Metastasis is a leading cause of mortality in breast cancer patients, yet the signaling promoting metastatic dissemination is not completely understood. Prior literature implicates neuronal innervatio...

The balance of protein phosphorylation is often disrupted in cancer, with hyperactivity of kinases and inactivation of phosphatases driving cell proliferation and survival pathways. PTPRH, a protein t...

The E2F transcription factors are well-established cell cycle regulators, but their roles in coordinating proliferation and differentiation remain poorly understood. Here, we investigated the function...

Metastasis is the leading cause of death in breast cancer, yet the mechanisms controlling organotropism are not well defined. Coagulation has emerged as a biologically relevant contributor to metastat...

Our previous work has uncovered key mechanisms linking systemic changes to tumor initiation, single cell signatures of models of breast normal and cancer development and identified epigenetic and...