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genomicspat.bsky.social

@genomicspat.bsky.social
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Carl Zimmer @carlzimmer.com · 21/11/2025
"At this time, I suggest the general public avoid the CDC website." --epidemiologist @kkjetelina.bsky.social open.substack.com/pub/yourloca...
open.substack.com
One of CDC’s final blows. And what it means for you.
Where to find trusted health information now?
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genomicspat.bsky.social @genomicspat.bsky.social · 30/10/2025
x.com/diagnostic_m...
x.com
Diagnostics MDPI on X: "🎊First article published in the Special Issue 'Point-of-Care Testing (#POCT) for Infectious Diseases' "An ERA-CRISPR/Cas12a Method for Highly Sensitive Detection of Human #Adenovirus Type 55" by Letian Zhang et al. 📖Check out the full publication at https://t.co/7BA6Ggc7SO https://t.co/LZvZ7DIAIB" / X
🎊First article published in the Special Issue 'Point-of-Care Testing (#POCT) for Infectious Diseases' "An ERA-CRISPR/Cas12a Method for Highly Sensitive Detection of Human #Adenovirus Type 55" by Letian Zhang et al. 📖Check out the full publication at https://t.co/7BA6Ggc7SO https://t.co/LZvZ7DIAIB
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genomicspat.bsky.social @genomicspat.bsky.social · 30/10/2025
www.sciencedirect.com/science/arti...
sciencedirect.com
Weakly supervised deep learning-based detection of serous tubal intraepithelial carcinoma in fallopian tubes
Serous tubal intraepithelial carcinoma (STIC) is an uncommon, non-invasive carcinoma that occurs more frequently in individuals with germline BRCA mut…
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genomicspat.bsky.social @genomicspat.bsky.social · 08/05/2025
Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control url:https://aacrjournals.org/cancerres/article/doi/10.1158/0008-5472.CAN-25-0351/762071/Adaptive-Therapy-Exploits-Fitness-Deficits-in
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genomicspat.bsky.social @genomicspat.bsky.social · 30/04/2025
bmccancer.biomedcentral.com
Correlation between EpCAM expression and cervical lymph node metastasis in papillary thyroid carcinoma: a study integrating ultrasonographic features - BMC Cancer
Objectives The epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein that is overexpressed in various epithelial tumors and has been associated with tumor aggressiveness and unfavo...
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genomicspat.bsky.social @genomicspat.bsky.social · 15/04/2025
cell.com
Recurrent breakpoints in the BRD4 locus reduce toxicity associated with gene amplification
Wala et al. identify recurrent focal BRD4 deletions in tumors harboring larger amplifications, suggesting that these deletions may serve to limit toxic BRD4 overexpression. A CRISPR-Cas9 cell line mod...
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genomicspat.bsky.social @genomicspat.bsky.social · 15/04/2025
ascopubs.org
Endocrine Therapy Omission in Estrogen Receptor–Low (1%-10%) Early-Stage Breast Cancer
PURPOSEAdjuvant endocrine therapy (ET) improves overall survival (OS) in estrogen receptor (ER)–positive early-stage breast cancer (BC). However, the benefit of ET for those with ER-low BC (ER 1%-10%)...
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genomicspat.bsky.social @genomicspat.bsky.social · 12/04/2025
www.kcl.ac.uk/news/study-s...
kcl.ac.uk
Study shows how new antibody therapy works against ovarian cancer
Research has shed light on how a new type of antibody treatment reactivates patients’ immune cells to fight ovarian cancer.
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genomicspat.bsky.social @genomicspat.bsky.social · 09/04/2025
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
Proposal for an optimised definition of adverse pathology (unfavourable histology) that predicts metastatic risk in prostatic adenocarcinoma independent of grade group and pathological stage
We show that specific histological patterns of prostatic adenocarcinoma are highly sensitive for predicting metastatic potential, independent of grade group and pathological staging. We propose a sim....
