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Emily Addington

@emilyaddington.bsky.social
277 followers 380 following 3 posts

Postdoc in the Roe Lab, Glasgow, working on the genotoxin colibactin. Interested in pathogenic E. coli, the gut microbiome, and CRC. She/Her. 🇧🇲 🏴󠁧󠁢󠁳󠁣󠁴󠁿 🏳️‍🌈

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Reposted by Emily Addington
Giusy Mariano @giusym1990.bsky.social · 04/04/2025
For those of you who approached me at @microbiologysociety.org #Microbio25 (and anyone else interested!!), this is your last chance to apply for our PDRA position. Come join us in Glasgow!
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Reposted by Emily Addington
Conor Feehily @sligomicrobe.bsky.social · 02/04/2025
If you're still at #MircoBio25, head down to poster 89 and catch up with all the work that @phoebecrossley.bsky.social is up to as part of her PhD in my lab #microsky #vaginalmicrobiome
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Reposted by Emily Addington
Professor Andrew J Roe @drandyjroe.bsky.social · 01/04/2025
New paper from the group - here we show that aurodox prevents shiga toxin mediated damage in a murine model. Interesting changes to the microbiota too. Amazing work by @rebeccamchugh.bsky.social and the group. Paper here- rdcu.be/efW0K
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Reposted by Emily Addington
Xavier Charpentier @labxc.bsky.social · 13/02/2025
The most worrisome is that this strain is a well know producer of the colibactin genotoxin, which may be associated with colorectal cancer bsky.app/profile/them...
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Reposted by Emily Addington
Suzie Humphrey @suzieh.bsky.social · 08/02/2025
🚨 #PhD opportunity! 🚨 Come and work with @evaheinz7.bsky.social and me at the University of Strathclyde (Glasgow) on an exciting project investigating the roles that #bacteriophages play in the evolution and virulence of #enterococci. 🧫🧬 Details here: www.strath.ac.uk/studywithus/...
strath.ac.uk
Determining the influence of bacteriophages in enterococcal infections | University of Strathclyde
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Reposted by Emily Addington
Giusy Mariano @giusym1990.bsky.social · 24/01/2025
🚨We are hiring! A MRC-funded PDRA position to study novel anti-phage systems & their evolutionary dynamics in P. aeruginosa, in collaboration with @friendlymicrobe. If you are passionate about phage-bacteria interactions & evolution, apply now ! tinyurl.com/bddz4z44
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Reposted by Emily Addington
Liam Rooney @liam-rooney.bsky.social · 10/01/2025
New Scientist (@newscientist.bsky.social) wrote a feature on our work! 🧪✨🔬 We made the first fully 3D printed microscope, with potential for rapid customisation and low-cost manufacturing. newscientist.com/article/2462618-worlds-first-fully-3d-printed-microscope-made-in-under-3-hours/
newscientist.com
World’s first fully 3D-printed microscope made in under 3 hours
The microscope cost less than £50 to build using an open-source design and a common 3D printer
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Emily Addington @emilyaddington.bsky.social · 12/12/2024
go.bsky.app/CJyjtir A starter pack of researchers in bacteriology at the University of Glasgow. Will be updated as members of the department join bsky. 🔬🧬🧫🥼
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Reposted by Emily Addington
Professor Andrew J Roe @drandyjroe.bsky.social · 29/11/2024
New paper from the group. Very proud to share our recent work for the first time here on Bluesky- give me 50 likes and it’s a permanent move!🤣. doi.org/10.1098/rsob...
Cartoon showing how aurodox can inhibit multiple gram negative pathogens. Image by Iris Floria
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Reposted by Emily Addington
Amir Mitchell @amitchell.bsky.social · 02/12/2024
Our second paper on the bacterial toxin colibactin is now out on mBio, this time we critically evaluated the claim that colibactin toxicity necessitates cell-cell contact 🧪🦠🧵(1/9) journals.asm.org/doi/10.1128/...
Cartoon of two bacteria on a petri dish
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Reposted by Emily Addington
Joram Mooiweer @jorammooiweer.bsky.social · 07/11/2024
Colibactin-producing E. coli 🦠 uses adhesin proteins to bind to colon cells, driving DNA damage 🧬 and tumor growth in #CRC. Blocking this binding with targeted inhibitors could open paths to anti-cancer therapies! 🌟! #Microbiome #ColorectalCancer #GutHealth #ImmunoSky www.nature.com/articles/s41...
nature.com
Colibactin-driven colon cancer requires adhesin-mediated epithelial binding - Nature
The oncogenic potential of pks+ Escherichia coli depends critically on bacterial adhesion to host epithelial cells mediated by the type 1 pilus adhesin FimH and the F9 pilus adhesin FmlH.
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Reposted by Emily Addington
Tommi Mäklin @themaklin.bsky.social · 05/12/2024
New paper: We show that population exposure to colibactin producing E. coli lineages ST95 and ST73 largely explains global variation in colorectal cancer incidence. Same STs are also major causes of UTIs and may be similarly involved in urinary tract cancers. www.sciencedirect.com/science/arti...
sciencedirect.com
Geographical variation in the incidence of colorectal cancer and urinary tract cancer is associated with population exposure to colibactin-producing Escherichia coli
Biomedical research has implicated the bacterial metabolite colibactin as a causal risk factor for several cancer types, in particular, colorectal can…
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Emily Addington @emilyaddington.bsky.social · 06/02/2024
I wrote a short blog post for the Microbiology Society regarding our recent colibactin regulation review. Available here. @sofiasandalli.bsky.social @drandyjroe.bsky.social
microbiologysociety.org
Regulation of a carcinogenic genotoxin
<span style="font-family:&quot;Calibri&quot;,sans-serif; font-size:11.0pt; mso-ansi-language:EN-GB; mso-ascii-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-language:AR-SA; mso-bidi-them...
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Reposted by Emily Addington
James Connolly @ruamicro.bsky.social · 23/12/2023
Really pleased to share Curtis Cottam’s first paper from his PhD, where he discovered a new Arabinose transporter in pathogenic E.coli and investigated the impact of Arabinose utilisation on virulence gene regulation. www.biorxiv.org/content/10.1...
biorxiv.org
Metabolism of ʟ -arabinose converges with virulence regulation to promote enteric pathogen fitness
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
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Emily Addington @emilyaddington.bsky.social · 05/02/2024
@sofiasandalli.bsky.social @drandyjroe.bsky.social and I wrote a little review about colibactin, with a brilliant graphical abstract by Iris Floria. You can read it here: go.shr.lc/42t0SCb
go.shr.lc
Current understandings of colibactin regulation
The biosynthetic machinery for the production of colibactin is encoded by 19 genes (clbA – S) within the pks pathogenicity island harboured by many E. coli of the B2-phylogroup. Colibactin is a pote...
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Reposted by Emily Addington
Paul Hoskisson 🧫 🦠🐸 @paulhoskisson.bsky.social · 28/11/2023
BBSRC NorthWest Bio Fully Funded Doctoral Training Programme #Studentship with me & @lore-fermar.bsky.social on understanding how antibiotic producing #Streptomyces bacteria adapt to their environment & how reproducible mutations are-Pls share-Details here www.gla.ac.uk/postgraduate...
gla.ac.uk
University of Glasgow - Postgraduate study - Centres for Doctoral Training - NorthWest Bio - Our Pr...
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