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Ellen Hanna Singleton, PhD

@ehsingleton.bsky.social
106 followers 49 following 1 posts

Post-doc @goteborgsuni | former post-doc @LundUniversity | former PhD student @AlzheimerAms | cognition, imaging and fluid biomarkers in #AD | 🏴󠁧󠁢󠁥󠁮󠁧󠁿🇳🇱🇸🇪

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Reposted by Ellen Hanna Singleton, PhD
REAL AD @real-ad.bsky.social · 31/03/2025
The REAL AD team has arrived in Vienna for #ADPD2025 ! 🇦🇹🧠 ✨ We are excited to share our latest work and connect with fellow colleagues at the conference. Come find us at our team talks and poster sessions - @michaelschoell.bsky.social, @ehsingleton.bsky.social #EndAlz #Alzheimersresearch
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Reposted by Ellen Hanna Singleton, PhD
Suzanne E. Schindler @suzanneeschindler.bsky.social · 31/03/2025
We now have a blood biomarker that is even more strongly associated with tau PET and cognitive symptoms than even p-tau217! Plasma eMTBR-tau243 will help us to understand whether cognitive impairment is likely to be related to Alzheimer's pathology. #ENDALZ www.nature.com/articles/s41...
nature.com
Plasma MTBR-tau243 biomarker identifies tau tangle pathology in Alzheimer’s disease - Nature Medicine
Plasma eMTBR-tau243 is a specific biomarker of tau tangles in Alzheimer’s disease and enables the detecting and tracking of Alzheimer’s clinical impairment.
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Reposted by Ellen Hanna Singleton, PhD
Shane Liddelow @liddelowsa.bsky.social · 10/12/2024
it's big, and it's a review of 601 papers on the topic - but here's an update on Neuroinflammation in Alzheimer's Disease www.nature.com/articles/s41... led by Michael Heneka, published in @natrevimmunol.bsky.social today (MANY more authors listed and linked below)
nature.com
Neuroinflammation in Alzheimer disease - Nature Reviews Immunology
This Review provides an in-depth examination of how inflammation contributes to neurodegeneration in Alzheimer disease. The authors explore the impact of extrinsic factors, such as brain trauma, diet ...
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Reposted by Ellen Hanna Singleton, PhD
Eduardo Zimmer @erzimmer.bsky.social · 25/11/2024
@zimmerneurolab.bsky.social debut here in 🦋 with an autoradiographic head-to-head study comparing tau PET tracers in the postmortem brain tissue 👇
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Ellen Hanna Singleton, PhD @ehsingleton.bsky.social · 26/11/2024
Congrats Eduardo et al!! 👏
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Reposted by Ellen Hanna Singleton, PhD
Nico Franzmeier @nfranzme.bsky.social · 25/11/2024
Massive paper alert: We performed extensive profiling of PI-2620 for 4R tauopathies. PI-2620 tau PET signals in PSP stem from neuronal and oligodendroglial tau, not astrocytes. Signals correlate with fibrillary tau, autoradiography, and autopsy data in PSP doi.org/10.1007/s004...
doi.org
Neuronal and oligodendroglial, but not astroglial, tau translates to in vivo tau PET signals in individuals with primary tauopathies - Acta Neuropathologica
Tau PET has attracted increasing interest as an imaging biomarker for 4-repeat (4R)-tauopathy progressive supranuclear palsy (PSP). However, the translation of in vitro 4R-tau binding to in vivo tau P...
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