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Exciting Instruments @ei-science.bsky.social · 15/09/2026

Boston researchers: Jake Isaacs, Mahmoud Abdelhamid and Robert Bell are available for meetings from 28 September–6 October. Have a system you’d like to discuss? Tell us what you’re working on and let’s arrange a chat: excitinginstruments.com/contact-us/

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Exciting Instruments @ei-science.bsky.social · 15/09/2026

Your molecules are doing something exciting, let's find out what! We’re visiting labs and conferences across Europe and Boston over the next few weeks. Come meet us 👇

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Exciting Instruments @ei-science.bsky.social · 10/08/2026

👀 Strong binding, but no degradation? Join Dr Stefan Mueller on 20 Aug to learn how FCCS on the EI-FLEX Pro HT reveals #ternarycomplex formation and #cooperativity - key insights for #PROTACs and #molecularglues. Register: us06web.zoom.us/meeting/regi... #drugdiscovery #targetedproteindegradation

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Exciting Instruments @ei-science.bsky.social · 06/08/2026

"PhotonFit has completely removed that friction." - Dr Janice Pata, Wadsworth Centre, NYSDOH. PhotonFit brings smFRET, FCS and FCCS into one intuitive workspace, so researchers can focus on biology instead of debugging code. Watch: www.youtube.com/watch?v=_8S7... #smFRET #FCS

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Exciting Instruments @ei-science.bsky.social · 04/08/2026

Join Dr Stefan Mueller on 20 Aug to see how FCCS on the EI-FLEX Pro HT directly quantifies ternary complex formation, cooperativity and stability for next-generation therapeutics. Register: us06web.zoom.us/meeting/regi... #ternarycomplex #fccs #proteininteractions #drugdiscovery

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Exciting Instruments @ei-science.bsky.social · 13/07/2026

📢 Today's the day! Join Tim Craggs and Prof. Taekjip Ha for this afternoon's Exciting Seminar celebrating 30 years of smFRET. Hear from the pioneer behind the first smFRET measurement and discover what's next. Register: us06web.zoom.us/meeting/regi... #biophysics #singlemoleculeFRET #virtualevent

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Exciting Instruments @ei-science.bsky.social · 01/07/2026

📢 Join us on 13 July for a virtual seminar on Conformational control: From single-molecule FRET to novel biotechnologies with our CEO Tim and Prof. Taekjip Ha. 11:00am EDT | 8:00am PDT | 4:00pm BST | 5:00pm CEST Register: us06web.zoom.us/meeting/regi... #smFRET #biophysics #singlemolecule

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Exciting Instruments @ei-science.bsky.social · 18/06/2026

Some molecules don’t like to sit still. That’s why Karim & Roman are heading to #ESAB2026 in #Montpellier! Visit us at booth 5 to explore #smFRET, #FCS & #FCCS, uncover molecular dynamics and interactions in solution, and see how EI-FLEX brings #single-molecule fluorescence into everyday workflows.

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Exciting Instruments @ei-science.bsky.social · 16/06/2026

🎉 #smFRET has been transforming how we study molecular interactions and dynamics for 30 years! Join us on 13th July as we celebrate past discoveries, current capabilities, and future frontiers. Featuring Prof. Taekjip Ha, who made the first-ever smFRET measurement. Register: buff.ly/riRgb6b

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Exciting Instruments @ei-science.bsky.social · 08/06/2026

👋 Hands up who's at #MachinesonGenes this week! Find Roman to learn how our easy-to-use tools allow you to assess the conformational dynamics and interactions of individual molecular machines. In solution, on the benchtop. Don't miss his talk on Tuesday morning (10:20 am). #smFRET #FCS

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Exciting Instruments @ei-science.bsky.social · 29/05/2026

Running smFRET experiments, but unsure how to label your samples or choose the right dyes? Our technical note covers dye selection, site-specific labelling, and key design considerations to help you get reliable data. 📖 excitinginstruments.com/resource-lib... #smFRET #biophysics #biochemistry #howto

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Exciting Instruments @ei-science.bsky.social · 26/05/2026

👀 Does the answer to your scientific question depend on understanding how molecules truly interact in solution? 🙌 FCS and FCCS make these measurements possible, at single-molecule sensitivity and without surface immobilisation. 📘 Learn more in our new handbook > buff.ly/CH1uUcm

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Exciting Instruments @ei-science.bsky.social · 21/05/2026

🙌 Yesterday at #smbio26 was a shining example of cutting-edge single-molecule science in the UK. The team is on hand again today to discuss how our technology can help you see all the Exciting things your molecules are doing. Want a demo of our system at our nearby HQ? Just let the team know.

