iiinova — where your digital self keeps evolving

Erica Saint Clair, PhD @esaintclair.bsky.social · 13/01/2025

I just dug up some info on BioArctic's BrainTransporter tech - almost 10x increase in drug in the brain! That's quite the image 🧪

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Erica Saint Clair, PhD @esaintclair.bsky.social · 19/12/2024

Hoping to try out Boltz-1...we'll see how well it installs 🤞 #proteinfolding #boltz #alphafold

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Erica Saint Clair, PhD @esaintclair.bsky.social · 17/12/2024

Our #gingerbread is coming along. This year Jeff the #lochness monster is looking for a security job in the local town. Love that my little added a briefcase 😂

A gingerbread creation showing a bridge leading to what will be a town. A lockness monster weaves in and out of the water surrounding the town with a name tag of Jeff and a briefcase

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Erica Saint Clair, PhD @esaintclair.bsky.social · 13/12/2024

We've entered the time of year where I gain five pounds just by mixing up gingerbread...

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Erica Saint Clair, PhD @esaintclair.bsky.social · 12/12/2024

A nice handy slide from the FDA sessions at #ASH24 of CAR-T therapy approvals to date!

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Erica Saint Clair, PhD @esaintclair.bsky.social · 09/12/2024

Guys! #ASH24 had a #puppy pen!! Look at this little guy! Apparently 4 or 5 puppies have been adopted so far, which is nuts. I can't imagine going to a conference and coming home with a puppy (despite deep desire and begging from my littles)

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Erica Saint Clair, PhD @esaintclair.bsky.social · 09/12/2024

And 4/4. I am def not your person for questions - but anyone is always welcome to reach out to authors or presenters. I do that a lot for areas I research and always find people are more than happy to chat about their work. But of course, be kind to them :)

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Erica Saint Clair, PhD @esaintclair.bsky.social · 09/12/2024

Ignore my typos...its been a long day and I'm tired. continuing on 2/x

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Erica Saint Clair, PhD @esaintclair.bsky.social · 09/12/2024

Slide deck from the #Keto and #Car-T talk at ASH today - for those interested. Going to try and post in a reasonable order, but failry new to bluesky...a thread... 1/x @donadickinson.bsky.social @bigmoke.bsky.social @tmask.bsky.social

Slide - Keto diet enhances CART cell antitumor function via beta hydroxybutyrate

Shows patient with an IV drip bag full of CART product, and a tumor inside the cartoon body

Shows macro nutrient breakdown of various diets, and tumor burden based on diet post CART therapy

Shows keto enhanves CART19 proliferation via beta hydroxybutyrate

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Erica Saint Clair, PhD @esaintclair.bsky.social · 08/12/2024

#Rilzabrutinib Phase 3 LUNA 3 results in #thrombocytopenia at #ASH24 16/18 patients responded in two weeks 🧪

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Erica Saint Clair, PhD @esaintclair.bsky.social · 08/12/2024

Dr. Shan Liu just called out the Western diet as the "Fast Food" diet and she ain't wrong 😂 And look, the Western diet upped tumor volume... I have a good friend who came back from stage 4 lung cancer after a *massive* diet change, so I find this talk on #keto boosting #Car-T interesting #ASH24 🧪

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Erica Saint Clair, PhD @esaintclair.bsky.social · 08/12/2024

What am I missing? The #cemsidomide MonoDACTM degrader results showed a patient case study. It looks like it worked great during the first month, but after a few months disease came back with a bang...and close to 9 in 10 pts discont. (I recognize its a heavily pretreated pop. & oral) #ASH24 🧪

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Erica Saint Clair, PhD @esaintclair.bsky.social · 08/12/2024

Big congrats to Dr Rachel Rau looking at #blinatumomab in kids. Adding it into standard #chemo significantly cut relapses and increased disease free survival. She mentioned the data monitoring board suggested a stop to randomization for efficacy. #ASH24 #ASH2024 🧪

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Erica Saint Clair, PhD @esaintclair.bsky.social · 06/12/2024

Off to #ASH24!! Ready for some sun and lots of learning!

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Erica Saint Clair, PhD @esaintclair.bsky.social · 06/12/2024

The self-restraint it took not to eat all my end of the year thank yous to work colleagues... But seriously, #tonyschocoloney is my fave. And nothing beats the caramel sea salt.

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Erica Saint Clair, PhD @esaintclair.bsky.social · 06/12/2024

Hired out my first project on Fivver- turning my kids art into patches as a #stockingstuffer for my hubs. They need some work, and likely a different base material, but I am so excited!! #embroidery

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Erica Saint Clair, PhD @esaintclair.bsky.social · 03/12/2024

Pretty excited about my #hiking club holiday patches this year!! #takeahike #embroidery

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Erica Saint Clair, PhD @esaintclair.bsky.social · 03/12/2024

Has anyone else gotten completely addicted to #puzzmo? Found it during the #NYT tech worker strike and now I'm eyeing it as a stocking stuffer (for myself lol)

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Erica Saint Clair, PhD @esaintclair.bsky.social · 03/12/2024

I will always be so grateful for #AlphaFold collab. What an awesome tool! 🧪

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Erica Saint Clair, PhD @esaintclair.bsky.social · 14/05/2024

And if you're curious about what makes each color :)

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Erica Saint Clair, PhD @esaintclair.bsky.social · 14/05/2024

🧪Big fan of sun storms paired with clear Earth skies! I'd love to see your pics if you got to see the aurora in action!

