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Fischer-Friedrich Lab

@fischerfriedriclab.bsky.social
139 followers 78 following 25 posts

We are a research lab in the Cluster of Excellence Physics of Life at the Technische Universität Dresden. Our interests are cell mechanics, cell biology and atomic force microscopy and modelling.

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Fischer-Friedrich Lab @fischerfriedriclab.bsky.social · 03/07/2026
Here you go: journals.aps.org/prx/pdf/10.1...
journals.aps.org
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Physics of Life Dresden @poldresden.bsky.social · 27/05/2026
🤔 How do mechanical forces shape the behavior and organization of living matter? 👩‍🔬Understanding how these forces influence material properties, molecular composition, and biological function is a key focus of the @fischerfriedriclab.bsky.social at Physics of Life. Learn more👉 youtu.be/1bzjPVxlAf4
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Physics of Life Dresden @poldresden.bsky.social · 22/04/2026
Starting our second phase at Physics of Life Dresden full of energy! ⚡️But who are we, and what is our research about? 🎥We are releasing a series of exciting short films to answer these questions and more 🎬 Curious? Check them out🤓 Full video on YouTube: www.youtube.com/watch?v=nHm6... Part 1/2
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Physics of Life Dresden @poldresden.bsky.social · 11/02/2026
Here's a beautiful #microscopy image from our PoL Photo Competition 📸 👨‍🔬 🔬©️ Image taken by Yogishree Arabinda Panda, PhD student in the Fischer-Friedrich group @fischerfriedriclab.bsky.social 🔍 Caption: A SEM micrograph of a mitotically arrested HeLa cell with visible filopodia membrane reservoirs
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Fischer-Friedrich Lab @fischerfriedriclab.bsky.social · 24/04/2026
#jobalert - We are looking for an experimental #Postdoc to join our group and work on exciting questions in #Mechanobiology - prospectively starting 09/2026. The ideal candidate has experience in #microscopy, quantitative image analysis, coding. Get in touch if you would like to know more.
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Benjamin Friedrich @friedrich-group.bsky.social · 26/02/2026
Just published: chemotactic sperm cells become phototactic 💡- by loading photo-activatable second messengers. This allows to "reverse-engineer" chemotactic signaling dynamics and expose cells to signals they would never see in the wild. Honoured to be part of this collaboration with the Kaupp lab.
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Fischer-Friedrich Lab @fischerfriedriclab.bsky.social · 09/01/2026
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Fischer-Friedrich Lab @fischerfriedriclab.bsky.social · 08/01/2026
www.cell.com/current-biol...
cell.com
Extracellular matrix restrains cell-cycle progression by nuclear exclusion of Yorkie in Drosophila
Sui et al. reveal a role for extracellular matrix in restraining cell-cycle progression in late-larval-stage Drosophila wing discs through inhibiting nuclear accumulation of Yorkie.
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Fischer-Friedrich Lab @fischerfriedriclab.bsky.social · 08/01/2026
ECM as a cell-cycle brake. Led by Liyuan Sui (Dahmann lab), we show that the ECM gates Yorkie nuclear entry to halt proliferation at final size via G2 arrest in the Drosophila wing disc. Programmed ECM degradation later enables re-entry + proper adult wing size. Link 👇 #Mechanobiology #ECM
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Fischer-Friedrich Lab @fischerfriedriclab.bsky.social · 08/01/2026
The New Scientist published a commentary article: www.newscientist.com/article/2505...
newscientist.com
We may need a fourth law of thermodynamics for living systems
The laws of thermodynamics don't accurately account for the complex processes in living cells – do we need a new one to accurately measure the ways living systems are out of equilibrium?
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Fischer-Friedrich Lab @fischerfriedriclab.bsky.social · 08/01/2026
link.aps.org/doi/10.1103/...
link.aps.org
Time Irreversibility, Entropy Production, and Effective Temperature Are Independently Regulated in the Actin Cortex of Living Cells
Atomic force microscope observations of dividing human cells suggest that effective temperature alone cannot reliably gauge how far a living system is from equilibrium.
