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faurelab.bsky.social

@faurelab.bsky.social
678 followers 201 following 43 posts

Neuroscience lab. We study decision making, exploration and addiction. We are interested in inter-individual variability.

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Nicolas Guyon @nicolasguyon.bsky.social · 24/07/2026
New work from our lab @faurelab.bsky.social expending the tools available to study nicotinic receptors more precisely. @espciparispsl.bsky.social @psl-univ.bsky.social
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fjmeye.bsky.social @fjmeye.bsky.social · 04/04/2026
Our new study on neurobiology of stress-driven food intake. www.nature.com/articles/s41... In mice, PFC controls lateral hypothalamus through a multi-branched network. Stress causes differential plasticity across branches, priming the network to promote bingeing. #stresseating
nature.com
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faurelab.bsky.social @faurelab.bsky.social · 02/04/2026
Thanks to the whole team and in particular to @clementsolie.bsky.social who drove this work from the ground up, and to Bruno Delord ( @ISIR - Institut des Systèmes Intelligents et de Robotique), for developing the computational models that gave it its theoretical backbone.
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faurelab.bsky.social @faurelab.bsky.social · 02/04/2026
See also @cnrs.fr press release www.cnrs.fr/fr/presse/le..., (thanks to Aurélie Meilhon). It would not have been possible without the work of the whole team at @espciparispsl.bsky.social, @cnrsbiologie.bsky.social , @cnrs.fr
lnkd.in
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faurelab.bsky.social @faurelab.bsky.social · 02/04/2026
Yet the relationship is bidirectional – and this is where it gets very interesting: manipulating dopamine activity before the social experience reshapes the entire group structure. A social role is not a stable trait — it is a dynamic position within a collective system.
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faurelab.bsky.social @faurelab.bsky.social · 02/04/2026
Striking sex-dependence. Male triads develop worker-scrounger specialisation driven by competition. Female triads remain homogeneous with almost all individuals adopting storer profiles. Introduce one male into a female group and specialisation emerges, including in the females.
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faurelab.bsky.social @faurelab.bsky.social · 02/04/2026
Striking sex-dependence. Male triads develop worker-scrounger specialization driven by competition. Female triads remain homogeneous with almost all individuals adopting storer profiles. Introduce one male into a female group and specialization emerges, including in the females.
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faurelab.bsky.social @faurelab.bsky.social · 02/04/2026
These roles emerge from the interplay between individual predispositions – tendency to explore versus exploit – and the contingency of early social interactions. The same individual, in a different group, will adopt a different role. Social context is not a backdrop; it is a cause.
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faurelab.bsky.social @faurelab.bsky.social · 02/04/2026
Using behavioral tracking, neural recordings and modeling, we found 3 distinct roles emerging spontaneously: Workers, who produce food ; Scroungers, who exploit the efforts of others; and Storers, who press the lever frequently but delay food retrieval, remaining outside the competitive dynamic.
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faurelab.bsky.social @faurelab.bsky.social · 02/04/2026
New paper in Nature, @nature.com (go.nature.com/4c4OjCj) : how do social roles emerge in groups of near-identical individuals ? we find that they are neither predetermined nor fixed.
go.nature.com
Dopaminergic mechanisms of dynamical social specialization - Nature
Longitudinal tracking of mice reveals that stable, specialized social roles emerge spontaneously within groups during a foraging task, with dopaminergic activity in the ventral tegmental area driving ...
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faurelab.bsky.social @faurelab.bsky.social · 27/02/2026
4/4 Without any explicit “context” label, a neural-network RL agent trained by TD learning reproduces both rule-specific strategies and the remapping. This suggests remapping can emerge from standard learning dynamics via representation change. So remapping may be an emergent property.
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faurelab.bsky.social @faurelab.bsky.social · 27/02/2026
3/4 Instead, DA signals are best captured by different RPE-like variables computed over the currently learned action representation, not one fixed RPE. In short: the “error” DA reports changes with how the animal is currently defining the action.
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faurelab.bsky.social @faurelab.bsky.social · 27/02/2026
2/4 Same movements, different reward rules in the same mouse. In a self-paced 3-target foraging task in freely moving mice, nucleus accumbens dopamine (fiber photometry) shows rule-dependent remapping. Model comparison suggests a fixed, representation-invariant RPE can’t explain DA across rules.