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Erica Saint Clair, PhD @esaintclair.bsky.social · 09/04/2024

Spent 8 days in Texas. It was wild, hot, dry, and exhausting. Yesterday, despite massive cloud coverage we got to see a few glimpses of the #eclipse in action - it was the ultimate topping to an amazing trip!

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Erica Saint Clair, PhD @esaintclair.bsky.social · 07/03/2024

More than half of people getting plaque removed from their major arteries also had microplastic in their plaque. And those with microplastics were 4.5 times more likely to die for any reason...🤯 Ill just be over here buying new Tupperware...the glass kind...🧪 www.nejm.org/doi/full/10....

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Erica Saint Clair, PhD @esaintclair.bsky.social · 07/03/2024

It's amazing to see the rapid pace of development in obesity. Just think of the health benefits all around And it looks like oral options are slowly making their way through trials. (yes, I know Novo has oral sema, but it has to make *gobs* of it for each pill so its not really all that viable) 🧪

Results of Novo Nordisk's new Amycretin oral anti-obesity drug in Phase 1. A graph shows patients on drug lost 13% bodyweight over 12 weeks, while those on placebo lost 1% (but hovered around the 0%)

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Erica Saint Clair, PhD @esaintclair.bsky.social · 26/02/2024

Wow, 20% of over 65 year old AML patients on Iomab-B survived a year. 10% made it to TWO years. 👀👀 No one getting today's best available AML care made it to either mark... Oh an 💯% of Iomab-B patients got bone marrow transplant! 🧪 ir.actiniumpharma.com/press-releas...

Table of overall survival in AML patients over 65 with IomabB treatment versus conventional care. 20.1% on IomabB survived 1 year, 11.5% survived two years. 0% survived 1 or 2 years on conventional care

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Erica Saint Clair, PhD @esaintclair.bsky.social · 11/02/2024

If you're looking for a last minute fun, and bright, little card project to do with your kids, check out my paper circuit templates! rosieresearch.com/diy-3d-cards...

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Erica Saint Clair, PhD @esaintclair.bsky.social · 08/02/2024

Madrigal's reported NASH data assumes anyone who didn't get a biopsy failed (fair in a clinical trial). But analysis of just the patients who got biopsies shows even better results for the drug. So the good news got better for a set of patients with no current therapy! 🧪 www.nejm.org/doi/full/10....

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Erica Saint Clair, PhD @esaintclair.bsky.social · 06/02/2024

I'm interested in Amgen's new weight loss drug - the idea to block GIP with an antibody and boost GLP with a peptide (that's connected!) is really cool. But on the other hand, the adverse effects are definitely....meh.... 🧪 Phase 1 results paper: pubmed.ncbi.nlm.nih.gov/38316982/

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Erica Saint Clair, PhD @esaintclair.bsky.social · 25/01/2024

I think one of the biggest 20/20 hindsight "duh" moments with the weight loss drugs will be the lack of a push towards also moving more. I rarely see chatter about exercise - just, take this shot and shed the weight. Hope that changes soon www.ahajournals.org/doi/suppl/10... 🧪

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Erica Saint Clair, PhD @esaintclair.bsky.social · 25/01/2024

I just really don't understand this stuff. Like, if you don't have the data point, retake the data point. Why reuse an image - if you *know* there is a null you should be able to *show* there is a null... It's really beyond me that scientists do this, or photoshop things to make them more "clear"

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Erica Saint Clair, PhD @esaintclair.bsky.social · 16/01/2024

I'm feeling exceedingly good about Jack Reacher and his special investigators unit 😂

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Erica Saint Clair, PhD @esaintclair.bsky.social · 10/01/2024

TIL Kristian Blummenfelt not only won the first Ironman he ever competed in, he set the world record. That's insane. I also learned we don't look at muscle oxygenation enough and could all maybe be super human if we did? Probably not. I like cake on the couch too much. I suspect I'm not alone...

Kristian Blummenfelt crosses the finish line at the 2021 Cozumel Ironman. He set the world record of 7 hours 12 minutes

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Erica Saint Clair, PhD @esaintclair.bsky.social · 09/01/2024

I was so focused on AD the PD part of the table flew right out my brain - flu led to 2-3ish increased odds of PD! Yikes www.cell.com/neuron/fullt...

A table pulled from "Virus exposure and neurodegenerative disease risk across national biobanks" showing the risk of developing PD after specified viral infections.

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Erica Saint Clair, PhD @esaintclair.bsky.social · 03/01/2024

Just read the NIA's paper on viral infections an neurodegenerative diseases. Even just the flu boosts your chances of Alzheimer's by ~3x. Makes me wonder about COVID... Full data here: www.cell.com/neuron/fullt...

A table showing results from a data analysis on the FinnGen and UK biobank showing a relationship between Alzheimers disease and viral encephalitis, viral and other specified intestinal infections, influenza and pneumonia, and meningitis. This is a screen shot from Levine et al, Neuron 2023

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Erica Saint Clair, PhD @esaintclair.bsky.social · 14/12/2023

Really hoping next year's #ASH2023 lines up with the San Diego #SantaRun once again. Running with 6,000 santas was a ton of fun!

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Erica Saint Clair, PhD @esaintclair.bsky.social · 13/12/2023

Excited about the work coming out of Fabian Mullers group on CAR-T in systemic lupus. Updated patient results at this years ASH were good news for patients with severe lupus and other autoimmune diseases

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