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Exciting Instruments @ei-science.bsky.social · 20/05/2026

👀 Crystal structures don’t always reveal the full conformational landscape of proteins. Using smFRET + FCS on the EI-FLEX, Howard et al. uncovered two previously unknown salt-dependent conformational states in the bacterial helicase Rep. Read more: buff.ly/smLjyaG #smFRET #FCS #biochemistry

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Exciting Instruments @ei-science.bsky.social · 18/05/2026

Who's heading to #smbio26 this week? Catch up with @timcraggs.bsky.social and @romanrenger.bsky.social to discover next-generation single-molecule fluorescence technologies that are helping researchers reveal biomolecular interactions and dynamics with exceptional sensitivity and throughput.

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Exciting Instruments @ei-science.bsky.social · 14/05/2026

🤔 Is the ‘average’ molecule a liability in modern drug discovery? Bulk assays hide the transient states that decide whether biologics & TPDs succeed. Discover how smFRET, FCS & FCCS can accelerate drug discovery > buff.ly/fEfiuJM

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Exciting Instruments @ei-science.bsky.social · 13/05/2026

🔎 How do antiviral therapeutics work at the molecular level Using smFRET + FCS, Groves et al. investigated how remdesivir and suramin inhibit SARS-CoV-2 RdRp, revealing distinct mechanisms of action beyond gel-based assays. 👀 excitinginstruments.com/resource-lib...

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Exciting Instruments @ei-science.bsky.social · 06/05/2026

🇺🇸 Heading to the Industrial Biostructures America #ProterosIBAConference next week? Visit Jake at our booth for an intro to the EI-FLEX Pro, enabling biopharma labs to distinguish individual conformers in solution and quantify biomolecular heterogeneity with ease. #drugdiscovery #biopharma

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Exciting Instruments @ei-science.bsky.social · 05/05/2026

🤔 Still wondering how smFRET works in practice - and how it complements your current techniques? Our handbook shows when and why to use it alongside existing methods to add dynamic, single-molecule insight. Download: buff.ly/CxuqL1A #smFRET #biophysics #biochemistry

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Exciting Instruments @ei-science.bsky.social · 30/04/2026

👋 Run a core facility with cryo-EM or X-ray crystallography? Add smFRET/FCS to reveal dynamics, heterogeneity & interactions in solution - helping your users link structure to function with the EI-FLEX system. excitinginstruments.com/ei-flex/?utm... #biophysics #biochemistry #corefacility

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Exciting Instruments @ei-science.bsky.social · 28/04/2026

Structures show what #proteins look like - but not how they move. Learn how #smFRET adds dynamics to X-ray, Cryo-EM & AlphaFold to reveal allostery, flexibility & cryptic sites. 👀 buff.ly/c9Bijmx

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Exciting Instruments @ei-science.bsky.social · 21/04/2026

🔬 Studying #protein-DNAinteractions and wondering how freely-diffusing #single-molecule techniques can support your research? Here are a couple of the most commonly asked questions we hear from scientists in this space. Find more on our protein-DNA application page > buff.ly/uOHzEy5

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Exciting Instruments @ei-science.bsky.social · 17/04/2026

Find Tim and Charlotte at today's #LondonPolymerGroup meeting (at @imperialcollegeldn.bsky.social) to learn how single-molecule data can complement your existing workflows to reveal polydispersity and #polymer conformational dynamics, and confirm nanoparticle cargo loading or leakage in real-time.

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Exciting Instruments @ei-science.bsky.social · 10/04/2026

🤔 How do #proteins reshape RNA dynamics? Static structures tell only half the story. Using smFRET on the EI-FLEX, the @chillzaa.bsky.social lab at @yorkuniversity.bsky.social mapped viral protein–dependent RNA pseudoknot formation - revealing it as a binary, protein-triggered event > buff.ly/IVQYK72

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Exciting Instruments @ei-science.bsky.social · 08/04/2026

👀 Your #molecules are doing something exciting! But what, exactly? Discover - when and why - #smFRET is the method of choice to use alongside your current techniques, adding a layer of dynamic data that can quantify #biomolecularconformations and complex formation. Learn more > buff.ly/arAGYZ4

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Exciting Instruments @ei-science.bsky.social · 01/04/2026

🙌 Congratulations to Chadda et al. on their new paper! #smFRET on the EI-FLEX provided a highly complementary technique alongside SEC, mass spectrometry, mass photometry & bulk FRET to elucidate the pathway that forms mature intasomes from viral #DNA & retrovirus integrase dimers.👀 > buff.ly/mkBUmjc

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Exciting Instruments @ei-science.bsky.social · 23/03/2026

Download our latest app note (produced in collaboration with the Coleman Lab at Lawrence Livermore National Laboratory) to discover how #FCS can be performed to assess #antibody-antigen binding affinities and generate Kd values for candidate molecules > excitinginstruments.com/resource-lib...

