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Florian I. Schmidt lab

@fischmidtlab.bsky.social

164 followers 200 following 17 posts

Cell Biology meets Immunology and Virology, spiced up with nanobodies

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Florian I. Schmidt lab @fischmidtlab.bsky.social · 23/05/2026

If you are interested in molecular regulation of innate immunity or nanobody technology, we have a few exciting postoc positions to fill in the Schmidt lab @unibonn.bsky.social in the context of @immunosens.bsky.social. Please share!

Postdoc positions in molecular immunology and nanobody technology in the Schmidt lab at Uni Bonn, Germany

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Florian I. Schmidt lab @fischmidtlab.bsky.social · 23/05/2026

If you are interested in molecular aspects of innate immunity or nanobody technology, we have a few exciting postdoc positions to fill in the Schmidt lab @unibonn.bsky.social in the context of @immunosens.bsky.social. Please share!

Postdoc position in Molecular Immunology and Nanobody Technology in the Schmidt lab at Uni Bonn, Germany

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Florian I. Schmidt lab @fischmidtlab.bsky.social · 12/03/2026

The #BonnOrganoidSymposium 2026 with a fantastic talk by @microorganolab.bsky.social on the diverse applications of #organs-on-chip and #organoids

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Florian I. Schmidt lab @fischmidtlab.bsky.social · 12/03/2026

… getting started

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Florian I. Schmidt lab @fischmidtlab.bsky.social · 12/03/2026

Ready for the #BonnOrganoidSymposium 2026 at @unibonn.bsky.social ….

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Florian I. Schmidt lab @fischmidtlab.bsky.social · 29/01/2026

Early weekend read: Our new review on #antiviral #inflammasomes spearheaded by Jennifer Wuerth with some recommendations for inflammasome detection is out! @unibonn.bsky.social @immunosens.bsky.social www.mdpi.com/1999-4915/18...

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Florian I. Schmidt lab @fischmidtlab.bsky.social · 21/01/2026

... and engineered reporter poxviruses to impair AIM2 inflammasomes in human primary cells with inhbitory nanobodies, revealing that primary macrophages and keratinocytes assemble #AIM2 inflammasomes, while monocytes assemble #NLRP3 inflammasomes.

Recombinant viruses encode inflammasome reporter caspase-1 CARD-EGFP and inhibitory AIM2 nanobodies, which block inflammasome assembly in macrophages, but not monocytes.

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Florian I. Schmidt lab @fischmidtlab.bsky.social · 21/01/2026

... identified #nanobodies that block AIM2 inflammasomes by interfering with AIM2 Pyrin filament oligomerization (sequences deposited in nanosaurus.org data base) ...

While overexpression of AIM2 PYD-EGFP assembles filaments, co-expression of AIM2 nanobodies blocks filament formation and inflammasome asssembly

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Florian I. Schmidt lab @fischmidtlab.bsky.social · 21/01/2026

We constructed reporter poxviruses to track inflammasome assembly in human primary cells ....

Infected human primary macrophages and monocytes undergo pyroptosis and assemble inflammasomes.

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Florian I. Schmidt lab @fischmidtlab.bsky.social · 17/06/2025

First talk by Christian Liemersdorf from @dlr-de.bsky.social about organoid in space - great fun at full house (first time I have seen every single spot of the lecture hall taken)

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Florian I. Schmidt lab @fischmidtlab.bsky.social · 17/06/2025

Thrilled to start the 2nd Bonn #Organoid Day with more than 100 participants at @unibonn.bsky.social!

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Florian I. Schmidt lab @fischmidtlab.bsky.social · 06/04/2025

Late #WeekendRead: We describe a novel reporter to visualize endogenous #inflammasome assembly. Suitable for cell lines, primary cells, and tissues as well as quantification by #microscopy and #flowcytometry. Happy to share. www.biorxiv.org/content/10.1...

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