The UK Government has formed a new National Cancer Board to drive delivery of its 2026 National Cancer Plan, a strategy blueprint aimed at transforming cancer care and outcomes in England by 2035.

Nature Reviews Drug Discovery - Two trials or not two trials? That should not be the question

In light of the US FDA announcement supporting the use of Bayesian methods in clinical trials, we present a nontechnical review of problems with Bayesian analyses and methods to address them. Our focu...

Nature asked eight leaders in higher education what they thought about the state of UK institutions. Here’s how they answered.

Scientists are probing whether language models trained on historical data can reproduce creative breakthroughs.

Dichotomisation of continuous outcomes into 'responder' and 'non-responder' categories remains widespread in clinical research, particularly where a threshold carries clinical meaning (e.g. blood

This comparative study of cancer clinical trial portfolios assesses differences between federal and industry sponsors in cancer clinical trial research.

The way we tell the difference

British Journal of Cancer - Oncology drug development in the UK: analysis of the past 25 years and focus on the 2026 reboot of the clinical trial regulatory framework

Once dubbed ‘the most dangerous man on Earth’, the world-renowned moral philosopher discusses accepting capitalism, the return of Trump and disappointment in his most famous work’s impact

These early results support a response-adapted organ-preservation approach, with LCCRT appearing more effective than SCRT at 12 months. Organ-preservation might also reduce treatment-related toxicity ...

Artificial intelligence (AI) is reshaping research and scientific publishing at an unprecedented pace, with extraordinary promise. We as editors embrace AI as a tool that can be helpful to researchers...

The Center for Open Science has announced that from November 16, 2026, no new projects can be created on the Open Science Framework. After F...

These functions have been deprecated in favor of pak, as that is what we now recommend for package installation. There are a few functions which have no pak equivalent, where you can instead call the ...

Objectives To assess the concordance of results between paired target trial emulations and their benchmarking randomised controlled trials and to explore determinants of emulation success. Design Sys...

Deal would create world’s fourth-largest drugmaker by market value

BBC Verify's analysis indicates “vegetation stress” in many areas, which may affect wildlife and farming.

The purposes of eligibility criteria for cancer clinical trials are to select the intended patient population and reduce potential risks to trial subjects.

Guidance for Industry, IRBs, and Clinical Investigators

The London School of Hygiene & Tropical Medicine (LSHTM) is one of the world’s leading public health universities. Our mission is to improve health and health equity in the UK and worldwide; working i...

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Simulation-guided clinical trial design can enable identification of the optimal design to bring safe and effective therapies to patients as efficiently as possible, and it is particularly useful when...

Determining the optimal dosage of oncology drugs is a critical component of drug development, as many anticancer agents are associated with high toxicity. With the emergence of targeted therapies and ...

Draft Guidance for Industry: Demonstrating Substantial Evidence of Effectiveness for Human Drug and Biological Products

Most original articles published in the medical literature report the results of multiple statistical tests. In a few simple cases, there is agreement on whether to adjust for the number of performed...

Joseph F. Fraumeni, Jr., M.D., biographical sketch

Imperial, the World Health Organization (WHO) Regional Office for Europe, and the European Association for the Study of the Liver (EASL) have launche...

Recent data show that glucagon-like peptide-1 receptor agonist (GLP-1RA) use is associated with decreased cancer incidence in diabetic and obese patients. However, there have been no studies exclusive...

Pathologist and athlete who was Australian of the year in 2024 underwent a bold experimental treatment after devastating brain cancer diagnosis

I was fortunate while on detail from Vanderbilt University to FDA CDER to be able to participate in numerous Bayesian committees and to provide input into the drafting of the new Bayesian guidance for...