Sign in

Dr. Märt-Erik Mäeots

@erikmaeots.bsky.social
731 followers 404 following 15 posts

Postdoc designing proteins and predicting protein-protein and protein-nucleic acid complexes at University of Zürich. Previously: Time-resolved cryo-EM methods and AI models for cryo-EM optimization at The Francis Crick Institute.

PostsRepliesMedia
Dr. Märt-Erik Mäeots @erikmaeots.bsky.social · 22h
Caveat being that data was pristine and I was using alignments from EMPIAR
110
Dr. Märt-Erik Mäeots @erikmaeots.bsky.social · 23h
I was testing it with around 2.5k particles and got a surprisingly good proxy for QScore. I was able to detect incorrectly assigned rotamers, even without access to a map, around 60% of the time (WIP). I have not tested with many particles yet.
120
Reposted by Dr. Märt-Erik Mäeots
Kelvin Lau @klausenhauser on 🙅‍♂️🐘🪡 @klausenhauser.bsky.social · 10/10/2026
Anyone else seen this? CryoEM models without any volume reconstruction. Straight from the micrographs, inferred structures restrained by the actual particle data. So sequence + limited particles = structure?! Bypassing all that time making a map just to still model after arxiv.org/html/2610.01...
2307
Dr. Märt-Erik Mäeots @erikmaeots.bsky.social · 23h
Confidence metrics are a major focus for us, we have a method to obtain QScore-like metrics for Fold'EM, since we have particles and alignments. For the full manuscript this will be included.
150
Dr. Märt-Erik Mäeots @erikmaeots.bsky.social · 21/09/2026
Great pleasure to have worked on this! Design peptides, miniproteins, megaproteins, nanobodies, ScFvs, anything you want all under one roof of BindCraft2. And it's easier, faster, and better than ever! Includes multitargeting against multiple different proteins as well.
1112
Dr. Märt-Erik Mäeots @erikmaeots.bsky.social · 14/07/2026
Chromatin is so beautiful 😍
010
Reposted by Dr. Märt-Erik Mäeots
Reese Richardson @reeserichardson.bsky.social · 28/05/2026
TL;DR: We've identified more than 100 cases of apparent manipulation in Thermo Fisher Scientific's antibody verification data. @sholtodavid.bsky.social @johanduchene.bsky.social reeserichardson.blog/2026/05/28/h...
reeserichardson.blog
How much of Thermo Fisher’s antibody data has been manipulated?
We’ve documented more than 100 instances of apparent data manipulation in Thermo’s catalog
23591312
Reposted by Dr. Märt-Erik Mäeots
Nature Structural & Molecular Biology @natsmb.nature.com · 23/01/2026
New online: When cryo-EM modeling meets structure prediction
dlvr.it
When cryo-EM modeling meets structure prediction
Nature Structural & Molecular Biology, Published online: 23 January 2026; doi:10.1038/s41594-026-01744-4Accurately interpreting density maps into atomic models is a central yet challenging goal of cryo-EM. Two studies now reveal distinct ways in which protein structure prediction can be incorporated into cryo-EM model building to enable more accurate and robust automated construction of protein atomic models from density maps.
0106
Reposted by Dr. Märt-Erik Mäeots
Martin Pacesa @martinpacesa.bsky.social · 27/08/2025
Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian, @sokrypton.org, Bruno and many other amazing lab members and collaborators. www.nature.com/articles/s41...
14305109
Reposted by Dr. Märt-Erik Mäeots
Seemay Chou @seemaychou.bsky.social · 12/08/2025
What’s the next PDB? Maybe it’s …the PDB. We just launched @diffuseproject.bsky.social a structural biology initiative exploring protein motion & rethinking how we generate and use experimental data. Quick 🧵👇 www.diffuse.science
diffuse.science
The Diffuse Project
The Diffuse Project
45315
Dr. Märt-Erik Mäeots @erikmaeots.bsky.social · 31/07/2025
A hair dryer is probably the cheapest option for drying tools.
010
Dr. Märt-Erik Mäeots @erikmaeots.bsky.social · 23/04/2025
We combine all our tech into a data-driven workflow to optimize bespoke sample prep conditions per sample, at minimal additional effort for the user. Our next goal will be to make our system more widely available to everyone. #cryoEM
010
Dr. Märt-Erik Mäeots @erikmaeots.bsky.social · 23/04/2025
We show a quantitative approach to cryo-EM sample preparation using high-speed cameras. We quantify ice thickness on *full* atlases in the TEM. We then use ‘manual gradient descent’ to improve our sample preparation method and try all sorts of things. In total, we made 2000 grids for this project!
200
Dr. Märt-Erik Mäeots @erikmaeots.bsky.social · 23/04/2025
Time-resolved cryo-EM! We captured the earliest intermediates of homologous recombination in RecA with known lifetimes in milliseconds. We show that trEM can capture an incredible number of transient states, far beyond what we had hoped starting this project. www.biorxiv.org/content/10.1...
151
Dr. Märt-Erik Mäeots @erikmaeots.bsky.social · 10/04/2025
Very curious as mostly you are quoting the scientists themselves. I can't imagine the hubris to claim that these people's lived experience does not reflect reality?
080
Reposted by Dr. Märt-Erik Mäeots
ChristopherE @christopher664023.bsky.social · 08/11/2024
In 1890, the X and Y chromosomes were discovered. It was found that the men who were tested had 46 chromosomes, including an X and a Y, while women who were tested also had 46 chromosomes, including 2 X chromosomes. So obviously the conclusion was that the Y chromosome defined masculinity.
44770862521
Dr. Märt-Erik Mäeots @erikmaeots.bsky.social · 19/11/2024
Very cool! I enjoyed the read.
010
Dr. Märt-Erik Mäeots @erikmaeots.bsky.social · 18/11/2024
I imagine it shifting the boundary between industry projects and academic ones. Academics will just move onto the next problem which we can't brute force. Hopefully this future will accelerate medical research.
000
Dr. Märt-Erik Mäeots @erikmaeots.bsky.social · 16/11/2024
Why is Trae getting worse every year?
000
Dr. Märt-Erik Mäeots @erikmaeots.bsky.social · 14/11/2024
It also helps that twitter is objectively bad now with bots and spam taking up 90% of the platform. I've finally had enough.
000
Dr. Märt-Erik Mäeots @erikmaeots.bsky.social · 14/11/2024
It also helps that twitter is objectively bad now with bots and spam taking up 90% of the platform. I've finally had enough.
000
Dr. Märt-Erik Mäeots @erikmaeots.bsky.social · 23/01/2024
Sounds terrifying to put a grid full of magnetic beads into an em. :O
010