Dedicate my first post to a new publication! Our student Dylan Doxsey established a single molecule FRET system to visualize the global conformation of the Rag GTPases. Turns out the overall shape is as important as the local conformation.
www.pnas.org/doi/10.1073/...
pnas.org
Global conformation of the Rag GTPase heterodimer governs eukaryotic amino acid sensing | PNAS
The Rag GTPase heterodimer is a central mediator of amino acid sensing in eukaryotic
cells. When amino acids are abundant, it binds to the mechanis...