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Jared Mohr

@fourmohryears.bsky.social
609 followers 373 following 12 posts

Chemical cross-linking and mass spectrometry technology development.

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Jared Mohr @fourmohryears.bsky.social · 24/03/2026
That's why you always follow your heart
media.tenor.com
a cartoon coyote is riding a skateboard with a magnet attached to it
ALT: a cartoon coyote is riding a skateboard with a magnet attached to it
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Reposted by Jared Mohr
PRIDE Database @pride-ebi.bsky.social · 15/01/2026
PXD058490 🚨 Quantitative chemical cross-linking of live cells, organelles, or tissues together with mass spectrometry provides a new insight on protein conformational plasticity within organisms, cells, and tissues. 🚨 New dataset alert! 🚨
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Reposted by Jared Mohr
UW Genome Sciences @uwgenome.bsky.social · 12/11/2025
Congratulations to Mike MacCoss on receiving the Donald F. Hunt Distinguished Contribution in Proteomics Award from US HUPO! us-hupo.org/Distinguishe...
us-hupo.org
US HUPO - Distinguished Contribution Award
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Reposted by Jared Mohr
Phil Leung @proleu.bsky.social · 05/11/2025
Glad to see our antibody design paper finally out in @nature.com (and congrats to lead authors and everyone involved )! At Xaira we are excited about pushing antibody design further to bind harder targets and make drugs for unmet medical needs. Paper: www.nature.com/articles/s41...
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Jared Mohr @fourmohryears.bsky.social · 03/11/2025
Tears are the best solvent to get pump oil off the optics, hope that helps
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Ruth Huttenhain @rhuttenhain.bsky.social · 02/10/2025
My lab @stanfordmedicine.bsky.social is recruiting! We are looking for a postdoc at the interface of quantitative proteomics and G protein-coupled receptor (GPCR) biology: postdocs.stanford.edu/prospective/... #TeamMassSpec #Proteomics #GPCR #Postdoc
postdocs.stanford.edu
Open Postdoctoral position, faculty mentor Ruth Huttenhain | Office of Postdoctoral Affairs
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Jared Mohr @fourmohryears.bsky.social · 11/09/2025
media.tenor.com
a man says do you think god stays in heaven because he too lives in fear of what he 's created ?
ALT: a man says do you think god stays in heaven because he too lives in fear of what he 's created ?
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Reposted by Jared Mohr
Francis O'Reilly @fjoreilly.bsky.social · 05/08/2025
‼️ Exciting new preprint from a close collaboration with Kylie Walters' group. Our study maps the binding sites of key regulators of the proteasome in situ. www.biorxiv.org/content/10.1...
biorxiv.org
Structures of dynamic interactors at native proteasomes by PhIX-MS and cryoelectron microscopy
Proteasome function depends on a network of transient interactions that remain structurally and functionally unresolved. We developed PhIX-MS (Photo-induced In situ Crosslinking-Mass Spectrometry), a ...
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Reposted by Jared Mohr
Andrea Sinz 🧪 @sinzandrea.bsky.social · 25/06/2025
‼️ Job alert 🚨: I have an open 3-year postdoc position in my lab to develop novel crosslinking mass spectrometry workflows. 🧪🧪 So if you want to do cool stuff in protein MS, please apply ! ⬇️ Please RT www.verwaltung.uni-halle.de/dezern3/Auss... #Academicsky #Chemsky #teammassspec
verwaltung.uni-halle.de
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Reposted by Jared Mohr
Mike Goodwin @massspecpro.bsky.social · 12/06/2025
RIP Alan Marshall, one of the greatest mass spectrometrists ever, and a great human to boot. nationalmaglab.org/careers/meet...
nationalmaglab.org
Alan Marshall: A scientist and a Gentleman - MagLab
Meet one of the greatest innovators in the history of mass spectrometry, hard at work.
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Jared Mohr @fourmohryears.bsky.social · 08/04/2025
The tutorials/demos that are packed with SIMION are a pretty good starting point. They have some examples of the lua code for RF and other time dependent fields. Pretty sure there's a simple quad demo that would be a good starting point for a trap
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PastelBio @pastelbio.bsky.social · 24/03/2025
Large-Scale Quantitative Cross-Linking and Mass Spectrometry Provide New Insight into Protein Conformational Plasticity within Organelles, Cells, and Tissues pubs.acs.org/doi/10.... --- #proteomics #prot-paper
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Jared Mohr @fourmohryears.bsky.social · 20/03/2025
