iiinova — where your digital self keeps evolving

Gianluca Zambanini @gianlucazamba.bsky.social · 13/12/2025

Another impressive work out of the Cantù lab!!! Congratulations to @annanordin.bsky.social and @claudiocantu81.bsky.social for developing this great technology (Can’t wait to try it)

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Reposted by Gianluca Zambanini

Blanka Majchrzycka @blanka-majchrzycka.bsky.social · 17/10/2025

Out now! 🎉 Check the thread & preprint to see why we think E–P specificity is real in mammals — and, well, a few other interesting things popped up too 👀 Huge thanks to @danielibrahim.bsky.social, @arnaudkr.bsky.social & @stemundi.bsky.social and fantastic people in their labs — what a journey! 🧪🔬

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Gianluca Zambanini @gianlucazamba.bsky.social · 24/07/2025

Congrats to all for the great work! And congrats to @annanordin.bsky.social like always impeccable work! 🎉🎉🎉

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Reposted by Gianluca Zambanini

Juliane Glaser @julianeg.bsky.social · 09/07/2025

Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁 Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5

nature.com

Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes - Nature Genetics

Activation of an LTR retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles in the mouse developing limb, triggering apoptosis and causing limb malformation. This phenotype c...

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Reposted by Gianluca Zambanini

Claudio Cantù @claudiocantu81.bsky.social · 12/05/2025

We had previously shown that TBX3 and #WNT cooperate in limb #DevBio We now have a shocking finding, just published in @pnas.org TBX3 physically engages with β-catenin to drive metastasis genes in #ColorectalCancer (CRC) www.pnas.org/doi/epub/10....

pnas.org

The developmental factor TBX3 engages with the Wnt/β-catenin transcriptional complex in colorectal cancer to regulate metastasis genes

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Reposted by Gianluca Zambanini

Konrad Chudzik @konrad-chudzik.bsky.social · 08/05/2025

🚨 Preprint 🚨 Ever wondered how cells prepare their genomes to enable new cell-fates? In this team up with the Kind lab, we show that genes are repositioned in the nucleus to get ready for future activation and tissue formation. Read 🧵👇 to find out how and when this happens! doi.org/10.1101/2025...

biorxiv.org

Reconfiguration of genome-lamina interactions marks the commissioning of limb cell-fates

Diverse forms of heterochromatin block inappropriate transcription and safeguard differentiation and cell identity. Yet, how and when heterochromatin is reconfigured to facilitate changes in cell-fate...

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Gianluca Zambanini @gianlucazamba.bsky.social · 15/04/2025

A bit late on this but happy to share one of the last project I participated in the Cantù lab! Thanks to @annanordin.bsky.social, @claudiocantu81.bsky.social and all the other people without whom this project would have not been possible.

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Reposted by Gianluca Zambanini

Konrad Chudzik @konrad-chudzik.bsky.social · 14/04/2025

🚨 Preprint alert 🚨 Excited to share our work on "Ab-trapping," an antibody artifact causing misleading peripheral ("rim") staining in imaging & genomics (IF, CUT&Tag, CUT&RUN). Antibodies fail to penetrate structures, accumulating at the periphery. A 🧵👇 doi.org/10.1101/2025...

doi.org

Ab-trapping - a peripheral staining artifact in antibody-based microscopy and genomics

Antibodies (Ab) are essential for detecting specific epitopes in microscopy and genomics, but can produce artifacts leading to erroneous interpretations. Here, we characterize a novel artifact, Ab-tra...

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