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faurelab.bsky.social @faurelab.bsky.social · 27/02/2026
1/4 When rules change, dopamine (DA) changes what it calls an “action”. New bioRxiv version: “Dopamine tracks adaptive learning of action representations”. www.biorxiv.org/content/10.1... This project brought together Maxime Come’s PhD work and Arnaud Lespart’s postdoctoral work in our lab.
biorxiv.org
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faurelab.bsky.social @faurelab.bsky.social · 09/01/2026
Congratulations Lauren
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Reposted by @faurelab.bsky.social
Antoine Bergel @antbergel.bsky.social · 29/12/2025
⚠️ New paper alert and what a way to end 2025! 🎉 Happy to share our story “Sleep-dependent infraslow rhythms are evolutionarily conserved across reptiles and mammals.” published today in Nature Neuroscience. Sleeping dragons 🦎 and functional ultrasound! Read the full paper here: rdcu.be/eWJHb 1/8
rdcu.be
Sleep-dependent infraslow rhythms are evolutionarily conserved across reptiles and mammals
Nature Neuroscience - Bergel et al. show that an infraslow rhythm connecting the brain and body during sleep is shared by lizards, mammals and birds, revealing an ancestral process and reshaping...
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faurelab.bsky.social @faurelab.bsky.social · 10/12/2025
Congrats, well deserve
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Emmanuel Perisse @manuperisse.bsky.social · 15/09/2025
You just finished your PhD and you are looking for a postdoc to study stress-dependent modulation of learning. We are using the powerful fly model to understand the underlying circuits and mechanisms. You can apply here: emploi.cnrs.fr/Offres/CDD/U...
emploi.cnrs.fr
Portail Emploi CNRS - Offre d'emploi - Postdoc position (M/F) in Neuroscience, stress modulation of learning (H/F)
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faurelab.bsky.social @faurelab.bsky.social · 17/09/2025
Big news for @laurenmac.bsky.social ! 2025 is quite a year: CNRS position + ERC Starting Grant Her project DeMARRe will study how adolescent exploration & risk-taking shape neural circuits and resilience in adulthood. @cnrs.fr @espciparispsl.bsky.social www.insb.cnrs.fr/fr/personne/...
insb.cnrs.fr
Lauren Reynolds
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katja heuer @k4tj4.bsky.social · 27/07/2025
1 To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised! 🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...
Brain Surfaces of 70 primate species
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CNRS Biologie @cnrsbiologie.bsky.social · 10/07/2025
Alcool et nicotine : un même circuit cérébral à l’origine de la récompense et de l’anxiété 👋 @cnrs-paris.bsky.social @espciparispsl.bsky.social ✍️ @faurelab.bsky.social & Fabio Marti 👉 Lire l'article dans buff.ly/vE1j6LP buff.ly/fD5DOxu
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faurelab.bsky.social @faurelab.bsky.social · 05/07/2025
Congratulations to first author Tinaïg Le Borgne for her outstanding work and Fabio marti for leading this project. Many thanks as well to our collaborators across @espciparispsl.bsky.social , @cnrsbiologie.bsky.social, @sorbonne-universite.fr and beyond!
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faurelab.bsky.social @faurelab.bsky.social · 05/07/2025
Nicotine and alcohol seem very different, but they converge on the same circuit. Both activate NAc-projecting dopamine neurons and inhibit those projecting to the amygdala. We show that this shared loop shapes reward and emotion, helping explain their high co-use.
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faurelab.bsky.social @faurelab.bsky.social · 05/07/2025
A circuit-level explanation for nicotine’s dual impact: Nicotine activates VTA→NAc dopamine neurons (reward), but this comes at a cost: It triggers a GABAergic feedback loop that inhibits VTA→amygdala neurons (emotion). One drug, the dopaminergic circuits, 2 effects: reinforcement + negative affect.
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faurelab.bsky.social @faurelab.bsky.social · 05/07/2025
Nicotine doesn’t just “turn on” the brain’s reward circuits — it reshapes them. Our new paper in Nature Communications shows that activating reward-linked dopamine neurons also sets off a feedback loop that drives negative emotional states. www.nature.com/articles/s41...
nature.com
Nicotine engages a VTA-NAc feedback loop to inhibit amygdala-projecting dopamine neurons and induce anxiety-like behaviors - Nature Communications
Drugs of abuse exert both motivational and emotional effects. Here, the authors show that nicotine and ethanol activate a VTA–NAc loop that inhibits dopamine neurons projecting to the amygdala, thereb...
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faurelab.bsky.social @faurelab.bsky.social · 19/06/2025
Our work on the role of the interpeduncular nucleus in nicotine reward ( www.cell.com/neuron/abstr... ) is featured in a Neuron Preview ! Brandon J Henderson highlights how a new regulatory circuit controlling nicotine reinforcement has been uncovered. www.cell.com/neuron/abstr...
cell.com
Slowing the drive: A new regulatory break for nicotine reward-related behaviors
In this issue of Neuron, Jehl et al. developed a “suicide” antagonist to demonstrate that the interpeduncular nucleus acts as a regulatory controller of nicotine reward-related behavior through connec...