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Fischer-Friedrich Lab @fischerfriedriclab.bsky.social · 08/01/2026
New paper out: AFM-tip fluctuations inside the actin cortex reveal that effective temperature can remain unchanged while time-irreversibility/entropy production drop (turnover inhibition). #CellMechanics #ActiveMatter #Nonequilibrium @poldresden.bsky.social @tudresden.bsky.social
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Fischer-Friedrich Lab @fischerfriedriclab.bsky.social · 08/01/2026
New paper out: AFM-tip fluctuations inside the actin cortex reveal that effective temperature can remain unchanged while time-irreversibility/entropy production drop (turnover inhibition). #CellMechanics #ActiveMatter #Nonequilibrium @poldresden.bsky.social @tudresden.bsky.social
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Benjamin Friedrich @friedrich-group.bsky.social · 20/12/2025
🏋️Our review on how to build muscle is out in @biophysicalreviews.bsky.social: The Physical Basis of Sarcomere Assembly. We critically review past models and discuss a new mechanism that unifies past ideas, suggesting tension-driven self-organization. With @frankschnorrer.bsky.social & Kolley-Köchel
The sarcomere is the elementary contractile unit of muscle, driving all volunatry motion and heart beat in animals. How these “cytoskeletal crystals” self-assembly is only partly understood.
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Benjamin Friedrich @friedrich-group.bsky.social · 26/11/2025
Axolotl can regrow lost limbs, matching their body size. How? Our new theory-experiment paper in @pnas.org proposes how oppositely oriented morphogen gradients scaling with animal size promote proportional growth. Great collaboration with @tatianasg.bsky.social @cmcb-tud.bsky.social
Schematic of limb regeneration in axolotl, with growth controlled by two oppositely oriented morphogen gradients (SHH, FGF8).
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Fischer-Friedrich Lab @fischerfriedriclab.bsky.social · 10/11/2025
Find the link here www.bruker.com/en/landingpa...
bruker.com
Episode 6: The Role of Mechanical Forces in Health and Disease feat. Prof. Dr. Elisabeth Fischer-Friedrich
Join Prof. Elisabeth Fischer-Friedrich from the Cluster of Excellence 'Physics of Life' at the Technical University Dresden, Germany, as she speaks about the role of mechanical forces in health and di...
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Fischer-Friedrich Lab @fischerfriedriclab.bsky.social · 10/11/2025
Interested in #mechanobiology? I joined Bruker’s Conversations on AFM to discuss how mechanical forces shape #cells and #tissues, what #AFM can reveal, and why mechanics matters for health and disease. @poldresden.bsky.social @tudresden.bsky.social
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Fischer-Friedrich Lab @fischerfriedriclab.bsky.social · 22/10/2025
You wanna know more about what Gina discovered with respect to MET? Find the full story here: www.sciencedirect.com/science/arti...
sciencedirect.com
Mesenchymal-epithelial transition reduces proliferation but increases immune evasion in tumor spheroids
The mesenchymal-epithelial transition (MET) whether full or partial, has been implicated in secondary tumor growth during metastasis. Here, we explore…
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Fischer-Friedrich Lab @fischerfriedriclab.bsky.social · 22/10/2025
Congrats to our latest graduate Gina Dimari 🤩🥳💐@fischerfriedriclab.bsky.social @poldresden.bsky.social freshly graduated @tudresden.bsky.social faculty of Biology. Thanks to everyone involved in the project recently published @cp-iscience.bsky.social
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Fischer-Friedrich Lab @fischerfriedriclab.bsky.social · 03/08/2025
How do individual proteins sculpt the epithelial basement membrane? Our new study uncovers their role in network structure, nematic alignment & fractal patterns. 🔗 www.sciencedirect.com/science/arti... #CellBiology #ECM #BasementMembrane
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Fischer-Friedrich Lab @fischerfriedriclab.bsky.social · 03/08/2025
Why do secondary #tumors go for #MET during the metastatic cascade? Our new study suggests that immune evasion—rather than faster proliferation—might give them the edge. 👉 cell.com/iscience/ful... #CancerResearch #TumorBiology #Immunology #Metastasis
cell.com
Mesenchymal-epithelial transition reduces proliferation but increases immune evasion in tumor spheroids
Microenvironment; Biological process; Cancer
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Fischer-Friedrich Lab @fischerfriedriclab.bsky.social · 06/05/2025
Here is the link physics-of-life.tu-dresden.de/career-educa...