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genomicspat.bsky.social @genomicspat.bsky.social · 09/04/2025
Prognostic importance of direct assignment of parent of origin via long-read genome and epigenome sequencing in retinoblastoma
insight.jci.org
JCI Insight - Prognostic importance of direct assignment of parent of origin via long-read genome and epigenome sequencing in retinoblastoma
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genomicspat.bsky.social @genomicspat.bsky.social · 02/04/2025
www.nature.com/articles/s41...
nature.com
An inflammatory biomarker signature of response to CAR-T cell therapy in non-Hodgkin lymphoma - Nature Medicine
A preinfusion circulatory inflammation biomarker-based signature predicts the likelihood of treatment failure in patients with non-Hodgkin lymphoma who were treated with CAR-T cell therapy, with an in...
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genomicspat.bsky.social @genomicspat.bsky.social · 01/04/2025
www.esmoopen.com/article/S205...
esmoopen.com
Prognosis, clinicopathological characteristics, and treatment patterns of patients with ER-intermediate-positive breast cancer undergoing long-term follow-up
Estrogen receptor (ER) expression levels in breast cancer tissue predict the efficacy of endocrine therapy and the prognosis of breast cancer patients. Recently, it was reported that the prognosis of ...
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genomicspat.bsky.social @genomicspat.bsky.social · 31/03/2025
www.science.org/doi/10.1126/...
science.org
An in vivo screen identifies NAT10 as a master regulator of brain metastasis
NAT10 is identified as a master regulator of brain metastasis and a potential target for treating metastasis.
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genomicspat.bsky.social @genomicspat.bsky.social · 28/03/2025
www.biorxiv.org/content/10.1...
biorxiv.org
Inherited resilience to clonal hematopoiesis by modifying stem cell RNA regulation
Somatic mutations that increase hematopoietic stem cell (HSC) fitness drive their expansion in clonal hematopoiesis (CH) and predispose to blood cancers. Although CH frequently occurs with aging, it r...
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genomicspat.bsky.social @genomicspat.bsky.social · 27/03/2025
journals.plos.org/plosone/arti...
journals.plos.org
The role of renal and liver function in clinical ctDNA testing
Circulating tumor DNA (ctDNA) has high clinical potential in early cancer detection. The renal system and the liver are involved in clearing circulating cell free DNA (cfDNA) from the blood. Recent st...
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genomicspat.bsky.social @genomicspat.bsky.social · 27/03/2025
www.sciencedirect.com/science/arti...
sciencedirect.com
Immunophenotype of CAR T cells and apheresis products predicts response in CD22 CAR T cell trial for B cell acute lymphoblastic leukemia
Although CAR T cell therapy is increasingly used to treat relapsed B cell acute lymphoblastic leukemia (ALL), 20%–30% of patients do not respond, and …
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genomicspat.bsky.social @genomicspat.bsky.social · 26/03/2025
www.jmdjournal.org/article/S152...
jmdjournal.org
Deciphering Genomic Complexity of Multiple Myeloma Using Optimized Optical Genome Mapping
The genomic evaluation of multiple myeloma in routine diagnostics involves isolating plasma cells expressing CD138, usually followed by fluorescence in situ hybridization analyses. However, cell sorti...
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genomicspat.bsky.social @genomicspat.bsky.social · 23/03/2025
www.jmdjournal.org/article/S152...
jmdjournal.org
Comparison of targeted RNA sequencing platforms for oncogenic fusion detection in non-small cell lung cancer
Oncogenic fusion detection is an essential part of clinical diagnosis and management of non-small cell lung carcinoma. Numerous methods are available for detection of oncogenic fusions in the clinical...
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genomicspat.bsky.social @genomicspat.bsky.social · 21/03/2025
www.nature.com/articles/s41...
nature.com
γδ T cells as sensors of ectopically expressed intracellular proteins - Cellular & Molecular Immunology
Cellular & Molecular Immunology - γδ T cells as sensors of ectopically expressed intracellular proteins
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genomicspat.bsky.social @genomicspat.bsky.social · 20/03/2025
jhoonline.biomedcentral.com
Second primary malignancies following CAR T-cell therapy in patients with hematologic malignancies - Journal of Hematology & Oncology
Chimeric antigen receptor T-cell (CAR-T) therapy has transformed the management of patients with relapsed/refractory (R/R) hematologic malignancies, including B-cell lymphomas and multiple myeloma (MM...