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faurelab.bsky.social @faurelab.bsky.social · 13/06/2025
Yesss! So happy to see this, totally deserved!
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Reposted by @faurelab.bsky.social
Luc Estebanez @lucestebanez.bsky.social · 05/06/2025
Our work on rubber hand embodiment in mice is out @plosbiology.org! We show that just like in humans, visuo-tactile pairing can lead mice to an embodiment-like behavior with respect to an artificial limb.
journals.plos.org
Embodiment of an artificial limb in mice
Body ownership disorders can be triggered by disease or body damage in humans. This study shows, using an automated, videography-based procedure, that mice also display quantifiable behavioral markers...
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Jérémie Naudé @jeremie-n.cpesr.fr · 28/05/2025
Nouvel article avec mes ami-es belges E. Chaves et A. de Kerchove où on décrit l'effet de l'activation de populations de neurones du striatum sur les stratégies de décision. On a essayé de sortir d'une définition "par l'expérimentateur" de la performance des souris. www.science.org/doi/10.1126/...
science.org
Direct and indirect striatal projecting neurons exert strategy-dependent effects on decision-making
In the dorsomedial striatum, d-SPNs increase risk seeking, while iSPNs amplify the value of large gains in decision making.
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Bassem Hassan @bassemh.bsky.social · 07/05/2025
Hot off the press: The excellent Maheva Andriatsilavo and colleagues show how a temporal sequence of stochastic molecular mechanisms allow the emergence of stereotyped individualised neuronal circuits. Just published in Nature Neuroscience: rdcu.be/ek010
rdcu.be
Sequential and independent probabilistic events regulate differential axon targeting during development in Drosophila melanogaster
Nature Neuroscience - The developmental origin of behavioral individuality is unclear. The authors show that a temporal sequence of genetically encoded stochastic mechanisms explains variation in...
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Louis-Eric Trudeau @louistrudeau.bsky.social · 24/04/2025
I have an opening in my lab for a postdoctoral fellow to work on projects that relate to the mechanisms of neurotransmitter release by dopamine neurons and/or on how inflammatory signals infuence the functionning of these neurons. Please share.
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faurelab.bsky.social @faurelab.bsky.social · 21/04/2025
free access here authors.elsevier.com/c/1kzRE3BtfH...
authors.elsevier.com
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faurelab.bsky.social @faurelab.bsky.social · 21/04/2025
Congrat J. Jehl, M. Ciscato, E. Vicq & @nicolasguyon.bsky.social . Thanks to our amazing team, and collaborators! @cnrsbiologie.bsky.social , @inserm.fr , @sorbonne-universite.fr , @espciparispsl.bsky.social , @institutpasteur.bsky.social, @frm-officiel.bsky.social
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faurelab.bsky.social @faurelab.bsky.social · 21/04/2025
This was made possible by a new chemogenetic method: a covalently tethered suicide antagonist for β4* nAChRs. Sustained, subtype-specific silencing in vivo, with single-site precision. A method developed by Alexandre Mourot in the lab @faurelab.bsky.social
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faurelab.bsky.social @faurelab.bsky.social · 21/04/2025
The interpeduncular nucleus (IPN) dampens nicotine reward via β4* nAChRs and IPN→LDTg projections. Blocking this pathway enhances VTA responses and CPP: A nicotine-specific brake embedded in the mesolimbic system. New paper from the lab out in @cp-neuron.bsky.social www.cell.com/neuron/abstr...
cell.com
The interpeduncular nucleus blunts the rewarding effect of nicotine
Nicotine activates the dopamine reward system to promote consumption and addiction, but the brain has a natural brake to counteract it. Jehl, Ciscato, Vicq, Guyon, et al. identified the interpeduncula...
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Nils Kolling @nilskolling.bsky.social · 08/04/2025
Registrations for the Symposium for the Biology of decision making (SBDM) in Lyon 2025 are finally open! sbdm2025.github.io Please spread the message!
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faurelab.bsky.social @faurelab.bsky.social · 11/02/2025
Social structures are dynamic: manipulating dopamine activity reshapes role distribution, confirming a feedback loop where social context modulates neural states, which in turn reinforce specialization.
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faurelab.bsky.social @faurelab.bsky.social · 11/02/2025
A reinforcement learning model reveals how competition for ressources drives behavioral specialization, with varying degrees of exploitation shaping social roles development and driving sex differences.
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faurelab.bsky.social @faurelab.bsky.social · 11/02/2025
Neural and computational analyses during the task reveal that dopaminergic activity in the ventral tegmental area (VTA) plays a key role in stabilizing social roles.