physics-of-life.tu-dresden.de
PoL – Physics of Life | Career & Education | MSc Physics of Life
Physics of Life: Discover new paradigms for understanding life and deepen our knowledge of living biological matter
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Fischer-Friedrich Lab @fischerfriedriclab.bsky.social · 06/05/2025
🎉 Calling all #Physics undergrads! We're offering 3 scholarships for the tuition-free, English-taught MSc "Physics of Life" @TUDresden, starting Oct 2025. 💶 €300/month for 12 months Apply now! #Scholarships #Masters2025 #PhysicsOfLife #StudyInGermany #TUDresden
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Fischer-Friedrich Lab @fischerfriedriclab.bsky.social · 14/04/2025
Check it out if you are interested in #mechanobiology #membranetension #cytoskeleton #FlipperTR
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Fischer-Friedrich Lab @fischerfriedriclab.bsky.social · 10/04/2025
#Biophysics #PhysicsStudent #Physics #Biology #Mechanobiology
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Rita Mateus @ritamateus.bsky.social · 09/04/2025
Super proud of superstar postdocs @nerlielisa.bsky.social and @liujinghui.bsky.social for our lab's most recent preprint! We uncover how wound-induced electrical currents are generated and transmitted in tissues, triggering proliferation, essential for organ #regeneration #bioelectricity #QBio 👇
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Ulrich Schwarz @ulrichschwarz.bsky.social · 10/04/2025
📢 Preprint alert 📢 (1/6) Our work on 3D force inference for intestinal organoids is now on bioRxiv: www.biorxiv.org/content/10.1... Stunning collaboration between @omdrozdowski.bsky.social and @kimboonekamp.bsky.social from the lab of @michaelboutros.bsky.social and with Ulrike Engel. A short🧵...
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Fischer-Friedrich Lab @fischerfriedriclab.bsky.social · 10/04/2025
👉 physics-of-life.tu-dresden.de/career-educa...
physics-of-life.tu-dresden.de
PoL – Physics of Life | Career & Education | MSc Physics of Life
Physics of Life: Discover new paradigms for understanding life and deepen our knowledge of living biological matter
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Fischer-Friedrich Lab @fischerfriedriclab.bsky.social · 10/04/2025
🎉 Exciting news for incoming students! We're awarding 3 scholarships for the Physics of Life MSc program starting October 2025. 💶 €300/month for one year 🎓 Funded by the Friends & Supporters of TU Dresden (GFF) #Scholarships #Masters2025 #PhysicsOfLife #TUDresden #StudyFunding
physics-of-life.tu-dresden.de
PoL – Physics of Life | Career & Education | MSc Physics of Life
Physics of Life: Discover new paradigms for understanding life and deepen our knowledge of living biological matter
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Fischer-Friedrich Lab @fischerfriedriclab.bsky.social · 10/04/2025
🚀 Looking for a Master’s at the interface of physics and biology? Join the Physics of Life MSc program in Dresden! 🔬 Cutting-edge research 🌍 Affordable living 🎯 Excellent career prospects—in science and beyond.
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Fischer-Friedrich Lab @fischerfriedriclab.bsky.social · 02/04/2025
Surprised by how long it’s taking PNAS to process our manuscript. Anyone else having trouble recently? #AcademicTwitter #Publishing
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Fischer-Friedrich Lab @fischerfriedriclab.bsky.social · 27/03/2025
It’s the #filopodia, stupid! 🚀 We just released our new study uncovering how filopodia and hydrostatic #pressure contribute to the regulation of #membrane #tension. 👉 Check it out on bioRxiv: biorxiv.org/content/10.1... #cellbiology #biophysics #actin #mechanobiology
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Fischer-Friedrich Lab @fischerfriedriclab.bsky.social · 09/03/2025
🚀 Looking for an #HFSP ally? We’ve got you covered with #AtomicForceMicroscopy, #CellCulture, #Mechanobiological #Modeling, & more! 🤝 Interested? Let’s connect! 📧 Details 👉 physics-of-life.tu-dresden.de #Collaboration
physics-of-life.tu-dresden.de
PoL – Physics of Life | Team | PoL Groups | Elisabeth Fischer-Friedrich
Physics of Life: Discover new paradigms for understanding life and deepen our knowledge of living biological matter
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Fischer-Friedrich Lab @fischerfriedriclab.bsky.social · 04/02/2025
It turns out that #EggChamber #elongation and rotation can be decoupled in #Drosophila egg chamber #morphogenesis - check out our recent collaborative work with the Dahmann lab. journals.biologists.com/dev/article/... . Congrats to Akanksha Bhatt and Valentin Ruffine 👏🥳
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