irenefaravelli.bsky.social @bolanosanton.bsky.social, Paola Arlotta, et al. @harvard.edu have dvlpd human brain organoids for 5 years in culture, optimizing growth conditions to extend excitatory neuron viability beyond previous limits. @nature.com 👉 www.nature.com/articles/s41...

000

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 17/08/2026

Ahead of 14th Microbiome R&D & Business Collaboration Forum, Dr. Pasinetti shares why he believes the field should shift its focus towards peripheral adaptive immune system & role of regulatory T cells in linking the #Gut #Microbiome with #BrainHealth. Learn More 👉 global-engage.com/resource-cen...

000

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 12/08/2026

The brain's immune cells are increasingly recognized as key players in #Alzheimers, but exactly how they change as the disease develops has remained unclear. A NEW STUDY by Donghoon Lee, Panos Roussos, et al. provides the most comprehensive map to date of these cells.👉 www.nature.com/articles/s41...

000

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 04/08/2026

Our new review article examines the structural variety, distribution, and physicochemical properties of #ChlorogenicAcids (CGAs), identifying coffee and green coffee as the leading dietary sources of these compounds. Full Text @mdpiopenaccess.bsky.social | Nutrients 👉 www.mdpi.com/2072-6643/18...

011

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 04/08/2026

Researchers Andrei Irimia, et al. at the University of Southern California have developed an imaging-derived technique that uses #ArtificialIntelligence to generate detailed maps that highlight differences in how distinct parts of the brain age. Learn More @pnas.org 👉 www.pnas.org/doi/10.1073/...

011

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 31/07/2026

COMING UP! The Microbiome & Probiotics R&D & Business Collaboration Forum brings together industry leaders, researchers, & innovators to facilitate collaboration & knowledge exchange in the field of #Microbiome research & #Probiotic development. Learn More 👉 global-engage.com/wp-content/u...

111

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 31/07/2026

NEW STUDY | OUT NOW! Here, Dr. Carlos Toro & I use machine-learning models on NHANES data to demonstrate that combining demographic profiles w/ exposomic biomarkers is powerful strategy for predicting cognitive performance. @mdpiopenaccess.bsky.social | Brain Sciences 👉 www.mdpi.com/2076-3425/16...

010

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 30/07/2026

Between the healthy version & the large plaques it forms in #Alzheimers, there is an intermediate state of #Amyloid beta. Researchers @yalemedicine.bsky.social have now ID'd this structure, which could open new, more effective treatment options. Nature Communications 👉 www.nature.com/articles/s41...

042

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 23/07/2026

The brain continuously produces metabolic waste that must be removed. Yet one question has remained: How does #CerebrospinalFluid cross the arachnoid membrane? A team, led by Gou Young Koh at IBS, has identified the missing anatomical gateway. @cellpress.bsky.social 👉 www.cell.com/cell/fulltex...

021

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 21/07/2026

New reseach by Roberto Vicinanza, Pasquale Pignatelli, Pinchas Cohen, et al. has found that the #MediterraneanDiet may influence aging through tiny proteins produced inside the cell’s #Mitochondria. Full Study in Frontiers in Nutrition www.frontiersin.org/journals/nut... @uscedu.bsky.social

122

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 20/07/2026

Researchers Nicholas Constantino, Shannon Macauley et al. at University of Kentucky found that #Microglia are the main drivers of sleep loss in an animal model of Alzheimer's. Learn More in #Alzheimers & #Dementia | @alzassociation.bsky.social 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

020

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 17/07/2026

Study from Vanessa Young, et al. @uthealthsa.bsky.social suggests regularly sleeping long hours each night assoc w/ higher levels of an #Alzheimers -related protein in blood, even accounting for other health factors. @alzdemjournals.bsky.social 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

010

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 13/07/2026

New Study by Renée Kosonen, Kristie Stefanoska, Yijun Lin, et al. has revealed that tau, best known for its connection to #Alzheimers, is also essential for creating long lasting memories. At Nature Communications 👉 www.nature.com/articles/s41... Science Daily 👉 www.sciencedaily.com/releases/202...

000

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 09/07/2026

Excited to share this new protocol paper! As #Botanicals & nutritional supplements gain popularity for physical & #MentalHealth, rigorous human studies to validate absorption, #Bioavailability, & physiological effects are more important than ever. At Elsevier 🌿 www.sciencedirect.com/science/arti...

111

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 08/07/2026

Here, Xia Zhang, et al. establish a specific link between cardiac dysfunction & cognitive decline based on microstructural brain alterations & ID a 'heart-brain continuum' where routine cardiac biomarkers predict future brain microstructural damage. @sfnjournals.bsky.social 👉 doi.org/10.1523/JNEU...

010

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 07/07/2026

It was so exciting to chair the roundtable “Bridging Multimodal Biomedical Data for Neuro-Clinical Translation | Multimodal Data Fusion for Early Interception of #AlzheimersDisease” at the 11th Neurological Disorders Summit! Thank you to my colleagues for joining me for this fantastic discussion.

000

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 06/07/2026

It was a fantastic morning at the 11th Neurological Disorders Summit 2026 where I gave a Plenary presentation: “Role of the Immune T Regulatory Cells in Mood Disorders and Alzheimer's Disease Phenotype as a therapeutic target in Altered Gut-brain Axis cross-talking”.

001

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 05/07/2026

TOMORROW! I am looking forward to the 11th Neurological Disorders Summit 2026 in Boston, July 6th - 8th. On July 6th, 8:55am, I will give a Plenary presentation and, at 5:50pm, I will chair and moderate a panel discussion. It will be very exciting! Learn More 👉 nds.unitedscientificgroup.org

000

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 03/07/2026

This July 4th, we celebrate America's 250th birthday and the anniversary of the Declaration of Independence! From all of us at the #PasinettiLab to all of our friends & colleagues, please have an incredible, happy, fun & safe #FourthofJulyWeekend! #IndependenceDay2026 #FourthOfJuly #America250

000

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 30/06/2026

Furthermore, I was thrilled that my friend, and an inspiration, Nobel laureate Prof Thomas C. Südhof was the recipient of the 2026 Pioneer in Medicine Award from the World Brain Mapping Foundation. It was a wonderful celebration of innovation in neuroscience, technology, and health policy.

000

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 30/06/2026

On April 17, the World Brain Mapping Foundation held its 23rd Annual Gathering for Cure Awards Gala at The Biltmore LA. I was incredibly honored to have been selected to receive the SBMT 2026 Golden Axon Leadership Award. What a fantastic event & beautiful evening! Again, Thank You Dr. Babak Kateb.

121

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 30/06/2026

COMING UP FAST 🚀 I am looking forward to the 11th Neurological Disorders Summit 2026 in Boston. On July 6th, 8:55am, I will give a Plenary presentation and, at 5:50pm, I will chair and moderate a great panel discussion. VERY EXCITING! Learn More 👉 nds.unitedscientificgroup.org

000

Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 27/06/2026

VERY EXCITED! I am looking forward to the 11th Neurological Disorders Summit 2026 in Boston, July 6th - 8th. On July 6th, 8:55am, I will give a Plenary presentation and, at 5:50pm, I will chair and moderate a panel discussion. It will be very exciting! Learn More 👉 nds.unitedscientificgroup.org

000