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genomicspat.bsky.social @genomicspat.bsky.social · 18/03/2025
www.nature.com/articles/s41...
nature.com
Quantitative characterization of cell niches in spatially resolved omics data - Nature Genetics
NicheCompass is a graph variational autoencoder approach for identifying cellular niches defined by cell–cell communication and other interactions, applicable to a broad variety of spatial multi-omic ...
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Reposted by @genomicspat.bsky.social
Elisabetta Bonzano MD, PhD @elisabettabonzano.bsky.social · 14/03/2025
Oncology HERE & NOW Webcast/Podcast Now Out, JOIN OncoAlert Faulty🚨 Dr. @elisaagostinetto.bsky.social 🇧🇪& Dr. @maryamlustberg.bsky.social 🇺🇸 as they dive into #BreastCancer and the use of adj CDK 4/6 inhibitors and more youtu.be/zw8vYd894jI Podcasts : buzzsprout.com/1324033/epis...
youtu.be
Oncology Here & Now Podcast: Breast Cancer with Dr. Maryam Lustberg & Dr. Elisa Agostinetto
YouTube video by OncoAlert 360
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genomicspat.bsky.social @genomicspat.bsky.social · 14/03/2025
nature.com
Long read sequencing enhances pathogenic and novel variation discovery in patients with rare diseases - Nature Communications
Here the authors illustrate how long read whole genome sequencing can enhance the diagnosis of patients with rare diseases relative to standard methods, through identification of comprehensive small a...
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genomicspat.bsky.social @genomicspat.bsky.social · 11/03/2025
nature.com
Cerebrospinal fluid proteomics exerts predictive potential for immune effector cell-associated neurotoxicity syndrome (ICANS) in CAR-T cell therapy - Leukemia
Leukemia - Cerebrospinal fluid proteomics exerts predictive potential for immune effector cell-associated neurotoxicity syndrome (ICANS) in CAR-T cell therapy
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genomicspat.bsky.social @genomicspat.bsky.social · 09/03/2025
jcp.bmj.com/content/78/3...
jcp.bmj.com
Emerging fusion-associated mesenchymal tumours: a tabular guide and appraisal of five ‘novel’ entities
Aims The field of molecular pathology has undergone significant advancements in the clinical impact of sarcoma diagnosis, resulting in challenges to nosology of bone and soft tissue tumours. The surge...
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genomicspat.bsky.social @genomicspat.bsky.social · 06/03/2025
www.nature.com/articles/s41...
nature.com
Dissecting tumor cell programs through group biology estimation in clinical single-cell transcriptomics - Nature Communications
Existing methods for identifying differential gene expression signatures for clinical case/control analyses with high throughput sequencing data present various challenges. Here, the authors develop B...
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genomicspat.bsky.social @genomicspat.bsky.social · 06/03/2025
www.chestnet.org/newsroom/blo...
chestnet.org
Short Telomere Syndrome and Interstitial Lung Disease - American College of Chest Physicians
Get an overview on the connection between short telomere syndrome and interstitial lung disease.
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genomicspat.bsky.social @genomicspat.bsky.social · 03/03/2025
www.pathologyjournal.rcpa.edu.au/article/S003...
pathologyjournal.rcpa.edu.au
A pathologist's guide for the diagnostic workup of paediatric central nervous system tumours
Advances in precision medicine and our understanding of the molecular drivers of central nervous system (CNS) tumorigenesis in children have broadened the scope of diagnostic testing that is required ...
