MALT1 inhibitor MI-2 induces ferroptosis by direct targeting of GPX4

Nature Reviews Molecular Cell Biology, Published online: 09 April 2025; doi:10.1038/s41580-025-00843-2Ferroptosis is a non-apoptotic type of cell death that is induced by uncontrolled iron-dependent phospholipid peroxidation and has important roles in disease. This Expert Recommendation article summarizes ferroptosis regulation and mechanisms and provides recommendations to increase the reproducibility and robustness of ferroptosis research.

Nature Reviews Molecular Cell Biology, Published online: 09 April 2025; doi:10.1038/s41580-025-00843-2Ferroptosis is a non-apoptotic type of cell death that is induced by uncontrolled iron-dependent phospholipid peroxidation and has important roles in disease. This Expert Recommendation article summarizes ferroptosis regulation and mechanisms and provides recommendations to increase the reproducibility and robustness of ferroptosis research.

Nature Reviews Molecular Cell Biology - Ferroptosis is a non-apoptotic type of cell death that is induced by uncontrolled iron-dependent phospholipid peroxidation and has important roles in...

Ito et al. highlight peroxiredoxin 6 (PRDX6) as a critical regulator of ferroptosis. As a selenium-acceptor protein, PRDX6 aids in intracellular selenium utilization for efficient selenoprotein biosyn...

Ito et al. highlight peroxiredoxin 6 (PRDX6) as a critical regulator of ferroptosis. As a selenium-acceptor protein, PRDX6 aids in intracellular selenium utilization for efficient selenoprotein biosyn...