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faurelab.bsky.social @faurelab.bsky.social · 11/02/2025
Males exhibit clear divisions of labor, where worker-scrounger equilibria emerge from competitive dynamics. In contrast, females adopt more uniform & cooperative behaviors. These sex-specific differences arise only in group contexts—when tested alone, males and females show only subtle differences!
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faurelab.bsky.social @faurelab.bsky.social · 11/02/2025
How do animals self-organize into structured societies? Using behavioral tracking, neural recordings, and reinforcement learning models, we show that small groups of isogenic mice spontaneously develop specialized roles.
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faurelab.bsky.social @faurelab.bsky.social · 11/02/2025
New preprint from the lab and @clementsolie.bsky.social on social organization & neuromodulation! Read the full preprint here: www.biorxiv.org/content/10.1... @espciparispsl.bsky.social @cnrsbiologie.bsky.social
biorxiv.org
Dopaminergic mechanisms of dynamical social specialization in mouse microsocieties
Social organization and division of labor are fundamental to animal societies, but how do these structures emerge from individual interactions, and what role does neuromodulation play in shaping them?...
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Anastasia Christakou 💙 @christakou.bsky.social · 22/01/2025
This is one of my favourite papers for a while. Theoretically informed, technically accomplished, well-written and argued, articulates explanation 👏 By @jeremie-n.bsky.social and colleagues. I would love to teach it but it may be a lot... www.nature.com/articles/s41...
nature.com
Dopamine builds and reveals reward-associated latent behavioral attractors - Nature Communications
The reason why manipulating dopamine (DA) activity can affect both action latency, action direction, and movement vigor, but only in certain animal states and behavioral settings is not fully understo...
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faurelab.bsky.social @faurelab.bsky.social · 05/02/2025
And the News & Views www.nature.com/articles/s42...
nature.com
Memory with a little H2O2 help from astrocyte friends - Nature Metabolism
Rabah et al. elegantly show that, in Drosophila, astrocytes signal to neurons with hydrogen peroxide to encode memories. This redox-based communication is disrupted by amyloid-β, a mechanism that pote...
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faurelab.bsky.social @faurelab.bsky.social · 05/02/2025
Superb study from Thomas Preat's team here @espciparispsl.bsky.social @cnrsbiologie.bsky.social , showing that astrocytes use redox H₂O₂ signaling to support memory in Drosophila. Amyloid-β disrupts this process, linking it to cognitive deficits in Alzheimer’s. www.nature.com/articles/s42...
nature.com
Astrocyte-to-neuron H2O2 signalling supports long-term memory formation in Drosophila and is impaired in an Alzheimer’s disease model - Nature Metabolism
Rabah et al. discover an astrocyte-to-neuron hydrogen peroxide signalling cascade, which is crucial for long-term memory formation in Drosophila. This signalling is found to be inhibited by amyloid-β ...
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CNRS Biologie @cnrsbiologie.bsky.social · 22/01/2025
#RésultatScientifique🔎Comment la dopamine peut-elle orchestrer à la fois l’apprentissage et la motivation ? @jeremie-n.bsky.social propose une réponse à cette question dans @naturecomms.bsky.social ⤵️ 🤝 @cnrsoccitanieest.bsky.social @umontpellier.bsky.social @cnrsinformatics.bsky.social
buff.ly
De l’apprentissage à l’action : la dopamine révèle nos apprentissages cachés
La dopamine, une molécule clé dans le cerveau, est essentielle à l’
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Philippe Domenech @philippedomenech.bsky.social · 14/11/2024
🚨 !!! Postdoc Position Available !!! 🚨 Join our team at the Neuromodulation Institute (Hôpital St-Anne) in Paris, France. Work on cutting-edge research involving voltammetric recordings in human patients and machine learning. 🧠🟦 / 🧠🤖 / 🧠🩺 #AcademicSky #postdoc
A view of Saint-Anne hospital in Paris
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faurelab.bsky.social @faurelab.bsky.social · 14/11/2024
By combining detailed biophy models with reduced theoretical ones, we could visualize the latent attractor dynamics DA creates and predict their effects on behavior. This lets us connect complex neural dynamics to action, opening the way for experimental testing and validation.
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faurelab.bsky.social @faurelab.bsky.social · 14/11/2024
Our model suggests that DA’s role in goal seeking is context-dependent and dynamic, linking motivation to learning.
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faurelab.bsky.social @faurelab.bsky.social · 14/11/2024
Our key finding? DA is more than a "reward" signal ! It creates latent attractors in the brain that later pull animals toward goals - but not automatically: DA plasticity only forms latent attractors, while DA excitability reveals them, leading to strong convergence to reward locations.
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