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genomicspat.bsky.social @genomicspat.bsky.social · 27/02/2025
www.nature.com/articles/s41...
nature.com
Synthetic short mRNA prevents metastasis via innate-adaptive immunity - Nature Communications
Extracellular mRNAs are found to play an important role in premetastatic organs. Here this group reports the non-vesicular extracellular IL1β-mRNA complexes binding to ZC3H12D followed by the transloc...
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genomicspat.bsky.social @genomicspat.bsky.social · 27/02/2025
ascopubs.org
Co-Occurrence of Cytogenetic Abnormalities and High-Risk Disease in Newly Diagnosed and Relapsed/Refractory Multiple Myeloma
PURPOSESurvival for patients with multiple myeloma (MM) has improved but outcomes remain heterogeneous. Consistent diagnostic identification of high-risk disease is desirable to address unmet patient ...
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genomicspat.bsky.social @genomicspat.bsky.social · 27/02/2025
nature.com
Whole-genome sequencing analysis identifies rare, large-effect noncoding variants and regulatory regions associated with circulating protein levels - Nature Genetics
Rare variant association analysis of plasma proteins using whole-genome sequencing data in 54,306 individuals in the UK Biobank demonstrates that combining both single-variant and aggregate testing wi...
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genomicspat.bsky.social @genomicspat.bsky.social · 26/02/2025
jmdjournal.org
A Perspective on Artificial Intelligence for Molecular Pathologists
The widespread adoption of next-generation sequencing technology in molecular pathology has enabled us to interrogate the genome as never before. The huge quantities of data generated by sequencing, t...
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genomicspat.bsky.social @genomicspat.bsky.social · 25/02/2025
ashpublications.org/blood/articl...
ashpublications.org
Defining pathogenic IL-17 and CSF-1 gene expression signatures in chronic graft-versus-host disease
Key Points. Temporal single cell RNA sequencing of mouse blood identifies non-intuitive signatures of IL-17 and CSF-1 dysregulation during chronic GVHD.Ana
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Reposted by @genomicspat.bsky.social
Tal Laviv @lavivtal.bsky.social · 20/02/2025
I started my lab more then 4 years ago, and we have endured some very challenging times ever since.…I am very excited to share the first paper from my lab, published now in @naturemethods.bsky.social www.nature.com/articles/s41...
nature.com
Genetically encoded biosensor for fluorescence lifetime imaging of PTEN dynamics in the intact brain - Nature Methods
A first-in-class fluorescence lifetime-based FRET sensor for phosphatase and tensin homolog (PTEN) enables the dynamic monitoring of PTEN activity in cultured cells and in vivo with high spatiotempora...
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Reposted by @genomicspat.bsky.social
bioRxiv Genomics @biorxiv-genomic.bsky.social · 20/02/2025
The mutational and clonality profile of HGSOC is established early in tumor development and conserved throughout therapy resistance www.biorxiv.org/content/10.1101/202…
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Reposted by @genomicspat.bsky.social
Richard Branson @richardbranson.bsky.social · 20/02/2025
President Zelenskyy has been one of the greatest leaders of our time, guiding Ukraine through the darkest period of its recent history, rising up to Russia’s unwarranted aggression, being an inspiration to the Ukrainian people and ensuring that Ukraine’s voice is heard on the world stage.
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Reposted by @genomicspat.bsky.social
Sarah Ross @sarahhross.bsky.social · 20/02/2025
#Immunology out now @science.org Machine learning, using the sequences of an individual's B and T cell receptors, has the potential to diagnose immune-related diseases. buff.ly/3QvxSVf By Maxim Zaslavsky, Erin Craig, @anshulkundaje.bsky.social , @scottboydlab.bsky.social et al.
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genomicspat.bsky.social @genomicspat.bsky.social · 20/02/2025
jamanetwork.com/journals/jam...
jamanetwork.com
Endocrine Therapy Interruption, Resumption, and Outcomes Associated With Pregnancy After Breast Cancer
This cohort study examines interruption and resumption of endocrine therapy among women with breast cancer who became pregnant.