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Exciting Instruments @ei-science.bsky.social · 16/03/2026

👀 In our new application note, we demonstrate how fluorescence cross-correlation spectroscopy (FCCS) can be performed on the EI-FLEX system to characterise the formation of a ternary complex > excitinginstruments.com/resource-lib... #ternarycomplex #fccs #PROTACs #molecularglues

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Exciting Instruments @ei-science.bsky.social · 10/03/2026

Who's heading to the #ClimbTour #Sheffield edition tomorrow? Our very own @timcraggs.bsky.social will be joining a great lineup of founders, investors, and ecosystem leaders, coming together for an afternoon of insights and networking. Hope to see you there 🙌 #entrepreneurs #innovation #climbuk

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Exciting Instruments @ei-science.bsky.social · 04/03/2026

Check out our Novalix conference poster below, with a focus on true #ternarycomplex formation and cooperativity, and how the EI-FLEX Pro supports dynamic #proteincharacterisation in #induced-proximity #drugdiscovery. Email info@excitinginstruments.com to discuss the poster in more detail.

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Exciting Instruments @ei-science.bsky.social · 02/03/2026

🔍 Want to know whether your biomolecules form static, heterogeneous populations or are dynamically interconverting? Our latest appnote highlights how the EI-FLEX system can recover rates of molecular #conformationaldynamics, using #DNA hairpins as a well-characterised test system > buff.ly/zRH2KmM

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Exciting Instruments @ei-science.bsky.social · 25/02/2026

Want to add easy access to #smFRET, #FCS and #FCCS to your core facility? Our new tools for single-molecule measurements offer: 💪 Reliable performance ⚡ Intuitive workflows 🦶 Small footprint, big impact Learn more and get in touch > buff.ly/q8KQw0i #corefacilities #biophysics #singlemolecule

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Exciting Instruments @ei-science.bsky.social · 24/02/2026

👀 At #BPS but haven’t stopped by booth 401 yet? Meet the team to discover how you can unlock the ultimate #single-molecule resolution at your benchtop, generating high-impact insights into #biomolecular interactions and dynamics. See you there! @biophysicalsoc.bsky.social #biophysics #lifescience

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Exciting Instruments @ei-science.bsky.social · 19/02/2026

At the final day of the @novalix.bsky.social conference? If you haven't had chance to meet with Audrey and Jake yet, there's still time to discuss how confocal fluorescence spectroscopy can accelerate your induced-proximity drug screening ⚡ #ternarycomplex #molecularglues #PROTACs #novalix

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Exciting Instruments @ei-science.bsky.social · 17/02/2026

🚀 Big news from @timcraggs.bsky.social x #BPS2026: meet the new EI-FLEX Pro! Automated alignment + focus, real-time analysis with publication-ready plots, modular upgrade to 96/384 wells, no darkroom or optical table, compact benchtop. Meet us at booth 401 or get in touch for a demo! #singlemolecule

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Exciting Instruments @ei-science.bsky.social · 11/02/2026

What better way to start your day than by exploring the key components of a confocal FRET experiment that ensure single-molecule sensitivity and accurate determination of FRET efficiencies? > buff.ly/NMausGH #singlemolecule #FRET #molecularbiophyics #biochemistry #molecules

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Exciting Instruments @ei-science.bsky.social · 05/02/2026

🇺🇸 Heading to #Novalix? Learn how confocal fluorescence spectroscopy accelerates induced-proximity drug screening. Meet our US team, Audrey & Jake, to discuss #biophysicalscreening, #molecularglues and #PROTACs, #single-molecule #proteindynamics, and more. Look out for their booth and poster!