I met Michelle Heck at the plant pathology dept chili cook off when I was an undergrad and she was looking for a new student to learn to run her TSQ Vantage. Then I met her collaborator Jim Bruce when he gave a talk on campus a few months later and he offered me a summer job as a tech at UW
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Jared Mohr @fourmohryears.bsky.social · 06/03/2025
We had built something conceptually similar using the front lens on an ICR (or adjacent quad segments) in a segmented PCB quad to trap ions between the LIT and ICR cell on our development instrument to improve trapping for short ICR array cells. Nightmarish to optimize timings, very impressive work
analyticalsciencejournals.onlinelibrary.wiley.com
A planar quadrupole device for transmitting and trapping ions in high vacuum
Rationale Hybrid mass spectrometers combine multiple mass analyzers to achieve optimal performance in terms of tandem mass spectrometry, high mass resolving power, and mass measurement accuracy for ...
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Reposted by Jared Mohr
Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 18/02/2025
Excited to share this new work led by postdoc Brendan Floyd, deep mapping of cell-surface protein interactomes of T and B cells reveals maverick mitochondrial proteins and immune modulatory complexes. www.biorxiv.org/content/10.1...
biorxiv.org
Mapping the nanoscale organization of the human cell surface proteome reveals new functional associations and surface antigen clusters
The cell surface is a dynamic interface that controls cell-cell communication and signal transduction relevant to organ development, homeostasis and repair, immune reactivity, and pathologies driven b...
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Reposted by Jared Mohr
Andrea Sinz 🧪 @sinzandrea.bsky.social · 07/02/2025
Job alert 🧪 ‼️ Hi #teammassspec: In our #RTG2467 @unihalle.bsky.social we have a job opening for a PhD student in my group! 🎉 If you want to do cool stuff in cross-linking mass spectrometry of the tumor suppressor p53, please take a look: personal.verwaltung.uni-halle.de/jobs/wissmi/ Please RT!
personal.verwaltung.uni-halle.de
Externe Stellenausschreibungen- Wissenschaftliche Mitarbeiterinnen und Mitarbeiter, Ärzte und Lehrkräfte für besondere Aufgaben
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Jared Mohr @fourmohryears.bsky.social · 06/12/2024
I am a mass spectrometrist only because I was fortunate enough to meet Michelle at a chili cook off in 2014
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Females in Mass Spectrometry (FeMS+) @femalesinms.bsky.social · 30/11/2024
Hi #TeamMassSpec! #FeMS+ has joined BlueSky! Please share and get the word out so we can build up a base here.
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Jared Mohr @fourmohryears.bsky.social · 01/02/2024
You can install on anything, the software docs have minimum hardware specs but they're pretty light . There is a correct order to install them in - usually foundation, xcal, tune.
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Jared Mohr @fourmohryears.bsky.social · 26/01/2024
Compute goes brrrrr
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Jared Mohr @fourmohryears.bsky.social · 04/01/2024
Last bit of my PhD work, a four-armed cross-linker (Bisby) prepared by SPPS and a real-time ms3 targeting method written in ITCL based on Chad's original ReACT implementation running on our Velos-FTICR with mito samples from long-time collaborator Arianne.
pubs.acs.org
Multidimensional Cross-Linking and Real-Time Informatics for Multiprotein Interaction Studies
Chemical cross-linking combined with mass spectrometry is a technique used to study protein structures and identify protein complexes. Traditionally, chemical cross-linkers contain two reactive groups...
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Reposted by Jared Mohr
PastelBio @pastelbio.bsky.social · 27/12/2023
Multidimensional Cross-Linking and Real-Time Informatics for Multiprotein Interaction Studies pubs.acs.org/doi/10.... --- #proteomics #prot-paper
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Jared Mohr @fourmohryears.bsky.social · 15/12/2023
There is a common problem specifically on QE+ interfaced with Waters LCs that causes contact closures from the MS to get fired early that leads to weird things like runs getting closed out early. Can be fixed by configuring the LC to supply cc to the MS instead of vice versa.
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Jared Mohr @fourmohryears.bsky.social · 21/11/2023
The shiny side is only coated if you buy a non-stick foil? Shouldn't matter for normal foil, the shiny side is a manufacturing artifact because only one face touches the roller.
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