Giorgia Guglielmi describes how optogenetics helped illuminate the path tissues follow to get in shape for her PhD project

Small deletions in an X-linked RNA alter social and repetitive behaviors in male mice without broadly affecting learning or memory.

Deleting a small region of the MECP2 gene partially restored function in neurons derived from people with Rett-associated variants.

Nature highlights developments in women’s health research and career guidance for women in science.

Drug trials have typically excluded pregnant people for safety reasons. But that’s now starting to change.

Immense progress in gene editing, drug discovery and conservation are just some of the reasons to be cheerful about 2025.

Drug companies are trialling a host of medications that they hope will offer benefits beyond weight loss.

The rapid eye movement (REM) phase preserves newly acquired memories, but deeper non-REM sleep helps to adapt and update them, according to “heroic” day-long electrode recordings in rats.

In response to US turmoil, premier establishments such as the European Research Council have sweetened incentives to attract talent.

Data reveal how this year’s back-to-back heatwaves are affecting populations and economies across Europe.

An analysis of autistic children and their siblings underscores the idea that autism can be viewed as multiple conditions with distinct trajectories.

Boys and girls may be vulnerable to different genetic changes, which could help explain why the condition is more common in boys despite linked variants appearing more often in girls.

President Trump’s budget office lays out guidelines for mass lay-offs across the federal government.

The annual awards are a celebration of weird but thought-provoking science.

Data reveal how this year’s back-to-back heatwaves are affecting populations and economies across Europe.

An analysis of autistic children and their siblings underscores the idea that autism can be viewed as multiple conditions with distinct trajectories.

In response to US turmoil, premier establishments such as the European Research Council have sweetened incentives to attract talent.

Five US-based researchers tell Nature why they are exploring career opportunities overseas.

Recognize early-career researchers who have made outstanding contributions to the field. Selected nominees will be featured on our website and in our annual book.

The statistical approach helps scientists better control for both measured and unmeasured confounders in gene-expression data.

Lack of screening and limited treatment options mean that low- and middle-income countries face higher death rates despite having fewer cases than wealthier nations.

The cells primarily rely on glucose—rather than lactate from astrocytes—to generate energy, according to recent findings in mice.

Drug companies are trialling a host of medications that they hope will offer benefits beyond weight loss.

The regulator, CPEB4, typically controls protein production for hundreds of autism-linked genes, but an alternative version of it found in autistic people forms irreversible clumps and malfunctions.

Weight-loss medicines such as Ozempic might raise a person’s likelihood of developing conditions including arthritis.

Fresh approach to diagnosing the condition looks at how excess body fat affects the body.

Understanding the interplay among rival signals, such as pain, thirst and fear, could provide insights into anxiety and other neuropsychiatric conditions.