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Exciting Instruments @ei-science.bsky.social · 26/01/2026

👀 Looking for #mechanisticinsight beyond traditional biochemistry? Our EI-FLEX system reveals in-solution dynamics, kinetics & rare events with intuitive software that delivers publication-ready plots and clear interpretation in minutes. No biophysics expertise needed 💪> buff.ly/FTlfZgO

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Exciting Instruments @ei-science.bsky.social · 21/01/2026

Want to add fast, solution-based #single-molecule dynamics to your workflow? Our new, practical handbook shows how confocal #smFRET reveals conformational change, heterogeneity & nanoscale distances, with clear, step-by-step guidance from basics to advanced analysis > buff.ly/xHefIrP

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Exciting Instruments @ei-science.bsky.social · 19/01/2026

📢 Structural biochemists: do you have beautiful, atomic-resolution static structures, but feel like a piece of the puzzle is missing? Add single-molecule dynamics with smFRET to reveal hidden conformational changes 👉 excitinginstruments.com/resource-lib... #structuralbiology #proteindynamics

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Exciting Instruments @ei-science.bsky.social · 14/01/2026

🇺🇸 Are you in #SanFrancisco this week for #JPM26, or local to the area, and curious to learn more about the power of high-throughput single-molecule characterisation? Drop @timcraggs.bsky.social or @robertbell.bsky.social a DM if you'd like to meet up to learn more!

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Exciting Instruments @ei-science.bsky.social · 12/01/2026

Biology happens when molecules interact - in solution, in motion, in fleeting moments. Freely diffusing smFRET captures these dynamics with nanometre precision. Our new practical #smFRET handbook distils principles & analysis for confident, in-solution data. 📘 buff.ly/AgGQCLY #singlemolecule

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Exciting Instruments @ei-science.bsky.social · 07/01/2026

🇺🇸 We're in beautiful #SanFrancisco next week (Mon-Thurs) to meet with investors and customers. If you're in the area, we’d love to connect to discuss the power of in-solution #single-molecule techniques and our Exciting plans for 2026. Email info@excitinginstruments.com to let us know.

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Exciting Instruments @ei-science.bsky.social · 17/12/2025

🔎 Cryo-EM reveals stunning structures and partners perfectly with dynamic single-molecule methods to link structure to motion, uncover rare states, validate flexible regions, and map conformational changes. Get in touch to learn more - buff.ly/ncBOTrM #biochemistry #structuralbiology

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Exciting Instruments @ei-science.bsky.social · 15/12/2025

🙌 What - an - Exciting - year! Thank you to everyone who has supported us throughout 2025 - it has enabled us to dream big, turn those dreams into action, bring our mission to life, and ultimately achieve all of the Exciting progress we've made. 🥂🎄🌟 Have a wonderful festive break. Here's to 2026!

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Exciting Instruments @ei-science.bsky.social · 08/12/2025

smFRET tracks one molecule at a time to reveal real low/high-FRET populations, dynamic transitions, and nanoscale changes that traditional FRET masks. Learn more - bit.ly/44TVTwy #smFRET #biophysics #singlemolecule

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Exciting Instruments @ei-science.bsky.social · 03/12/2025

⏰ What if your experimental workflow went from weeks to minutes? @shenk0128.bsky.social shares how solution-based measurements complement TIRF: ✓ Faster results ✓ Fewer artefacts ✓ No tethering needed ✓ Proteins stay in their native, comfortable state #singlemolecule #TIRF #proteinstructure

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Exciting Instruments @ei-science.bsky.social · 20/11/2025

Two hours to go! Join @shenk0128.bsky.social and @timcraggs.bsky.social as they dive into Rag GTPase regulation, #proteindynamics, and cutting-edge #singlemolecule science. Can’t make it live? Register to get the recording - us06web.zoom.us/meeting/regi... #biophysics #lifescience #biophysics

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Exciting Instruments @ei-science.bsky.social · 18/11/2025

🚨 Happening this Thursday! @timcraggs.bsky.social and @shenk0128.bsky.social discussing: → cutting-edge single-molecule science → insights into the mechanism and regulation of the Rag GTPase heterodimer Register here: buff.ly/GcdLpHI #seminar #proteins #singlemolecule #biophysics #biochemistry

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Exciting Instruments @ei-science.bsky.social · 12/11/2025

⚡ What do you get when you combine a meaningful mission, innovative solutions, and an epic group of people? Something extremely Exciting 😉 We're looking for brilliant people to fill these roles & more > excitinginstruments.com/careers/ #lifesciencejobs #startupjobs #sheffieldjobs #hiring #scaleup

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