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genomicspat.bsky.social @genomicspat.bsky.social · 20/02/2025
pubmed.ncbi.nlm.nih.gov/39966346/
pubmed.ncbi.nlm.nih.gov
Clonal plasma cell proportion in the synthetic phase identifies a unique high-risk cohort in multiple myeloma - PubMed
Risk stratification models based on cytogenetics and disease burden help identify high-risk patients with newly diagnosed multiple myeloma (NDMM). However, some high-risk patients remain undetected. T...
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genomicspat.bsky.social @genomicspat.bsky.social · 20/02/2025
www.globenewswire.com/news-release...
globenewswire.com
Press Release Biocartis NV: Biocartis announces new data on early CAR-T vector load assessment with Idylla™ presented at ASTCT: A Potential Breakthrough in LBCL Treatment Monitoring
PRESS RELEASE - 14/02/2025, 09:30 CET Biocartis announces new data on early CAR-T vector load assessment with Idylla™ presented at ASTCT: A Potential...
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genomicspat.bsky.social @genomicspat.bsky.social · 19/02/2025
www.biorxiv.org/content/10.1...
biorxiv.org
Functional memory T cells are derived from exhausted clones and expanded by checkpoint blockade
Immune checkpoint blockade can facilitate tumor clearance by T cells, resulting in long term patient survival. However, the capacity of exhausted CD8+ T cells (Tex), present during chronic antigen exp...
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genomicspat.bsky.social @genomicspat.bsky.social · 01/02/2025
www.cell.com/cell-reports...
cell.com
The T cell receptor sequence influences the likelihood of T cell memory formation
The human immune system contains a vast repertoire of somatically recombined T cell receptor (TCR) sequences. To connect TCR sequence to T cell function, Lagattuta et al. analyze the paired αβTCR and ...
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genomicspat.bsky.social @genomicspat.bsky.social · 31/01/2025
ashpublications.org
Optical genome mapping identified deletions, inversions, and insertions in hemophilia
TO THE EDITOR:
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genomicspat.bsky.social @genomicspat.bsky.social · 30/01/2025
aacrjournals.org/bloodcancerd...
aacrjournals.org
The Crossroads of Clonal Evolution, Differentiation Hierarchy, and Ontogeny in Leukemia Development
Abstract. Transformative technologies to sequence tumor genomes at large scale and single-cell resolution have exposed the repertoire of genetic alterations that are present in leukemia genomes, the t...
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genomicspat.bsky.social @genomicspat.bsky.social · 27/01/2025
medpagetoday.com
Practice-Changing Win for Aspirin in Colorectal Cancer
Recurrence rate in early-stage disease reduced by 50-60% in patients with PI3K pathway mutations
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genomicspat.bsky.social @genomicspat.bsky.social · 27/01/2025
acsjournals.onlinelibrary.wiley.com
POLE mutations in endometrial carcinoma: Clinical and genomic landscape from a large prospective single‐center cohort
This comprehensive genomic analysis of 596 patients with endometrial cancer investigated the characteristics of DNA polymerase epsilon (POLE) mutations. The results revealed no significant genomic di...
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genomicspat.bsky.social @genomicspat.bsky.social · 25/01/2025
onlinelibrary.wiley.com
Efficacy of anti‐PD1 therapy in extranodal NK/T cell lymphoma: A matched cohort analysis from the LYSA
Click on the article title to read more.
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genomicspat.bsky.social @genomicspat.bsky.social · 24/01/2025
youtu.be
Stratos Genomics- Sequencing by Expansion
YouTube video by Dikajob Social Network
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Reposted by @genomicspat.bsky.social
The OncoAlert Network 🚨 @oncoalert.bsky.social · 23/01/2025
Dear Colleagues The OncoAlert🚨 Network and our partners invite you to the #OncoAlertColloquium REGISTER for FREE HERE👉 buff.ly/3CChgre February 3-9, 2025 💯% Virtual & Interactive Watch Our #BreastCancer Faculty @matteolambe 🇮🇹 of @UniGenova Presenting on #Fertility Preservation
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